Éditeur(s) : Amer Geophysical Union
Résumé : Seismic noise is an indirect source of information on ocean waves. Using a model of noise generation and propagation, seismic stations can be separated into those that are mostly sensitive to local sea states, and those that integrate sources from a large oceanic area. The model also provides a classification of noise-generating sea states into three classes. The analysis of Central California seismic noise data, well correlated with local waves, reveals that class I events dominate in summer, caused by a single wind-sea system, and for which ocean wave spectral levels are proportional to seismic spectral levels to an exponent b similar or equal to 0.9. In winter, noise is dominated by class II generation, for which coastal reflection is important, with a wave spectral density roughly proportional to the seismic spectral density to an exponent b similar or equal to 0.7. Sporadic events of class III probably produce some of the strongest noise events in Central California and need to be properly screened. These events are caused by opposed wave systems that are usually the wind-sea and a swell. This noise classification can be used to improve on the correlation between measured and estimated wave heights(up to r = 0.93 for daily averages). For other locations, where remote oceanic sources are recorded, a significant wave height estimated from the seismic noise compares well with area-averaged satellite data or wave model results(r > 0.85 for daily averages). These analyses pave the way for quantitative uses of seismic records, including the reconstruction of past wave climates, and the calibration of wave hindcasts.
Journal Of Geophysical Research-oceans (0148-0227) (Amer Geophysical Union), 2012-05 , Vol. 117 , N. C05002 , P. 19 pp.

Droits : 2012 AGU
http://archimer.ifremer.fr/doc/00083/19443/17051.pdf
DOI:10.1029/2011JC007449
http://archimer.ifremer.fr/doc/00083/19443/

Éditeur(s) : Oxford Univ Press
Résumé : Biological reference points are important tools for fisheries management. Reference points are not static, butmay change when a population's environment or the population itself changes. Fisheries-induced evolution is one mechanism that can alter population characteristics, leading to "shifting" reference points by modifying the underlying biological processes or by changing the perception of a fishery system. The former causes changes in "true" reference points, whereas the latter is caused by changes in the yardsticks used to quantify a system's status. Unaccounted shifts of either kind imply that reference points gradually lose their intended meaning. This can lead to increased precaution, which is safe, but potentially costly. Shifts can also occur in more perilous directions, such that actual risks are greater than anticipated. Our qualitative analysis suggests that all commonly used reference points are susceptible to shifting through fisheries-induced evolution, including the limit and "precautionary" reference points for spawning-stock biomass, B-lim and B-pa, and the target reference point for fishing mortality, F-0.1. Our findings call for increased awareness of fisheries-induced changes and highlight the value of always basing reference points on adequately updated information, to capture all changes in the biological processes that drive fish population dynamics.
Ices Journal Of Marine Science (1054-3139) (Oxford Univ Press), 2013-07 , Vol. 70 , N. 4 , P. 707-721

Droits : 2013 International Council for the Exploration of the Sea. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com
http://archimer.ifremer.fr/doc/00151/26228/24302.pdf
DOI:10.1093/icesjms/fst077
http://archimer.ifremer.fr/doc/00151/26228/

Éditeur(s) : HAL CCSD National Institute of Environmental Health Sciences
Résumé : International audience
Safe drinking water is essential for well-being. Although microbiological contamination remains the largest cause of water-related morbidity and mortality globally, chemicals in water supplies may also cause disease, and evidence of the human health consequences is limited or lacking for many of them. We aimed to summarize the state of knowledge, identify gaps in understanding, and provide recommendations for epidemiological research relating to chemicals occurring in drinking water. Assessing exposure and the health consequences of chemicals in drinking water is challenging. Exposures are typically at low concentrations, measurements in water are frequently insufficient, chemicals are present in mixtures, exposure periods are usually long, multiple exposure routes may be involved, and valid biomarkers reflecting the relevant exposure period are scarce. In addition, the magnitude of the relative risks tends to be small. Research should include well-designed epidemiological studies covering regions with contrasting contaminant levels and sufficient sample size; comprehensive evaluation of contaminant occurrence in combination with bioassays integrating the effect of complex mixtures; sufficient numbers of measurements in water to evaluate geographical and temporal variability; detailed information on personal habits resulting in exposure (e.g., ingestion, showering, swimming, diet); collection of biological samples to measure relevant biomarkers; and advanced statistical models to estimate exposure and relative risks, considering methods to address measurement error. Last, the incorporation of molecular markers of early biological effects and genetic susceptibility is essential to understand the mechanisms of action. There is a particular knowledge gap and need to evaluate human exposure and the risks of a wide range of emerging contaminants.
ISSN: 0091-6765

hal-01118530
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118530
PUBMED : 24380896
DOI : 10.1289/ehp.1206229
PUBMEDCENTRAL : PMC3948022

Éditeur(s) : INRA
Résumé : According to the world organisation for animal health (OIE) an emerging disease is defined as a recently admitted serious illness, whose aetiology can, or not, have already been established, and which is likely to be propagated within a population or between populations, for example at the time of international exchanges of aquatic animals and/or products of aquatic animals. Even though the emerging diseases that affect human health have been much studied, those which affect marine organisms and species of aquaculture interest in particular are poorly documented. By restricting emergence to only infectious diseases, we aim at presenting in a non-exhaustive way some scenarios of the emergence of the diseases of aquacultured species by illustrating them with three examples available in the scientific literature: one relating to the appearance of a pathogenic agent in a new host with the case of the herpesvirus of the Koï carp, the other with the evolution of a pre-existing pathogenic agent with the case of shrimp vibriosis due to Vibrio nigripulchritudo in New Caledonia, and the last example relating to the introduction of one pathogenic pre-existing pathogen in an unscathed area with the case of Bonamia ostreae infecting the flat oyster Ostrea edulis. The causes of the emergence of diseases are multiple and implicate in an intercurrent way pathogenic agents, the environment, the host or host species and anthropogenic factors. In the marine environment, these causes are very often ignored. In this context, the development of zoosanitary surveillance networks and diagnostic tools present a considerable interest in order to anticipate, prevent and/or intervene on the emergence of the diseases by limiting their sanitary, ecological and political consequences.
Selon l'Office International des Epizooties (OIE) une maladie émergente désigne une maladie grave récemment reconnue, dont la cause peut, ou non, avoir déjà été établie, et qui est susceptible de se propager au sein d'une population ou entre des populations, par exemple à l'occasion d'échanges internationaux d'animaux aquatiques et/ou de produits d'animaux aquatiques. Si les maladies émergentes qui affectent la santé humaine ont été très étudiées, celles qui touchent les organismes marins et les organismes aquacoles d'intérêt économique en particulier sont en revanche peu documentées. C'est en restreignant l'émergence aux seules maladies infectieuses que seront présentés de façon non exhaustive quelques scénarios de l'émergence des maladies chez les organismes d'intérêt aquacole en les illustrant par trois exemples disponibles dans la littérature scientifique : l'un relatif à l'apparition d'un agent pathogène chez un nouvel hôte avec le cas de l'herpesvirus de la carpe Koï, l'autre à l'évolution d'un agent pathogène existant avec le cas de la vibriose à Vibrio nigripulchritudo sévissant dans les élevages de crevettes pénéides de Nouvelle-Calédonie et enfin le dernier lié à l'introduction d'un pathogène préexistant avec le cas de Bonamia ostreae infectant l'huître plate Ostrea edulis. Les causes d'émergence de maladies sont multiples et font intervenir de façon intercurrente l'agent pathogène, l'environnement, l'hôte ou les espèces hôtes et des facteurs anthropiques. Dans le milieu marin, ces causes sont bien souvent méconnues. Dans ce contexte le développement des réseaux de surveillance et des techniques de diagnostic revêtent un intérêt considérable afin d'anticiper, de prévenir et/ou d'intervenir sur l'émergence des maladies en limitant leur conséquences sanitaires, écologiques et politiques.
INRA Productions Animales (INRA), 2007-07 , Vol. 20 , N. 3 , P. 207-212

Droits : INRA
http://archimer.ifremer.fr/doc/2007/publication-2980.pdf
http://archimer.ifremer.fr/doc/00000/2980/

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
BACKGROUND: Histoplasmosis is an endemic fungal infection in French Guiana. It is the most common AIDS-defining illness and the leading cause of AIDS-related deaths. Diagnosis is difficult, but in the past 2 decades, it has improved in this French overseas territory which offers an interesting model of Amazonian pathogen ecology. The objectives of the present study were to describe the temporal trends of incidence and mortality indicators for HIV-associated histoplasmosis in French Guiana. METHODS: A retrospective study was conducted to describe early mortality rates observed in persons diagnosed with incident cases of HIV-associated Histoplasma capsulatum var. capsulatum histoplasmosis admitted in one of the three main hospitals in French Guiana between 1992 and 2011. Early mortality was defined by death occurring within 30 days after antifungal treatment initiation. Data were collected on standardized case report forms and analysed using standard statistical methods. RESULTS: There were 124 deaths (45.3%) and 46 early deaths (16.8%) among 274 patients. Three time periods of particular interest were identified: 1992-1997, 1998-2004 and 2005-2011. The two main temporal trends were: the proportion of early deaths among annual incident histoplasmosis cases significantly declined four fold (χ2, p<0.0001) and the number of annual incident histoplasmosis cases increased three fold between 1992-1997 and 1998-2004, and subsequently stabilized. CONCLUSION: From an occasional exotic diagnosis, AIDS-related histoplasmosis became the top AIDS-defining event in French Guiana. This was accompanied by a spectacular decrease of early mortality related to histoplasmosis, consistent with North American reference center mortality rates. The present example testifies that rapid progress could be at reach if awareness increases and leads to clinical and laboratory capacity building in order to diagnose and treat this curable disease.
ISSN: 1935-2727

inserm-01065109
http://www.hal.inserm.fr/inserm-01065109
http://www.hal.inserm.fr/inserm-01065109/document
http://www.hal.inserm.fr/inserm-01065109/file/PLOS_Neglected_Tropical_Dis_2014.pdf
http://www.hal.inserm.fr/inserm-01065109/file/2014_Adenis_-_HIV-associated_histoplasmosis_early_mor.pdf

Éditeur(s) : HAL CCSD Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists
Résumé : International audience
Hepatic periportal fibrosis, which affects 5–10% of subjects infected by Schistosoma mansoni, is caused by the T cell-dependent granuloma that develop around schistosome eggs. Experimental models of infection have shown that granuloma and fibrosis are tightly regulated by cytokines. However, it is unknown why advanced periportal fibrosis occurs only in certain subjects. The goal of the present study was to evaluate the cytokine response of S. mansoni-infected subjects with advanced liver disease in an attempt to relate susceptibility to periportal fibrosis with an abnormal production of cytokines that regulate granuloma and fibrosis. Fibrosis was evaluated by ultrasound on 795 inhabitants of a Sudanese village in which S. mansoni is endemic: advanced periportal fibrosis was observed in 12% of the population; 35% of the affected subjects exhibited signs of portal hypertension. Age (odds ratio (OR), 11.5), gender (OR, 4.2), and infection levels (OR, 2.2) were significantly (p < 0.01) associated with hepatic fibrosis. Cytokines produced by egg-stimulated blood mononuclear cells from 99 subjects were measured (75 with no or mild fibrosis; 24 subjects with advanced fibrosis). Multivariate analysis of cytokine levels showed that high IFN-γ levels were associated with a marked reduction of the risk of fibrosis (p = ‫OR, 0.1); in contrast, high TNF-α levels were associated with an increased risk (p = 0.05; OR, 4.6) of periportal fibrosis. Moreover, infection levels were negatively associated with IFN-γ production. These results with observations in experimental models strongly suggest that IFN-γ plays a key role in the protection of S. mansoni-infected patients against periportal fibrosis, whereas TNF-α may aggravate the disease.
ISSN: 0022-1767

Droits : http://creativecommons.org/licenses/by-nc-nd/
hal-01211587
https://hal.archives-ouvertes.fr/hal-01211587
https://hal.archives-ouvertes.fr/hal-01211587/document
https://hal.archives-ouvertes.fr/hal-01211587/file/929.full.pdf
DOI : 10.4049/jimmunol.169.2.929

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
BACKGROUND: Mammalian spermatogenesis is a process that involves a complex expression program in both somatic and germ cells present in the male gonad. A number of studies have attempted to define the transcriptome of male meiosis and gametogenesis in rodents and primates. Few human transcripts, however, have been associated with testicular somatic cells and germ cells at different post-natal developmental stages and little is known about their level of germline-specificity compared with non-testicular tissues. METHODS: We quantified human transcripts using GeneChips and a total of 47 biopsies from prepubertal children diagnosed with undescended testis, infertile adult patients whose spermatogenesis is arrested at consecutive stages and fertile control individuals. These results were integrated with data from enriched normal germ cells, non-testicular expression data, phenotype information, predicted regulatory DNA-binding motifs and interactome data. RESULTS: Among 3580 genes for which we found differential transcript concentrations in somatic and germ cells present in human testis, 933 were undetectable in 45 embryonic and adult non-testicular tissues, including many that were corroborated at protein level by published gene annotation data and histological high-throughput protein immunodetection assays. Using motif enrichment analyses, we identified regulatory promoter elements likely involved in germline development. Finally, we constructed a regulatory disease network for human fertility by integrating expression signals, interactome information, phenotypes and functional annotation data. CONCLUSIONS: Our results provide broad insight into the post-natal human testicular transcriptome at the level of cell populations and in a global somatic tissular context. Furthermore, they yield clues for genetic causes of male infertility and will facilitate the identification of novel cancer/testis genes as targets for cancer immunotherapies.
ISSN: 0268-1161

hal-00877243
https://hal.archives-ouvertes.fr/hal-00877243
DOI : 10.1093/humrep/des301
PUBMED : 22926843

Éditeur(s) : Aquaculture 67 : 260-261
Résumé : An infection caused by a Perkinsus -like parasite has been observed in Ruditapes decussatus from Portugal (Comps and Chagot, 1987). Following a pathological study carried out on clams affected by mortalities in the Algarve area, this parasite was found again, inducing a reaction process in the host. Histological examination reveals the parasite in the connective tissue of different organs. The adjoining tissues, particularly the epithelia, are not affected.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/1987/acte-3109.pdf
http://archimer.ifremer.fr/doc/00000/3109/

Éditeur(s) : HAL CCSD American Society of Tropical Medicine and Hygiene
Résumé : International audience
Histoplasmosis is the first cause of acquired immunodeficiency syndrome (AIDS) and AIDS-related deaths in French Guiana. Cohort data were used to determine whether primary prophylaxis with 100 mg itraconazole for patients with CD4 counts < 150/mm(3) was cost-effective with different scenarios. For a scenario where 12% of patients died, 60% were aware of their human immunodeficiency virus (HIV) infection and adherence was only 50%, primary prophylaxis would prevent 1 death and 9 cases of histoplasmosis for a cost of 36,792 Euros per averted death, 1,533 per life-year saved, 4,415 Euros per averted case, when only counting the costs of itraconazole prophylaxis. Taking into account the total costs of hospitalization showed that primary prophylaxis would allow a savings of 185,178 Euros per year. Even in a scenario of low adherence, primary prophylaxis would be cost-effective in French Guiana, and presumably in the rest of the Guianas and the Amazon.
ISSN: 0002-9637

inserm-00913886
http://www.hal.inserm.fr/inserm-00913886
http://www.hal.inserm.fr/inserm-00913886/document
http://www.hal.inserm.fr/inserm-00913886/file/2013_Nacher_-_Primary_prophylaxissur disseminated_histoplasmosis_in_HIV_patients_in_French_Guiana_a_cost_effectiveness_study.pdf
DOI : 10.4269/ajtmh.13-0082

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
Exposure to disturbance is rarely considered in marine protected area planning. Typically, representing and replicating the habitat types present within protected areas is used to spread the risk of protecting frequently disturbed sites. This was the approach used during the 2004 re-zoning of the Great Barrier Reef Marine Park (GBRMP) via the Representative Areas Program. Over 10 years later, we examine whether the risk was spread by mapping exposure of coral reefs in the GBRMP to four disturbances that cause coral mortality: bleaching, tropical cyclones, crown-of-thorns starfish outbreaks, and freshwater inundation. Our objectives were to: (1) assess whether no-take areas include a range of disturbance regimes, and (2) identify coral reef areas with lower relative exposure. At least 13% and an average of 31% of reef locations in each of 11 exposure classes are included within no-take areas. A greater proportion of low-exposure areas are within no-take areas than high-exposure areas (34.2% vs. 28.3%). The results demonstrate the value of risk spreading when exposure data are not available while also showing that regularly assessing exposure increases capacity for adaptive, resilience-based reef management.
ISSN: 1755-263X

Droits : http://creativecommons.org/licenses/by/
hal-01225201
https://hal-univ-perp.archives-ouvertes.fr/hal-01225201
https://hal-univ-perp.archives-ouvertes.fr/hal-01225201/document
https://hal-univ-perp.archives-ouvertes.fr/hal-01225201/file/Maynard_et_al-2015-Conservation_Letters.pdf
DOI : 10.1111/conl.12198

Éditeur(s) : HAL CCSD American Geophysical Union (AGU)
Résumé : International audience
Sandbox modeling is used to study the deformation of accretionary wedges caused by the subduction of oceanic ridges. The first experiment incorporates a massive ridge within a sand wedge. The wedge thickens and shortens when the forward propagation of the basal decollement ceases. The wedge thickening results in taper change, reactivation of preexisting thrusts, and retreat of the frontal part of the sand wedge. Similar mechanisms may have affected some margins that have undergone ridge subduction such as the Tonga margin after the subduction of the oblique Louisville oceanic ridge. The second experiment shows the effects of an active basement thrust slice as it enters a subduction zone. This process may have happened in the eastern Nankai accretionary wedge. Initially, the wedge in this experiment behaved similarly to that of the first experiment. Rapidly the topographic slope changed, the wedge thickened above the basement slice generating a slope break in the topography; a deeper propagating accretionary wedge again characterized by a small taper developed. These results, when compared with observations made in the Eastern Nankai Trench, are in agreement with the past subduction of a basement thrust slice in this area.
ISSN: 0278-7407

hal-01261549
https://hal.archives-ouvertes.fr/hal-01261549
https://hal.archives-ouvertes.fr/hal-01261549/document
https://hal.archives-ouvertes.fr/hal-01261549/file/Lallemand_et_al-1992-Tectonics.pdf
DOI : 10.1029/92TC00637

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
INTRODUCTION: Light chain deposition disease is a rare clinical entity characterized by deposition of monoclonal immunoglobulin light chains in organs. The kidneys are almost always affected, while the lung manifestations that have been reported, including nodular or diffuse disease, especially cystic lesions, are unusual. CASE REPORT: We report the case of a 60-year-old man with a diffuse infiltrative lung disease characterized by numerous apical cysts. The diagnosis of light chain deposition cystic lung disease was obtained by surgical lung biopsy. Light chain deposits in the salivary glands were the only extrapulmonary manifestation. Despite 12 chemotherapy cycles, the patient's lung function and radiological appearances worsened. CONCLUSION: This is the fourth case describing a cystic lung disease due to light chain deposition in the literature. It highlights the need for comprehensive investigations so as not to miss this rare cause of cystic lung disease, which appears to be related to a primary pulmonary lymphoproliferative disorder. The only treatment that appears to be effective is lung transplantation.
ISSN: 0761-8425

hal-00873356
https://hal.archives-ouvertes.fr/hal-00873356
https://hal.archives-ouvertes.fr/hal-00873356/document
https://hal.archives-ouvertes.fr/hal-00873356/file/DA_pots_chaines_lA_gA_res_non_amyloides_version_finale.pdf
DOI : 10.1016/j.rmr.2013.02.003

Résumé : Depuis les débuts de la pêche à la crevette en Guyane par les flottilles des Etats-Unis et du Japon (1968), le laboratoire halieutique de l’Ifremer a suivi cette exploitation. La production débarquée, ainsi que l’échantillonnage des captures ont été mis en place pour répondre aux besoins de gestion. L’évolution des débarquements de cette pêcherie a connu une première diminution significative en 1999, puis en 2006. Cette situation conduit à étudier plus précisément les causes de cette chute dans les débarquements, qui semble être d’ordre climatique (Lampert 2011a).

Droits : 2011 Ifremer
http://archimer.ifremer.fr/doc/00075/18615/16168.pdf
http://archimer.ifremer.fr/doc/00075/18615/

Éditeur(s) : HAL CCSD Blackwell Publishing
Résumé : International audience
In the Causses platform (south-east France), Late Hettangian to Sinemurian deposits were interpreted previously as shallow-water carbonate ramp deposits. A new look at these deposits has shown a fault-controlled mosaic carbonate platform that is different from the carbonate ramp models. Within the platform mosaic, 15 lithofacies have been recognized, which are organized in four facies associations, including peritidal, restricted shallow sub-tidal, sand dunes and sub-tidal shelf facies associations. The rapid lateral and vertical facies changes, and the lack of consistent landward or seaward direction indicated by the pattern of facies changes, question the existence of a shoreline suggested by the traditional models for this region. Instead, the facies organization and cycle stacking pattern suggest deposition in a mosaic of intertidal islands between which sub-tidal restricted or open conditions could coexist in very close proximity. Such a platform mosaic would have been defined by tectonic activities along normal faults which segmented the shallow-water Causses platform. The facies and facies associations are arranged into metre-scale, peritidal and sub-tidal cycles that are also variable. Certain cycles show the same stacking pattern in all the sections and seem to be traceable over tens of kilometres. On the contrary, other cycles cannot be correlated; they are present only in specific sections and have a maximum lateral extension of 1 or 2 km. These metre-scale cycles stack to form four medium-scale cycles bounded by surfaces that display sub-aerial exposure features. Medium-scale cycles stack into two larger-scale cycles (tens of metres thick) and are bounded by well-defined karstic surfaces. Based on their lateral continuity and their stacking pattern, the metre-scale cycles are controlled probably by high frequency eustatic variations overprinting the topographic irregularities formed by differential subsidence of fault-bounded blocks. Episodic fault activities may reorganize the topography so that, even if eustatic changes may still be the major control of cycles, the expression and number of cycles could be different. Cycles of medium and large-scale are interpreted as being allogenic, controlled by changes in eustasy and/or subsidence rates as evidenced by their lateral continuity and the correlations of the large-scale cycles with third-order depositional sequences.
ISSN: 1469-3496

hal-00411940
https://hal.archives-ouvertes.fr/hal-00411940
DOI : 10.1111/j.1365-3091.2007.00896.x

Éditeur(s) : HAL CCSD
Résumé : L’agriculture aux Antilles, depuis la période coloniale, est orientée vers quelques monocultures, de la canne à sucre à la banane en passant par le coton et le café (Lasserre, 1961). Aux côtés de cette agriculture exportatrice, les agrosystèmes multi-espèces sont aussi très anciens mais ont longtemps fonctionné de façon isolée et sur une base empirique notamment à travers les jardins familiaux ou "jardin créole" (Degras, 2005). De plus en plus, l'intérêt, voire la nécessité d'une diversification professionnelle de l'activité agricole aux Antilles est admise, reconnue voire soutenue compte tenu des impasses agronomiques, environnementales ou économiques L’insularité d’un territoire entraine de nombreux conflits d’usage dans la gestion du capital foncier. La nécessité de terres à bâtir dans un contexte d’augmentation de la population, la nécessité de protection de la forêt tropicale, des forêts marécageuses de mangroves et des zones à proximité des rivières amènent de nombreuses questions en matière d’aménagement et de gestion des territoires surtout lorsqu’ils sont exigus. L’agriculture est un secteur consommateur d’espace et ce pour l’ensemble des productions agricoles Aux Antilles, l’agriculture connaît de lourds héritages avec la prépondérance des cultures destinées à l’exportation et gourmandes en surfaces, la canne à sucre et la banane. La gestion des territoires mais aussi des pratiques agricoles sont très clairement remises en cause depuis la crise médiatique de la chlordécone en 2002 et les années suivantes par les successives interdictions prononcées par arrêtés préfectoraux depuis la crise sociale de 2009 décriant les cultures d’exportation pour leur caractère polluant et intensif et appelant à un retour aux productions locales plus respectueuses de l’environnement. Les systèmes productifs sont sans cesse en évolution. Ces changements sont le reflet des choix productifs effectués par les exploitants et par des pratiques agricoles mises en œuvre. L’analyse du système se fera de manière à identifier les spéculations initiales et leurs évolutions au cours de la dernière décennie. La diffusion spatiale de ces pratiques agricoles ne s’effectue pas linéairement car, dans les systèmes productifs, le phénomène est bien plus complexe dont la compréhension nécessite la prise en compte (i) des interactions entre les acteurs et (ii) de l’aspect temporel. L’émission d’un message informatif évolue dans le temps ainsi que les acteurs et leurs interactions sur le territoire. Même si les agriculteurs sont soumis à des facteurs exogènes communs à l’ensemble de leur exploitation, ils sont tout de même concernés par des influences provenant des réseaux au sein desquels ils sont insérés. Le processus classique de diffusion des pratiques agricoles est résumé par la courbe logistique (Hägerstrand, 1967). Sur le territoire, la situation d’adoption de pratiques n’est pas homogène. Pour une compréhension et une anticipation quant à l’évolution du territoire, l’ensemble des DOM antillais sera sujet à étude. Dans un premier temps, l’analyse des spéculations des systèmes multi-espèces à travers une analyse exploratoire des données permettra de mieux appréhender les dynamiques spatiales perceptibles sur le territoire et ce en fonction du type de production agricole. Pour modéliser la dynamique spatiale de diffusion des choix, il faudra envisager une combinaison de plusieurs approches géographiques pour une meilleure compréhension de la situation et ce en fonction de la complexité du système multi-espèces proposé au sein d’une même exploitation. Il s’agit par la géographie historique de s’intéresser aux changements survenus dans les modèles agricoles au cours du temps en d’étudier l'utilisation des terres agricoles au cours de la dernière décennie (approche diachronique) et la photographie du paysage agricole aux Antilles Françaises (approche synchronique). Ces deux approches synchroniques et diachroniques, révèlent respectivement les corrélations entre plusieurs éléments qui se trouvent dans un même lieu à une période donnée et met l'accent sur les processus de l'activité agricole qui sous-tendent les changements dans les modèles géographiques. La diffusion d’une pratique peut être analysée tout d’abord temporellement (Rogers, 1983) en estimant qu’il n’existe pas de différenciation spatiale dans le phénomène. Dans un deuxième temps, la considération de la dimension spatiale (Hägerstrand, 1967) dans l’étude de la diffusion devient primordiale pour l’étude de diffusion d’une pratique agricole dans des territoires diversifiés même s’ils sont insulaires et exigus. Les processus de diffusion spatiale sont perceptibles à différentes échelles spatiales (Aber, 1972) et il s’agit de déterminer les échelles d’études les plus pertinentes pour clarifier le phénomène : de l’échelle régionale à l’échelle locale (Morrill, 1970). La difficulté est de sélectionner la meilleure échelle pour établir un modèle de diffusion spatio-temporelle (Morrill, 1970). Il s’agira, dans la présente étude, d’opter pour une analyse en « time-geography » (Chardonnel, 2001) à savoir une analyse des réactions des individus dans le temps et l’espace : le comportement des agriculteurs face à leur pratique de 2000 à aujourd’hui et la diffusion spatio-temporelle de ces pratiques agricoles sur le territoire. L’objectif principal de la thèse est de comprendre et de modéliser les processus de diffusion spatiale des pratiques agricoles dans les systèmes productifs multi-espèces aux Antilles françaises. Il s’agira de retracer l’apparition des pratiques agricoles de la dernière décennie des agriculteurs n’ayant pas de mono-spéculation mais développant des systèmes productifs multi-espèces et touchant par conséquent différents secteurs agricoles (banane, canne, élevage, maraîchage…) et tout cela dans une même exploitation agricole. L’enjeu sera d'identifier les différents évènements significatifs survenus et subis par les différentes filières agricoles concernées et les producteurs, évènements marquants intervenus au cours de la période, tant climatiques, parasitaires, qu'organisationnels, structurels, réglementaires, marchands ou sociaux. Chaque agriculteur souhaite faire converger son système de production vers ses objectifs productifs en tenant compte des évolutions contextuelles d’exercice de son activité et ce, en fonction de l’offre technologique disponible dans la période correspondante. Il s’agira d’établir un modèle spatio-temporel de diffusion d’pratiques agricoles en tenant compte des facteurs moteurs et facteurs barrières à l’adoption et en donnant des poids différents aux différents facteurs d’influence. L’adoption de pratiques agricoles dépend de la situation géographique de l’exploitation, de la distance par rapport à l’innovateur : le principal déterminant spatial de l’adoption dans les filières de diversification, moins sujettes à un message technique unilatéral prodigué pour des filières très structurées, est l’effet de « mimétisme » (Girard, 1961). Cette adoption dépend également de l’interconnexion entre les différents acteurs de filière. Ce lien n’est peut-être pas nécessairement lié à la proximité géographique des individus mais à une proximité sociale résultant de l’appartenance à un ou plusieurs réseaux sociaux (Granovetter, 1983). L’accessibilité à l’information et la réaction de l’agriculteur face aux changements de pratiques dépend de son appartenance à un groupe social. Dans des filières très bien structurées (canne à sucre et banane), le message technique diffusé est homogène à toute la population et est influencé grandement par des facteurs exogènes à l’exploitant. La dimension spatiale et les réseaux sociaux sont des facteurs influençant les choix des exploitants et ce selon le type d’exploitations (monoculture ou multi-espèces). Actuellement, il semblerait que ce soit le type d’exploitation (taille et localisation) qui influence le choix de l’exploitation dans l’adoption d’innovation en milieu bananier (Mantran, 2011). A partir des techniques d’exploration des données, on pourra aboutir à la mise au point d’un modèle explicatif de la diffusion d’informations et ce probablement par type de production. Cette étude permettra une meilleure connaissance du territoire et de ses dynamiques spatiales agricoles.
Doctoriales du CEREGMIA
Cayenne, Guyane, France

hal-01458425
https://hal.archives-ouvertes.fr/hal-01458425
PRODINRA : 384817

Éditeur(s) : Public Library Science
Résumé : Biological invasions rank amongst the most deleterious components of global change inducing alterations from genes to ecosystems. The genetic characteristics of introduced pools of individuals greatly influence the capacity of introduced species to establish and expand. The recently demonstrated heritability of microbial communities associated to individual genotypes of primary producers makes them a potentially essential element of the evolution and adaptability of their hosts. Here, we characterized the bacterial communities associated to native and non-native populations of the marine green macroalga Caulerpa racemosa through pyrosequencing, and explored their potential role on the strikingly invasive trajectory of their host in the Mediterranean. The similarity of endophytic bacterial communities from the native Australian range and several Mediterranean locations confirmed the origin of invasion and revealed distinct communities associated to a second Mediterranean variety of C. racemosa long reported in the Mediterranean. Comparative analysis of these two groups demonstrated the stability of the composition of bacterial communities through the successive steps of introduction and invasion and suggested the vertical transmission of some major bacterial OTUs. Indirect inferences on the taxonomic identity and associated metabolism of bacterial lineages showed a striking consistency with sediment upheaval conditions associated to the expansion of their invasive host and to the decline of native species. These results demonstrate that bacterial communities can be an effective tracer of the origin of invasion and support their potential role in their eukaryotic host's adaptation to new environments. They put forward the critical need to consider the 'meta-organism' encompassing both the host and associated micro-organisms, to unravel the origins, causes and mechanisms underlying biological invasions.
Plos One (1932-6203) (Public Library Science), 2013-07 , Vol. 8 , N. 7 , P. -

Droits : 2013 Aires et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
http://archimer.ifremer.fr/doc/00157/26791/24886.pdf
DOI:10.1371/journal.pone.0068429
http://archimer.ifremer.fr/doc/00157/26791/

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : National audience
Introduction Les télomérases sont les enzymes assurant la synthèse des télomères, séquences d’ADN essentiels dans la protection des chromosomes. Les mutations des télomérases sont responsables, entre autres, d’anomalies hématologiques, pulmonaires (fibrose pulmonaire idiopathique) et hépatiques. Il n’y a que peu de données dans la littérature concernant les résultats des transplantations pulmonaires chez ces patients mutés. Cas clinique Nous rapportons le cas d’un jeune homme de 39 ans, souffrant de syndrome myélodysplasique associé à une fibrose pulmonaire, permettant de poser le diagnostic de téloméropathie (mutation de la sous-unité ARN ou TERC ; r.182delG, pseudoknot area). L’insuffisance médullaire est sévère : leucopénie à 1,3 G/L dont 0,54 G/L de PNN, anémie macrocytaire (Hb à 10,3 g/dL ; VGM à 120 fL) et thombopénie à 27 G/L. Le syndrome restrictif est également sévère avec une CPT à 60 % et une CVF à 82 % de la valeur prédite (% pred). Il s’associe à une altération de la membrane alvéolo-capillaire (DLCO corrigée sur l’hémoglobine à 31 % pred). Le patient a été récusé à la fois pour la transplantation médullaire et pour la transplantation pulmonaire malgré son jeune âge. La prise en charge est donc palliative : réhabilitation respiratoire, oxygénothérapie, puis nintedanib. Discussion Dans la littérature, les transplantations médullaires chez les patients présentant une mutation des télomérases s’associent à une dégradation de la fonction respiratoire, en lien avec la toxicité des traitements immunosuppresseurs, même en l’absence d’atteinte pulmonaire initiale. Par ailleurs, les complications infectieuses et hématologiques post-transplantations pulmonaires chez ces patients mutés semblent plus fréquentes et nécessitent souvent une adaptation des traitements anti-rejets. Ces risques post-transplantations paraissent plus importants en présence d’une thrombopénie sévère préopératoire. Ces données sont cependant limitées à trois études rétrospectives de petites tailles. Au total, ce jeune patient a été jugé inéligible à la transplantation médullaire et à la transplantation pulmonaire, respectivement à cause de l’insuffisance respiratoire et de l’insuffisance médullaire. Il est émis l’hypothèse que l’allègement de la thérapie immunosuppressive pourrait améliorer le devenir des patients mutés transplantés, sans majorer le risque de rejet, illustrant le concept d’immunosénescence. Mais cette hypothèse reste à être validée. Ce cas clinique souligne l’importance de reconnaître les signes évocateurs de téloméropathie, dans la mesure où le diagnostic impacte la prise en charge de la fibrose pulmonaire
ISSN: 0761-8425

hal-01334065
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01334065
DOI : 10.1016/j.rmr.2016.04.018

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
MR and MDHD contributed equally to this work. Summary Painful vaso-occlusive crisis, a hallmark of sickle cell anaemia, results from complex, incompletely understood mechanisms. Red blood cell (RBC) damage caused by continuous endogenous and exogenous oxidative stress may precipitate the occurrence of vaso-occlusive crises. In order to gain insight into the relevance of oxidative stress in vaso-occlusive crisis occurrence , we prospectively compared the expression levels of various oxidative markers in 32 adults with sickle cell anaemia during vaso-occlusive crisis and steady-state conditions. Compared to steady-state condition, plasma levels of free haem, advanced oxidation protein products and myeloperoxi-dase, RBC caspase-3 activity, as well as the concentrations of total, neutrophil-and RBC-derived microparticles were increased during vaso-occlusive crises, whereas the reduced glutathione content was decreased in RBCs. In addition, natural anti-band 3 autoantibodies levels decreased during crisis and were negatively correlated with the rise in plasma advanced oxidation protein products and RBC caspase-3 activity. These data showed an exacerbation of the oxidative stress during vaso-occlusive crises in sickle cell anaemia patients and strongly suggest that the higher concentration of harmful circulating RBC-derived microparticles and the reduced anti-band 3 autoantibodies levels may be both related to the recruitment of oxidized band 3 into membrane aggregates.
ISSN: 0007-1048

inserm-01476067
http://www.hal.inserm.fr/inserm-01476067
http://www.hal.inserm.fr/inserm-01476067/document
http://www.hal.inserm.fr/inserm-01476067/file/2016%2C%20Hierso%20-%20Exacerbation%20of%20oxidative%20stress%20during%20sickle%20vaso-occlusive%20crisis.pdf
DOI : 10.1111/bjh.14476

Éditeur(s) : Pêche thonière et dispositifs de concentration de poissons, Caribbean-Martinique, 15-19 Oct 1999 15-19 octobre 1999
Résumé : The development of the FAD gave rise to technical problems owing to their conception, their setting spot and of their utilisation. Failings generated by the unreliability of components or the uncertain repair precariousness, those can prove to be here more and more expensive with the progression of the ageing of devices and reasons of their loss. For as various domains that aerospace or the fishing deck layout, the engineering has functional analysis tools that permit to reduce conception uncertainties of systems by the mean of a hierarchical classification of function values of components. The application of one of these techniques, the FMEA, Failure Mode and Effects Analysis, to the study of reasons of FAD loss in La Reunion describes perfectly everything that this type of method can bring to the appraisal in fishing technology. This preventive analysis method assess the potential risks integrates perfectly in the mind of a precaution approach as it would agree to see to apply to the FADs and to their exploitation.Original Abstract: Le developpement des DCP a entraine l'apparition de problemes techniques, issus tant de leur conception, de leur lieu d'implantation que de leur utilisation. Defaillances generees par le manque de fiabilite des composants ou la precarite de reparations aleatoires, celles-ci peuvent s'averer de plus en plus couteuses au fur et a mesure du vieillissement des systemes et cause a terme de leur perte. Pour des domaines aussi divers que l'aerospatiale ou l'amenagement de pont de peche, l'ingenierie dispose d'outils d'analyse fonctionnelle qui, par le biais d'une hierarchisation des valeurs des fonctions de chaque element des systemes etudies, permettent de reduire les incertitudes de la conception. L'application d'une de ces techniques, l'Amdec, analyse des modes de defaillance et de criticite, a l'etude des causes des pertes de DCP a La Reunion illustre parfaitement tout ce que ce type de methode peut apporter a l'expertise en technologie des peches. Cette methode d'analyse preventive qui recense et met en evidence les risques potentiels s'integre parfaitement dans l'esprit d'une approche de precaution telle que celle qu'il conviendrait de voir appliquer aux DCP et a leur exploitation.

Droits : Ifremer
http://archimer.ifremer.fr/doc/00042/15289/12675.pdf
http://archimer.ifremer.fr/doc/00042/15289/

Éditeur(s) : HAL CCSD
Résumé : Ocean Drilling Program Hole 1256D reached for the first time the transition zone between the sheeted dike complex and the uppermost gabbros. The recovered crustal section offers a unique opportunity to study the deepest part of the hydrothermal system in present-day oceanic crust. We present a structural analysis of electrical borehole wall images. We identified, and measured the orientations of four categories of structures: major faults, minor fractures, possibly hydrothermal veins, and dikes. All structures tend to strike parallel to the paleo-ridge axis. Three major fault zones (meter thick) and dikes are steeply dipping (~ 75° on average) outward the ridge. Centimeter-thick moderately conductive planar features are interpreted as hydrothermal veins, are organized in arrays of consistent spacing, thickness, and orientation, and are dipping about 15-20° toward the ridge. This structural pattern is interpreted as an on-axis paleohydrothermal circulation system, with vertical, dike-parallel fractures, and sub-horizontal high-temperature hydrothermal veins at the base of the sheeted dike, which was subsequently rotated ~ 15° westward around a ridge-parallel, sub-horizontal axis. This rotation can be caused by upper-crustal block rotation along a listric normal fault, and/or subsidence at the ridge axis.
Ofioliti

hal-00757592
https://hal.archives-ouvertes.fr/hal-00757592
DOI : 10.4454/ofioliti.v37i1.402