Éditeur(s) : HAL CCSD
Résumé : National audience
INTRODUCTION: Pulmonary arterial hypertension (PAH) is a severe complication of systemic sclerosis and detecting PAH efficiently remains challenging. The DETECT study has offered in 2013 a composite screening tool for PAH. The objective of our study was to compare the indication of right heart catheterisation (RHC) as suggested by the DETECT algorithm with the decisions of a multidisciplinary team. METHODS: This prospective monocentric non-interventional study consecutively included systemic sclerosis patients when data required to apply DETECT algorithm were available. We evaluate the number of RHC as requested by this algorithm and confronted it with the indications of RHC suggested by a multidisciplinary group blinded for the result of DETECT algorithm. RESULTS: In total, 117 systemic sclerosis patients were included. When DETECT algorithm was applied to all patients, RHC was suggested by this algorithm for 70 patients, whereas only 15 indications were required by the multidisciplinary group; among those patients only 7 had PAH. When DETECT algorithm was applied only to the 42 patients with DLCO<60% and disease duration of more than 3 years, RHC was suggested for 31 patients whereas only 13 were indicated by the multidisciplinary group; among those patients only 7 had PAH. CONCLUSION: The DETECT algorithm is able to efficiently detect all PAH patients finally diagnosed by our multidisciplinary team. However, it increases by 3 the number of RHC that should be performed.
La Revue de Médecine Interne

hal-01579606
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01579606
DOI : 10.1016/j.revmed.2017.04.005
PUBMED : 28545856

Résumé : L'objectif principal était d'établir un bilan des améliorations et de la logistique nécessaire dans l’éventualité d’un recours à des échantillonneurs passifs pour l’évaluation des niveaux de contamination chimique des eaux dans le contexte hydrodynamique et biogéochimique de la Guyane. Dans ce sens, une action de formation à la mise en place des techniques d'échantillonnage passif et une campagne "terrain" (sur 10 sites) a été réalisée. Cette campagne a permis de fournir les premières mesures de concentrations de nombreux contaminants chimiques (métaux, composés organiques dans les eaux littorales guyanaises. En plus des techniques DGT et SBSE (déjà mises en oeuvre en 2008), des échantillonneurs passifs pour les composés hydrophiles (POCIS) ont aussi été utilisés. Cette étude montre l'opérationnalité de ces systèmes qui permettent d'atteindre les limites de détection requises par la DCE et de mesurer des contaminants présents à l’état de trace et qui n'auraient pas pu être détectés par les méthodes classiques (notamment pour les composés organiques). Ces techniques "tout terrain" permettent aussi de réduire les coûts et d’améliorer la rapidité d'obtention des résultats, de faciliter la mise en oeuvre. Ces techniques ont pu être transférées aux acteurs (préalablement formés) en charge de la surveillance de l'état de la contamination chimique des eaux. Les résultats ont contribué à la caractérisation des masses d'eau guyanaises par rapport à certains contaminants chimiques (métaux, composés organiques hydrophiles et hydrophobes) et mis en évidence de la présence, ou l’absence, de certains composés émergents sur lesquels il n'y avait encore aucune donnée. Les concentrations en métaux (DGT) des différentes masses d'eau indiquent que dans l'ensemble il n’y a pas d'anomalies particulières par rapport à des environnements où la contamination est avérée. Les résultats obtenus par la technique POCIS sont parmi les premiers disponibles en milieu marin côtier. Ils indiquent la présence à de faibles niveaux de concentrations, de substances comme les pesticides (diuron et terbuthylazine), de substances pharmaceutiques (caféine, théophylline, carbamazépine, terbutaline) et d'alkylphénols. La technique SBSE a permis de mettre en évidence la présence de certains composés à des concentrations très faibles Des concentrations notables en endosulfan ont été mesurées à la station de Montsinéry grâce à cette technique.

Droits : 2012 Ifremer
http://archimer.ifremer.fr/doc/00071/18206/15773.pdf
http://archimer.ifremer.fr/doc/00071/18206/

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
The diagnosis of diabetic foot infections is difficult due to limitations of conventional culture-based techniques. The objective of this study was to evaluate the contribution of denaturing gradient gel electrophoresis (DGGE) in the microbiological diagnosis of diabetic foot ulcers in comparison to conventional techniques, and also to evaluate the need to perform a biopsy sample for this diagnosis. Twenty diabetic patients (types 1 and 2) with foot ulcers (grades 1-4) were included. After debridement of their wounds, samples were taken in duplicate by surface swabbing and deep-tissue biopsy. The samples were analyzed by conventional culture and by a new molecular biology tool, DGGE technology. Polymerase chain reaction (PCR)-DGGE led to the identification of more bacteria than did conventional cultures (mean: 2.35 vs 0.80, respectively). In 11 cases, the technology detected pathogenic species not isolated by classical cultures. PCR-DGGE also identified significantly more pathogenic species at deep levels compared with species detected at superficial levels (87% vs 58%, respectively; P = 0.03). In 9/20 cases, pathogenic bacteria were detected only in deep samples, revealing the need to perform tissue biopsy sampling. DGGE, achievable in 48h, could be a useful technique for the bacteriological diagnosis of diabetic foot infections. It may help to identify pathogenic bacteria in deeply infected ulcers, thereby contributing to a more appropriate use of antibiotics.
ISSN: 1262-3636

hal-01122240
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01122240
DOI : 10.1016/j.diabet.2014.03.002
PUBMED : 24751989

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
BACKGROUND: In Guadeloupe and Martinique, two French Overseas Departments, colorectal cancer (CRC) has become an essential public health issue. However, little is known about CRC characteristics and the p53 status in these populations, particularly in Guadeloupe, whereas certification of a cancer registry has been recently validated. METHODS: This was a descriptive retrospective study of 201 patients who, between 1995 and 2000, underwent surgery for CRC in the Guadeloupe Teaching Hospital (GlpeTH; 83 patients) and in the Martinique Teaching Hospital (MqueTH; 118 patients). The clinicopathological features and the p53 expression, evaluated with immunohistochemistry, were compared at the time of diagnosis. A relationship between these parameters and the p53 expression was also studied. Data were analysed, using the SPSS computer software version 17.0. RESULTS: No statistical difference was found between the two groups of patients regarding age (p = 0.60), percentage of young patients (<=50 years; p = 0.94)), sex (p = 0.47), histological type (p = 0.073) and tumour sites (p = 0.65), although the GlpeTH patients were diagnosed with more distal colon cancers (54.2%) than the Mque TH patients (47.4%). By contrast, a significant difference was found regarding the tumour grade (p < 0.0001), the pTNM stage (p = 0.045) and the pT stage (p < 0.0001). Regarding p53 expression, solely for the MqueTH patients, nuclear expression was associated with pTNM, the percentage of p53 negative tumours increasing with the progression of the pTNM stages (p = 0.029). CONCLUSIONS: For the first time, this study reveals discrepancies in clinicopathological features and in the p53 status between the two groups of patients. The GlpeTH patients were diagnosed with more moderated CRCs but with few CRCs at pTNM IV stage. By contrast, the MqueTH patients were diagnosed with more differentiated tumours, but with many more CRCs at pTNM IV stage. This paradox may be due to differences in tumour location (distal vs proximal), multiplicity of the genetic profiles of patients, or patients getting treatment elsewhere. Although our study is limited due to its small size, it emphasizes the originality of our results.
ISSN: 1472-6890

inserm-00971313
http://www.hal.inserm.fr/inserm-00971313
http://www.hal.inserm.fr/inserm-00971313/document
http://www.hal.inserm.fr/inserm-00971313/file/1472-6890-14-12.pdf
DOI : 10.1186/1472-6890-14-12

Éditeur(s) : HAL CCSD MDPI
Résumé : International audience
The decline in children's Blood Lead Levels (BLL) raises questions about the ability of current lead poisoning screening criteria to identify those children most exposed. The objectives of the study were to evaluate the performance of current screening criteria in identifying children with blood lead levels higher than 50 µg/L in France, and to propose new criteria. Data from a national French survey, conducted among 3831 children aged 6 months to 6 years in 2008-2009 were used. The sensitivity and specificity of the current criteria in predicting blood lead levels higher than or equal to 50 µg/L were evaluated. Two predictive models of BLL above 44 µg/L (for lack of sufficient sample size at 50 µg/L) were built: the first using current criteria, and the second using newly identified risk factors. For each model, performance was studied by calculating the area under the ROC (Receiver Operating Characteristic) curve. The sensitivity of current criteria for detecting BLL higher than or equal to 50 µg/L was 0.51 (0.26; 0.75) and specificity was 0.66 (0.62; 0.70). The new model included the following criteria: foreign child newly arrived in France, mother born abroad, consumption of tap water in the presence of lead pipes, pre-1949 housing, period of construction of housing unknown, presence of peeling paint, parental smoking at home, occupancy rates for housing and child's address in a cadastral municipality or census block comprising more than 6% of housing that is potentially unfit and built pre-1949. The area under the ROC curve was 0.86 for the new model, versus 0.76 for the current one. The lead poisoning screening criteria should be updated. The risk of industrial, occupational and hobby-related exposure could not be assessed in this study, but should be kept as screening criteria
ISSN: 1660-4601

hal-01239804
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01239804
DOI : 10.3390/ijerph121214989
PUBMED : 26633457

Éditeur(s) : HAL CCSD
Résumé : The bacterial microbiota of ants (Hymenoptera: Formicidae) is known to have a defensive role in social insects, particularly for leaf-cutting ants (Formicidae: Attini) due to the use of antimicrobial molecules produced by cuticular actinobacteria. In this thesis, we studied the bacterial microbiota of ants in French Guyana using different approaches based on natural products chemistry and molecular ecology. The first chapter describes the isolation, identification, culture and biological evaluations of 43 cuticular actinobacteria. Antagonism bioassays of isolated strains and antibiotic activities of the culture extracts against human pathogens are presented as well as the identification of an antimicrobial cyclic dipeptide (Cyclo (LPro-LPhe)) isolated from a strain close to Streptomyces thioluteus. Moreover, the implementation of molecular networks applied to UPLC/MS/MS analysis of actinobacterial cocultures allowed us to explore the diversity of metabolites produced under these conditions. The second chapter presents a methodological study to evaluate the capacity of four DNA extraction methods, in terms of richness and composition of the cuticular bacterial microbiota, in high-throughput sequencing from Atta cephalotes and Pseudomyrmex penetrator. The results of metabarcoding highlight two methods of extraction and reveal inter- and intraspecific differences in the composition of cuticular bacterial communities. Finally, chapter three describes the composition of the cuticular bacterial microbiota of Camponotus femoratus and Crematogaster levior in ant garden and the results reveal the acquisition in the environment of a part of the microbiota. In parallel, metabolomic analyses of ant’s cuticle show, on the contrary, a greater specificity related to the ant species. Future researches focusing on statistical analysis strategies combining metabarcoding and metabolomics data are discussed.
Le microbiote bactérien cuticulaire des fourmis (Hymenoptera : Formicidae) est connu pour avoir un rôle défensif chez ces insectes sociaux, notamment chez les fourmis attines (Formicidae : Attini) grâce l’utilisation de molécules antimicrobiennes produites par des actinobactéries cuticulaires. Dans le cadre de cette thèse, nous avons étudié le microbiote bactérien des fourmis de Guyane en utilisant différentes approches en chimie des produits naturels et en écologie moléculaire. Le premier chapitre décrit l’isolement, l’identification, la culture et l’évaluation biologique de 43 actinobactéries cuticulaires de fourmis de Guyane. Les tests d’antagonismes des souches isolées et l’activité antibiotique des extraits de culture contre des micro-organismes pathogènes humains sont présentés ainsi que l’identification d’un dipeptide cyclique (Cyclo(LPro-LPhe)) antimicrobien qui a été isolé à partir d’une souche proche de Streptomyces thioluteus. Par ailleurs, la mise en œuvre de réseaux moléculaires appliqués à une analyse par UPLC/MS/MS de cocultures d’actinobactéries a permis d’explorer la diversité des métabolites produits dans ces conditions. Le deuxième chapitre présente une étude méthodologique pour comparer quatre méthodes d’extraction d’ADN, en termes de richesse et de composition du microbiote bactérien cuticulaire, par séquençage haut débit à partir des espèces Atta cephalotes et Pseudomyrmex penetrator. Les résultats du métabarcoding ADN mettent en lumière deux méthodes d’extraction et révèlent des différences inter- et intraspécifiques dans la composition des communautés bactériennes cuticulaires. Enfin, le chapitre trois décrit la composition du microbiote bactérien cuticulaire des espèces Camponotus femoratus et Crematogaster levior dans les jardins de fourmis. Les résultats soulignent l’acquisition d’une partie du microbiote dans l’environnement. En parallèle l’analyse métabolomique des cuticules montre à contrario une plus grande spécificité liée à l’espèce de fourmi. Les recherches futures axées sur les stratégies d’analyses statistiques combinant le métabarcoding et la métabolomique sont discutées.
https://tel.archives-ouvertes.fr/tel-01537793

NNT : 2017YANE0003
tel-01537793
https://tel.archives-ouvertes.fr/tel-01537793
https://tel.archives-ouvertes.fr/tel-01537793/document
https://tel.archives-ouvertes.fr/tel-01537793/file/thesecarolinebirer.pdf

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
We use first first-principle methods and the Peierls-Nabarro model to evaluate the resistance to glide, characterized by the Peierls stress, of glide systems for end-member MgSiO3 Perovskite at mantle pressures. [010](100) is the easiest glide system in Mg-Perovskite at all pressures. Peierls stresses increase systematically with pressure for all systems except [001](010), indicating the importance of lattice friction at lower mantle pressures. The ratio of the maximum Peierls stress for each system relative to the [010](100) value defines their critical resolved shear stress (CRSS). These CRSS are used in a visco-plastic self-consistent homogenization model to predict the evolution of crystal preferred orientations (CPO) during deformation of polycrystalline Mg-Perovskite. In axial compression, [100] tends to align with the compression direction, in agreement with in situ observations in axial compression experiments. In simple shear, [010] concentrates near the shear direction and (100), although more dispersed, tends to align near the shear plane, consistent with the dominant activity of the easier [010](100) system. The calculated seismic anisotropy for a 100% Mg-Perovskite aggregate using the CPO in simple shear and the elastic constants Of MgSiO3 perovskite at lower mantle pressures and temperatures is weak (>3% for P-waves with and >2% for S-waves) and decreases with increasing temperature and pressure. P-waves show the fastest propagation parallel to the lineation and S-waves fast polarization is in the foliation at 38 GPa and normal to the lineation at 88 GPa. This weak anisotropy is consistent with global seismological observations of a nearly isotropic lower mantle. There are however two regions where strain-induced Mg-Perovskite CPO could contribute to anisotropy; a) low temperature regions in the uppermost lower mantle, where the predicted S-wave polarization anisotropy may attain 1.6% with a fast polarization parallel to the foliation, b) in high high-temperature domains in the D '' layer, where Mg-Perovskite may be the major stable phase, leading to polarization of fast S-waves normal to the lineation for propagation directions at high angle to the lineation and an apparent isotropy for all other propagation directions.
ISSN: 0012-821X

hal-00411460
https://hal.archives-ouvertes.fr/hal-00411460
DOI : 10.1016/j.epsl.2008.03.058

Éditeur(s) : Université Bretagne Ouest
Résumé : This work deals with the fishing effects on the diversity dynamics of demersal fish communities, focusing on the biotic interactions. Multispecies indices are used in order to characterize the demersal fish community dynamics of the Bay of Biscay and of the Gulf of Lions. These are the diversity indices, the temporal variability of the total biomass and of the slope of the number size spectra and the slope of the species-area curves (spatial segregation). The yearly bottom trawl surveys EVHOE, CHALIST and MEDITS, carried out in these two areas since 1983 by IFREMER for the stocks assessment provide the data. The differences between areas are related to a fishing index (mean value of the annual landings of demersal fish per surface area). Other areas are included in the analysis when the index values are available from the published literature (North Sea, Scotian Shelf, Kenya, French Guyana). It is argued from the diversity indices analysis that the Gulf of Lions community is more diverse and less disturbed than the Bay of Biscay one. This result is not consistent with a fishing effect but with biogeography. The total biomass variability and the slope variability of size spectra are higher in the most harvested areas than in the least ones. On the contrary, the species-area slope is the lowest in the most harvested areas. Theoretically, biotic interactions decrease the total biomass variability and the spectra slope variability because of compensations and increase the species area slope because of competitive exclusion. It is concluded that harvesting alters biotic interactions and favour local coexistence by decreasing competitive exclusion. The species diversity maintenance depends on competitive exclusion. Hence, biodiversity is threatened not only by a direct fishing effect but also by a dynamics alteration.
Ce mémoire aborde le problème de l'impact de l'exploitation par la pêche sur la dynamique de diversité des peuplements de poissons démersaux. Les effets de la pêche sur le rôle des interactions biotiques entre espèces dans la dynamique des peuplements sont plus particulièrement analysés à l'aide de descripteurs multispécifiques. Les descripteurs utilisés sont les indices de diversité, la variabilité temporelle de la biomasse totale et de la pente multispécifique du spectre de poids et la pente des droites d'accumulation d'espèces mesurant la ségrégation spatiale. Les valeurs de ces indices sont calculées à partir des données de campagnes annuelles de chalutage de fond EVHOE, CHALIST et MEDITS, menées par l'IFREMER depuis 1983 pour l'évaluation des ressources halieutiques dans le golfe de Gascogne et dans le golfe du Lion. Les différences de caractéristiques de dynamique entre les deux peuplements révélées par ces descripteurs sont mises en relation avec un indice d'exploitation (valeur moyenne des débarquements annuels, divisée par la surface du plateau de la région concernée). D'autres régions ont été intégrées dans cette analyse lorsque les valeurs des indicateurs étaient disponibles dans la littérature (Mer du Nord, plateau de Nouvelle-Ecosse, Kenya et Guyane Française). Les indices de diversité utilisés permettent de mettre en évidence que le peuplement du golfe du Lion est plus diversifié et moins soumis à perturbations que celui du golfe de Gascogne. Ces caractéristiques semblent dues à l'histoire biogéographique de ces deux régions et non à un effet de la pêche. La variabilité de la biomasse totale et celle de la pente du spectre multispécifique augmentent depuis les régions les moins exploitées vers les plus exploitées. A l'inverse, la ségrégation spatiale diminue. En théorie, les interactions entre espèces diminuent la variabilité temporelle de la biomasse totale et de la pente du spectre multispécifique, à cause de compensations entre espèces, et augmentent la ségrégation spatiale par exclusion compétitive. L'interprétation donnée des résultats obtenus est ainsi une altération des interactions entre les espèces par l'exploitation. En prélevant de la biomasse, l'exploitation augmente la disponibilité des ressources pour les individus non pêchés. En conséquence, l'exclusion compétitive diminue et la coexistence locale des individus est facilitée. A long terme, la diversité est donc menacée, non seulement par raréfaction des espèces prélevées par l'exploitation mais aussi parce que les interactions sont altérées et que le maintien de la diversité en dépend pour partie.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/2000/these-6670.pdf
http://archimer.ifremer.fr/doc/00000/6670/

Éditeur(s) : HAL CCSD
Résumé : International audience
Home health care workers interventions have been implemented in western countries to improve health status of patients with respiratory diseases especially asthma and allergic illnesses. Twenty-six controlled studies dealing with prevention and control of these diseases through home environmental interventions were reviewed. After a comprehensive description of the characteristics of these studies, the effectiveness of each intervention was then evaluated in terms of participants' compliance with the intervention program, improvement of quality of the indoor environment, and finally improvement of health outcomes, in detailed tables. Limitations and biases of the studies are also discussed. Overall, this review aims at giving a toolbox for home health care workers to target the most appropriate measures to improve health status of the patient depending on his and/or her environment and disease. Only a case-by-case approach with achievable measures will warrant the efficacy of home interventions. This review will also provide to the research community a tool to better identify targets to focus in future evaluation studies of home health care workers action.
Journal of allergy and clinical immunology. In practice

hal-01477202
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01477202
DOI : 10.1016/j.jaip.2016.07.011
PUBMED : 27665387

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Diagnosis of toxoplasmic encephalitis (TE) in patients with AIDS is not straightforward because clinicians rely initially on an empiric diagnosis based on clinical and radiographic improvement to specific anti-Toxoplasma gondii therapy. There is therefore a need for biological tools to improve the diagnosis of TE, especially in tropical areas where this diagnosis is likely to be underestimated. The use of PCR testing in blood samples for the diagnosis of TE has been limited by its poor sensitivity in the studies conducted in Europe. In tropical South America, the results of PCR sensitivity in blood samples were controversial. Considering that T. gondii strains from tropical South America have substantial genetic and pathogenic differences with those from USA and Europe, it is therefore important to re-evaluate the performance of the PCR assay in blood samples for the diagnosis of TE in AIDS patients from this region. Our results showed that the only interest of PCR would be in the most severe forms of TE with altered consciousness because PCR is more likely to be positive. We also provided important genotyping data on T. gondii strains isolated in human cases of toxoplasmosis in the Caribbean and in South America.
ISSN: 1935-2727

hal-01503761
https://hal-unilim.archives-ouvertes.fr/hal-01503761
https://hal-unilim.archives-ouvertes.fr/hal-01503761/document
https://hal-unilim.archives-ouvertes.fr/hal-01503761/file/journal.pntd.0004790.pdf
DOI : 10.1371/journal.pntd.0004790

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
Background: Heterogeneous patterns of malaria transmission are thought to be driven by factors including host genetics, distance to mosquito breeding sites, housing construction, and socio-behavioural characteristics. Evaluation of local transmission epidemiology to characterize malaria risk is essential for planning malaria control and elimination programmes. The use of geographical information systems (GIS) techniques has been a major asset to this approach. To assess time and space distribution of malaria disease in Bandiagara, Mali, within a transmission season, data were used from an ongoing malaria incidence study that enrolled 300 participants aged under six years old ". Methods: Children's households were georeferenced using a handheld global position system. Clinical malaria was defined as a positive blood slide for Plasmodium falciparum asexual stages associated with at least one of the following signs: headache, body aches, fever, chills and weakness. Daily rainfall was measured at the local weather station. Landscape features of Bandiagara were obtained from satellite images and field survey. QGIS™ software was used to map malaria cases, affected and non-affected children, and the number of malaria episodes per child in each block of Bandiagara. Clusters of high or low risk were identified under SaTScan W software according to a Bernoulli model. Results: From June 2009 to May 2010, 296 clinical malaria cases were recorded. Though clearly temporally related to the rains, Plasmodium falciparum occurrence persisted late in the dry season. Two " hot spots " of malaria transmission also found, notably along the Yamé River, characterized by higher than expected numbers of malaria cases, and high numbers of clinical episodes per child. Conversely, the northeastern sector of the town had fewer cases despite its proximity to a large body of standing water which was mosquito habitat. Conclusion: These results confirm the existence of a marked spatial heterogeneity of malaria transmission in Bandiagara, providing support for implementation of targeted interventions. Background Malaria is one of the leading causes of morbidity and mortality in the world, with an estimated 3.3 billion people at risk of malaria [1]. The incidence of malaria worldwide is estimated to be 216 million cases per year, with 81% of these cases occurring in sub-Saharan Africa. Malaria kills approximately 655,000 people per year; 91% of deaths occur in sub-Saharan Africa [1], mostly in children under five years of age. In Mali, West Africa, malaria represents 36.5% of consultation motives in health center, it is a leading cause of morbidity and mortality children of less than five years of age and the first reason of anaemia in pregnant women [2]. Malaria transmission is seasonal. Malaria parasite transmission and clinical disease are characterized by important microgeographic variation, often between adjacent villages, households or families [3-8]. This local heterogeneity is driven by a variety of factors including human genetics [9,10], distance to potential breeding sites [11,12], housing construction
ISSN: 1475-2875

hal-01307672
https://hal-amu.archives-ouvertes.fr/hal-01307672
https://hal-amu.archives-ouvertes.fr/hal-01307672/document
https://hal-amu.archives-ouvertes.fr/hal-01307672/file/1475-2875-12-82.pdf
DOI : 10.1186/1476-072X-2-5

Résumé : Fishing activity in the french mediterranean lagoon Etang de Berre is actually allowed in spite of a degradation of the environment during the last fifty years. To analyse the results and the working of the fishery, a study based on a sampling survey of catches and fishing effort has been conducted in the various landing ports over a two years period. Annual weight and value productions by species and gear have been evaluated by mean of statistical calculation procedures. The results show that the fishery is based on the exploitation of two main species (anguilla and grey mullet) and that important variations exist between the two sampled years. The limits to be reached by the working of this fishery are prompted in the scope of a future regulation.
La pratique de l'exploitation halieutique dans l'étang lagunaire de Berre (Méditerranée française) est actuellement tolérée malgré la dégradation du milieu au cours des cinquante dernières années. Pour réaliser une analyse des résultats et du fonctionnement de la pêcherie, une étude par enquête basée sur le suivi des captures et des efforts de pêche a été menée aux différents ports de débarquements pendant une durée de deux ans. On calcule par évaluation les productions annuelles spécifiques et par métiers, en poids et en valeurs. Ces résultats montrent que la pêcherie est basée sur l'exploitation de deux espèces principales (anguille et mulets) et qu'il existe de fortes variations entre les deux années d'études. Dans l'optique d'une réglementation on suggère les limites résultant du mode de fonctionnement de cette pêcherie.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/1989/rapport-1569.pdf
http://archimer.ifremer.fr/doc/00000/1569/

Éditeur(s) : HAL CCSD
Résumé : International audience
BACKGROUND: The effects of pressure-controlled (PC) ventilation on the ventilatory and haemodynamic parameters during laparoscopy procedures had not been carefully assessed. This prospective cross-over study was undertaken to compare how volume-controlled (VC) and PC modes could affect pulmonary mechanics, gas exchange, and cardiac function in patients undergoing laparoscopy. METHODS: Twenty-one patients undergoing laparoscopic urological procedures had their lungs ventilated at the beginning with VC ventilation. PC ventilation was instituted at the end of the VC sequence. Ventilator settings were adjusted to keep tidal volume, respiratory rate, and Fi(o(2)) constant in every mode. A complete set of ventilatory, haemodynamic, and gas exchange parameters was obtained under VC after 40 min of pneumoperitoneum and 20 min after switching for PC. Transoesophageal echocardiography was performed in order to evaluate systolic and diastolic function of the heart. RESULTS: When VC was switched to PC, peak airway pressure decreased [mean (sd) 32 (6) vs 27 (6) cm H(2)O; P < 0.0001], peak inspiratory flow increased [17 (3) vs 48 (8) litre min(-1); P < 0.0001), and dynamic compliance improved [+15 (8)%]. No difference was noted for static airway pressure, static compliance, and arterial oxygenation. No significant change could be demonstrated in the systolic [left ventricular end-systolic wall stress 66 (16) vs 63 (14) x 10(3) dyn cm(-2) m(-2)] or diastolic function [early diastolic velocity 10.3 (2.5) vs 10.5 (2.7) cm s(-1)]. CONCLUSIONS: In this study, no short-term beneficial effect of PC ventilation could be demonstrated over conventional VC ventilation in patients with pneumoperitoneum.
BJA

hal-00689758
https://hal.archives-ouvertes.fr/hal-00689758
DOI : 10.1093/bja/aem166
PUBMED : 17626027

Éditeur(s) : HAL CCSD Paris : L'Harmattan
Résumé : International audience
Les procédures que s’imposent les membres de l’association des certificateurs européens en langue, ALTE, dans le cadre de leur démarche qualité ont mis en évidence la dichotomie de cultures évaluatives distinctes. Cet article interroge les tensions méthodologiques inscrites dans une démarche qui semble ne pas être capable aujourd’hui de conjuguer inférence de compétences actionnelles en contexte et mesure de la validité et de la fiabilité, tout en soulignant qu’aucun des organismes en présence n’ignore cependant la préoccupation des autres, rendant sans doute possible le développement de recherches communes en ce sens.
ISSN: 1967-5798

Droits : info:eu-repo/semantics/OpenAccess
halshs-01395787
https://halshs.archives-ouvertes.fr/halshs-01395787
https://halshs.archives-ouvertes.fr/halshs-01395787/document
https://halshs.archives-ouvertes.fr/halshs-01395787/file/La%20d%C3%A9marche%20qualit%C3%A9%20chez%20les%20certificateurs%20europ%C3%A9ens%20en%20langues%20lieu%20de%20rencontre.pdf

Éditeur(s) : HAL CCSD CLE International
Résumé : International audience
Une interview de Patrick Riba par Sébastien Langevin, Rédacteur en chef de la revue "le français dans le monde"
ISSN: 0015-9395

halshs-01400374
https://halshs.archives-ouvertes.fr/halshs-01400374
https://halshs.archives-ouvertes.fr/halshs-01400374/document
https://halshs.archives-ouvertes.fr/halshs-01400374/file/Prendre_en_compte_la_dimension_ethique_de%20levaluation.pdf

Éditeur(s) : HAL CCSD AMIFRAM
Résumé : International audience
L'auteur ébauche ici un certain nombre de pistes didactiques afin d'améliorer l'évaluation en langues: pour une meilleure prise en compte de la validité de construit des épreuves, pour éviter les biais, pour améliorer la transparence des processus...Un plébiscite pour une démarche qualité en éducation.
ISSN: 2007-8986

Droits : info:eu-repo/semantics/OpenAccess
halshs-01400379
https://halshs.archives-ouvertes.fr/halshs-01400379
https://halshs.archives-ouvertes.fr/halshs-01400379/document
https://halshs.archives-ouvertes.fr/halshs-01400379/file/quelques%20r%C3%A9flexions%20sur%20l%27%C3%A9valuation%20en%20langues%2C%20comment%20faire%20mieux.pdf

Éditeur(s) : HAL CCSD
Résumé : Half-way between optimization and astronautic, this research study deals with satellites constel- lations design problems. In order to find the required number of satellites and to correctly set their position, such are the technical challenges of this thesis. To minimise the cost and reduce the time such are the economical challenges the space industries are confronted in a daily manner. The major difficulties of these problems are the size and the characteristics of the search space The irregularity of the criterions The mathematical and physical heterogeneity of parameters forbids the use of classical algorithms The evaluation of a solution, which uses a time consuming evalua- tion without returning pertinent information about the good or bad properties of the constellations, forbid a massive exploration of the search space. From this constatation and several preliminary studies a new approach is born. Based on a better use of the simulation and on a simplification of the criterions, the algorithm is composed of several levels and uses different optimization techniques it integrates a knowledge database on the orbits and a numerical optimization process both orchestrated by a metaheuristic algorithm. This new approach tries to bypass the main drawbacks of the field with a decomposition of the problem.
A mi-chemin entre l optimisation et l astronautique ce travail de recherche s attaque au problème du design de constellations de satellites Déterminer le nombre de satellites nécessaires pour ré- pondre à un besoin et les positionner de manière correcte tels sont les enjeux techniques de cette thèse Minimiser les coûts et les délais tels sont les enjeux économiques auxquels est confronté le domaine spatial au quotidien Les difficultés majeures de ce problème sont d une part la taille et les caractéristiques de l espace de recherche; D autre part la non-régularité des critères utilisés et la nature mathématique et phy- sique hétérogène de l ensemble des paramètres (paramètres entiers et paramètres réels) interdisant l utilisation d algorithmes classiques; Enfin l évaluation des solutions qui met en oeuvre une simu- lation coûteuse en temps et en calculs sans retourner d information pertinente sur les bonnes ou mauvaises propriétés de la constellation évaluée interdit une exploration massive de l espace de recherche De ces constatations et de diverses études préliminaires est née une nouvelle approche Basé sur une meilleure exploitation de la simulation et sur une simplification des critères utilisés l algorithme composé de plusieurs niveaux met en oeuvre plusieurs techniques d optimisation En intégrant une base de connaissance sur les orbites et une méthode numérique de recherche d optimum le tout or- chestré par un algorithme métaheuristique cette nouvelle approche tente de résoudre les difficultés intrinsèques au domaine d application en décomposant le problème.
https://tel.archives-ouvertes.fr/tel-00634769

tel-00634769
https://tel.archives-ouvertes.fr/tel-00634769
https://tel.archives-ouvertes.fr/tel-00634769/document
https://tel.archives-ouvertes.fr/tel-00634769/file/grandchamp_phd_2001.pdf

Éditeur(s) : Springer Berlin / Heidelberg
Résumé : The role of particles in the fate and speciation of trace metals in macrotidal estuaries was studied using a surface complexation model (MOCO). Cadmium was selected as the target metal contaminant due to its reactivity in estuaries: cadmium behavior is mainly controlled by heterogeneous processes (sorption/desorption) related to salinity and suspended matter gradients. Various scenarios of suspended matter distribution according to salinity were simulated. The impact of surface properties (specific surface area, density of surface sites, acido-basic properties, and complexation constant) was evaluated using data collected on particles from the Gironde, Loire, and Seine estuaries. Our results show that particle surface properties, evaluated on the basis of various parameters, are instrumental in "non-conservative" contaminant speciation in the estuarine environment. Their evaluation enables us to understand and simulate, to a large extent, the fate of "Cd-type" contaminants (whose behavior is controlled by competition between sorption and desorption processes). The natural variations of these properties can be responsible for significant modifications of the Cd speciation in the macrotidal estuaries where salinity and SM gradients are very strong.
The Handbook of Environmental Chemistry (1433-6839) (Springer Berlin / Heidelberg), 2006 , Vol. 5H , P. 265-301

Droits : 2006 Springer
http://archimer.ifremer.fr/doc/2006/publication-2005.pdf
DOI:10.1007/b89479
http://archimer.ifremer.fr/doc/00000/2005/

Éditeur(s) : Blackwell science
Résumé : This paper deals with the design of modelling tools suitable for investigating the consequences of alternative policies on the dynamics of resources and fisheries, such as the evaluation of marine protected areas (MPA). We first review the numerous models that have been developed for this purpose, and compare them from several standpoints: population modelling, exploitation modelling and management measure modelling. We then present a generic fisheries simulation model, Integration of Spatial Information for FISHeries simulation (ISIS-Fish). This spatially explicit model allows quantitative policy screening for fisheries with mixed-species harvests. It may be used to investigate the effects of combined management scenarios including a variety of policies: total allowable catch (TAC), licenses, gear restrictions, MPA, etc. Fisher's response to management may be accounted for by means of decision rules conditioned on population and exploitation parameters. An application to a simple example illustrates the relevance of this kind of tool for policy screening, particularly in the case of mixed fisheries. Finally, the reviewed models and ISIS-Fish are discussed and confronted in the light of the underlying assumptions and model objectives. In the light of this discussion, we identify desirable features for fisheries simulation models aimed at policy evaluation, and particularly MPA evaluation.
Fish and Fisheries (1467-2960) (Blackwell science), 2005-12 , Vol. 6 , N. 4 , P. 307-349

Droits : 2005 Blackwell Publishing, Inc
http://archimer.ifremer.fr/doc/2005/publication-1031.pdf
DOI:10.1111/j.1467-2979.2005.00199.x
http://archimer.ifremer.fr/doc/00000/1031/

Éditeur(s) : HAL CCSD
Résumé : International audience
The French education system remains highly centralized and only allows limited local adaptations for overseas territories. For example, if some laws (the last in 2013) allow the use of regional languages (e.g. Creole in the French West Indies) when they constitute a relevant contribution to the teaching, many official texts remain mainly based on the geographical, economical, historical, environment of the French mainland. We focus on some French BTS (Brevet de Technicien Supérieur / Advanced Technician Certificate), namely tourism and assistant manager, which are two important diplomas for the local development and in which microeconomic and management sciences plays a great part. The French BTS is a professional diploma prepared in two years after the “baccalauréat”, with national programs and evaluation criteria. The successful candidates are supposed to be immediately employable, especially in their local geographical environment. Thus, there exists a paradox between the national definition of the diploma and the local contexts of teaching. We discuss how teachers concretely deal with this situation on a day-to-day basis. Our hypothesis is that they act pragmatically, using their practical pedagogical content knowledge, without theoretical support for their action. In order to verify this hypothesis, we have conducted semi-structured interview with Guadeloupian teachers of the two aforementioned BTS. The main results shows that teachers adapt the national framework of the diploma, essentially by using local examples. This can be called a weak contextualization of the national texts. Indeed, these adaptations remain limited by fear of disadvantaging the students for the national exam. In addition, many context effects are shown, for example linked with local rules (concerning VAT, custom duties...) which are only partially taken into account by teachers. This demonstrates that the French educative system has not yet completely solved the opposition between national guideline and decentralization of the educational action.
19th General Meeting and Biennial Conference “Harnessing Science and Technology to create knowledge-base Economies and preserve Caribbean Ecosystems”
Tobago, Trinidad and Tobago

hal-01535045
https://hal.univ-antilles.fr/hal-01535045