Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
The purpose of this investigation was to characterize the management and prognosis of severe Pneumocystis jirovecii pneumonia (PJP) in human immunodeficiency virus (HIV)-negative patients. An observational cohort study of HIV-negative adults with PJP documented by bronchoalveolar lavage (BAL) through Gomori-Grocott staining or immunofluorescence, admitted to one intensive care unit (ICU) for acute respiratory failure, was undertaken. From 1990 to 2010, 70 patients (24 females, 46 males) were included, with a mean age of 58.6 ± 18.3 years. The mean Simplified Acute Physiology Score (SAPS)-II was 36.9 ± 20.4. Underlying conditions included hematologic malignancies (n = 21), vasculitis (n = 13), and solid tumors (n = 13). Most patients were receiving systemic corticosteroids (n = 63) and cytotoxic drugs (n = 51). Not a single patient received trimethoprim-sulfamethoxazole as PJP prophylaxis. Endotracheal intubation (ETI) was required in 42 patients (60.0 %), including 38 with acute respiratory distress syndrome (ARDS). In-ICU mortality was 52.9 % overall, reaching 80.9 % and 86.8 %, respectively, for patients who required ETI and for patients with ARDS. In the univariate analysis, in-ICU mortality was associated with SAPS-II (p = 0.0131), ARDS (p < 0.0001), shock (p < 0.0001), and herpes simplex virus (HSV) or cytomegalovirus (CMV) on BAL (p = 0.0031). In the multivariate analysis, only ARDS was associated with in-ICU mortality (odds ratio [OR] 23.4 [4.5-121.9], p < 0.0001). PJP in non-HIV patients remains a serious disease with high in-hospital mortality. Pulmonary co-infection with HSV or CMV may contribute to fatal outcome.
ISSN: 0934-9723

inserm-00872789
http://www.hal.inserm.fr/inserm-00872789
DOI : 10.1007/s10096-012-1730-7
PUBMED : 22930407

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
IntroductionLeishmania RNA virus type 1 (LRV1) is an endosymbiont of some Leishmania (Vianna) species in South America. Presence of LRV1 in parasites exacerbates disease severity in animal models and humans, related to a disproportioned innate immune response, and is correlated with drug treatment failures in humans. Although the virus was identified decades ago, its genomic diversity has been overlooked until now.Methodology/Principles findingsWe subjected LRV1 strains from 19 L. (V.) guyanensis and one L. (V.) braziliensis isolates obtained from cutaneous leishmaniasis samples identified throughout French Guiana with next-generation sequencing and de novo sequence assembly. We generated and analyzed 24 unique LRV1 sequences over their full-length coding regions. Multiple alignment of these new sequences revealed variability (0.5%±23.5%) across the entire sequence except for highly conserved motifs within the 5' untranslated region. Phylogenetic analyses showed that viral genomes of L. (V.) guyanensis grouped into five distinct clusters. They further showed a species-dependent clustering between viral genomes of L. (V.) guyanensis and L. (V.) braziliensis, confirming a long-term co-evolutionary history. Noteworthy, we identified cases of multiple LRV1 infections in three of the 20 Leishmania isolates.Conclusions/SignificanceHere, we present the first-ever estimate of LRV1 genomic diversity that exists in Leishmania (V.) guyanensis parasites. Genetic characterization and phylogenetic analyses of these viruses has shed light on their evolutionary relationships. To our knowledge, this study is also the first to report cases of multiple LRV1 infections in some parasites. Finally, this work has made it possible to develop molecular tools for adequate identification and genotyping of LRV1 strains for diagnostic purposes. Given the suspected worsening role of LRV1 infection in the pathogenesis of human leishmaniasis, these data have a major impact from a clinical viewpoint and for the management of Leishmania-infected patients.
ISSN: 1935-2727

pasteur-01583523
https://hal-riip.archives-ouvertes.fr/pasteur-01583523
DOI : 10.1371/journal.pntd.0005764
PUBMED : 28715422

Éditeur(s) : Amer Geophysical Union
Résumé : New high-resolution multichannel seismic data (GWADASEIS-2009 and JC45/46-2010 cruises; 72 and 60 channels, respectively) combined with previous data (AGUADOMAR-1999 and CARAVAL-2002; 6 and 24 channels, respectively) allow a detailed investigation of mass-wasting processes around the volcanic island of Montserrat in the Lesser Antilles. Seven submarine deposits have sources on the flanks of Montserrat, while three are related to the nearby Kahouanne submarine volcanoes. The most voluminous deposit (similar to 20 km(3)) within the Bouillante-Montserrat half-graben has not been described previously and is probably related to a flank instability of the Centre Hills Volcano on Montserrat, while other events are related to the younger South Soufriere Hills-Soufriere Hills volcanic complex. All deposits are located to the south or southeast of the island in an area delimited by faults of the Bouillante-Montserrat half-graben. They cover a large part of the southeast quarter of the surrounding seafloor (similar to 520 km(2)), with a total volume of similar to 40 km(3). Our observations suggest that the Bouillante-Montserrat half-graben exerts a control on the extent and propagation of the most voluminous deposits. We propose an interpretation for mass-wasting processes around Montserrat similar to what has happened for the southern islands of the Lesser Antilles.
Geochemistry Geophysics Geosystems (1525-2027) (Amer Geophysical Union), 2011-05 , Vol. 12 , N. 5 , P. Q05006

Droits : Copyright 2011 by the American Geophysical Union
http://archimer.ifremer.fr/doc/00200/31100/29510.pdf
DOI:10.1029/2010GC003451
http://archimer.ifremer.fr/doc/00200/31100/

Éditeur(s) : Elsevier
Résumé : The Danube Canyon is a large shelf-indenting canyon that has developed seaward of the late Pleistocene paleo-Danube valley. Mechanisms of canyon evolution and factors that controlled it are revealed by analyzing the morphology and the sedimentary structure of the canyon, as well as the main features of the continental margin around the canyon. This is based on investigation by swath bathymetry in the canyon area combined with different types of seismic data. The canyon is a major erosional trough with a flat bottom cut by an entrenched axial thalweg. The thalweg path varies from highly meandering to fairly straight in relation to the local gradient. Segments of the canyon are characterized by specific morphology, orientation and gradient along the axial thalweg. We interpret these segments in terms of canyon maturity. The sedimentary structure of the canyon documents an older phase of erosion followed by partial infilling, and thus attests for repeated cycles of canyon development. Canyon morphology is interpreted as a result of erosive sediment flows along the entrenched axial thalweg that caused downcutting into the canyon bottom and instability of the canyon walls, and hence enlargement of the canyon and expansion by headward erosion. During the last lowstand level of the Black Sea the canyon was located in an area of high sediment supply close to the paleo-Danube River mouths. This is indicated by buried fluvial channels on the shelf and by a wave-cut terrace associated with a water level situated about - 90 m below the present level. We infer that erosive flows in the canyon resulted from hyperpycnal currents at the river mouths, probably favored by the low salinity environment that characterized the Black Sea during lowstand times. Other mechanisms could have contributed to trigger sediment failure along the canyon, such as instability related to the presence of shallow gas, or the effect of a deep fault.
Marine Geology (0025-3227) (Elsevier), 2004-05 , Vol. 206 , N. 1-4 , P. 249-265

Droits : 2004 Elsevier B.V. All rights reserved
http://archimer.ifremer.fr/doc/2004/publication-476.pdf
DOI:10.1016/j.margeo.2004.03.003
http://archimer.ifremer.fr/doc/00000/476/

Éditeur(s) : Pergamon-elsevier Science Ltd
Résumé : Society's needs for a network of in situ ocean observing systems cross many areas of earth and marine science. Here we review the science themes that benefit from data supplied from ocean observatories. Understanding from existing studies is fragmented to the extent that it lacks the coherent long-term monitoring needed to address questions at the scales essential to understand climate change and improve geo-hazard early warning. Data sets from the deep sea are particularly rare with long-term data available from only a few locations worldwide. These science areas have impacts on societal health and well-being and our awareness of ocean function in a shifting climate. Substantial efforts are underway to realise a network of open-ocean observatories around European Seas that will operate over multiple decades. Some systems are already collecting high-resolution data from surface, water column, seafloor, and sub-seafloor sensors linked to shore by satellite or cable connection in real or near-real time, along with samples and other data collected in a delayed mode. We expect that such observatories will contribute to answering major ocean science questions including: How can monitoring of factors such as seismic activity, pore fluid chemistry and pressure, and gas hydrate stability improve seismic, slope failure, and tsunami warning? What aspects of physical oceanography, biogeochemical cycling, and ecosystems will be most sensitive to climatic and anthropogenic change? What are natural versus anthropogenic changes? Most fundamentally, how are marine processes that occur at differing scales related? The development of ocean observatories provides a substantial opportunity for ocean science to evolve in Europe. Here we also describe some basic attributes of network design. Observatory networks provide the means to coordinate and integrate the collection of standardised data capable of bridging measurement scales across a dispersed area in European Seas adding needed certainty to estimates of future oceanic conditions. Observatory data can be analysed along with other data such as those from satellites, drifting floats, autonomous underwater vehicles, model analysis, and the known distribution and abundances of marine fauna in order to address some of the questions posed above. Standardised methods for information management are also becoming established to ensure better accessibility and traceability of these data sets and ultimately to increase their use for societal benefit. The connection of ocean observatory effort into larger frameworks including the Global Earth Observation System of Systems (GEOSS) and the Global Monitoring of Environment and Security (GMES) is integral to its success. It is in a greater integrated framework that the full potential of the component systems will be realised. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
Progress In Oceanography (0079-6611) (Pergamon-elsevier Science Ltd), 2011-10 , Vol. 91 , N. 1 , P. 1-33

Droits : 2011 Published by Elsevier Ltd. All rights reserved.
http://archimer.ifremer.fr/doc/00044/15557/15923.pdf
DOI:10.1016/j.pocean.2011.05.001
http://archimer.ifremer.fr/doc/00044/15557/

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
OBJECTIVES: The aims of the study were to assess in patients with advanced HIV disease receiving antiretroviral therapy (ART) intensification with enfuvirtide (i) resistance at virological failure (VF), (ii) impact of baseline tropism on immunovirological response, and (iii) HIV-1 DNA tropism evolution during ART. METHODS: The ANRS 130 APOLLO randomized trial evaluated in naive patients the immunovirological impact of standard ART without (control arm) or with enfuvirtide. Tropism was determined on RNA and DNA by V3-loop sequencing interpreted using the Geno2Pheno algorithm. RESULTS: At baseline the median CD4 cell count was 30 cells/mm(3). Among the 170 patients assessable in this virological substudy, HIV-1 RNA tropism was as follows: 60% of viruses were R5 and 40% were R5X4/X4. HIV-1 DNA tropism was as follows: 54% were R5 and 46% were R5X4/X4. At week 24, 39% and 49% of patients experienced VF in the enfuvirtide and control arms, respectively. In the enfuvirtide arm, only resistance-associated mutations to enfuvirtide were detected. In the control arm, two patients displayed drug-resistant viruses at the time of VF. No impact of baseline tropism was observed on immunovirological response, regardless of the study arm. Among the 25 patients experiencing DNA tropism switch between baseline and week 24, 16 (64%) switched from R5 to R5X4/X4. These latter were mostly successfully suppressed patients receiving enfuvirtide and exhibiting poorer immunological response. CONCLUSIONS: Baseline RNA tropism had no impact on the immunovirological response. Drug resistance mutations were only detected for the fusion inhibitor. Finally, the mechanism of replenishment of the viral cellular reservoir with X4 viruses observed needs to be further analysed.
ISSN: 0305-7453

hal-00875130
https://hal.archives-ouvertes.fr/hal-00875130
DOI : 10.1093/jac/dks455
PUBMED : 23152480

Éditeur(s) : HAL CCSD Royal Society, The
Résumé : International audience
Many studies have focused on the impacts of climate change on biological assemblages, yet little is known about how climate interacts with other major anthropogenic influences on biodiversity, such as habitat disturbance. Using a unique global database of 1128 local ant assemblages , we examined whether climate mediates the effects of habitat disturbance on assemblage structure at a global scale. Species richness and evenness were associated positively with temperature, and negatively with disturbance. However, the interaction among temperature, precipitation and disturbance shaped species richness and evenness. The effect was manifested through a failure of species richness to increase substantially with temperature in transformed habitats at low precipitation. At low precipitation levels, evenness increased with temperature in undisturbed sites, peaked at medium temperatures in disturbed sites and remained low in transformed sites. In warmer climates with lower rainfall, the effects of increasing disturbance on species richness and evenness were akin to decreases in temperature of up to 98C. Anthropogenic disturbance and ongoing climate change may interact in complicated ways to shape the structure of assemblages, with hot, arid environments likely to be at greatest risk.
ISSN: 0962-8452

hal-01323255
https://hal.archives-ouvertes.fr/hal-01323255
DOI : 10.1098/rspb.2015.0418

Éditeur(s) : Elsevier Sci Ltd
Résumé : The eastern Demerara Plateau offshore French Guiana was surveyed in 2003 during the GUYAPLAC cruise (multibeam bathymetry and acoustic imagery, 6-channel seismic reflection and 3.5 kHz echo-sounding). The data show the "post-transform" Cenozoic that the series located on the outer part of the plateau (below c. 2000 m) contain at least twelve stacked mass transport deposits (MTDs) that have recorded a history of large-scale slope failure, as well as two main normal fault sets that provide possible pathways for upward fluid migration through the series, reaching at high as the uppermost MTDs. Seabed data show that the area above the failures is characterized by circular-to-elongate (slope-parallel) depressions interpreted as fluid seeps (pockmarks), some of them have been modified by along slope currents. We suggest that the development of the MTDs to results from the combinaiton of the presence of fluid overpressure at depth the geometry of the margin's deep structure, in particular the existence of a 'free borderlateral border' on the outermost plateau. Our results also emphasise the role of stratigraphic decollements within the Cenozoic series.
Marine And Petroleum Geology (0264-8172) (Elsevier Sci Ltd), 2013-09 , Vol. 46 , P. 287-303

Droits : 2013 Elsevier Ltd. All rights reserved.
http://archimer.ifremer.fr/doc/00157/26850/25316.pdf
DOI:10.1016/j.marpetgeo.2013.06.010
http://archimer.ifremer.fr/doc/00157/26850/

Éditeur(s) : HAL CCSD Elsevier
Résumé : In this study, we assessed past and present influence of ancient mining activity on metal(loid) enrichment in sediments of a former mining watershed (Gardon River, SE France), that is now industrialized and urbanized. A sedimentary archive and current sediments were characterized combining geochemical analyses, zinc isotopic analyses and sequential extractions. The archive was used to establish local geochemical background and recorded (i) increasing enrichment factors (EFs) for Pb, Zn, Cd, Tl, Hg, As and Sb throughout the industrial era, (ii) a contamination peak in 1976 attributed to a tailings dam failure, and (iii) current levels in 2002 and 2011 similar to those of 1969, except for Sb and Hg, reflecting a persisting contamination pattern. Inter-element relationships and spatial distribution of EF values of current sediments throughout the watershed suggested that both ancient and current contamination had a common origin for Pb, Zn, Cd, Tl and As related to the exploitation of Pb/Zn mineralization while old Sb mines and coal extraction area were the main sources for Sb and Hg respectively. This prevailing mining origin was reflected for Zn by a relatively uniform isotopic composition at δ66Zn = 0.23 ± 0.03‰, although slight decrease from 0.23‰ to 0.18‰ was recorded from upstream to downstream sites along the river course in relation with the contribution of the lighter δ66Zn signature (~ 0.08‰) of acid mine drainage impacted tributaries. Results from sequential extractions revealed that the potential mobility of the studied metal(loid)s varied in the order Sb < Tl ≈ As < Zn < Pb < Cd, with an increase of the mobile pool for Cd, Pb, Zn and to a lesser extent for As and Tl associated to increased enrichment. Altogether, these results tend to demonstrate that ancient mining activity still contributes to metal enrichment in the sediments of the Gardon River and that some of these metals may be mobilized toward the water compartment.
ISSN: 0048-9697

hal-01054163
https://hal.archives-ouvertes.fr/hal-01054163
DOI : 10.1016/j.scitotenv.2014.02.078

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
Background: End-Stage renal disease (ESRD) causes considerable morbidity and mortality, and significantly alterspatients’ quality of life. There are very few published data on this problem in the French Overseas territories. Thedevelopment of a registry on end stage renal disease in French Guiana in 2011 allowed to describe the magnitudeof this problem in the region for the first time.Methods: Using data from the French Renal Epidemiology and Information Network registry (R.E.I.N). Descriptivestatistics on quantitative and qualitative variables in the registry were performed on prevalent cases and incidentcases in 2011, 2012 and 2013.Results: French Guiana has one of the highest ESRD prevalence and incidence in France. The two main causes ofESRD were hypertensive and diabetic nephropathies. The French Guianese population had a different demographicprofile (younger, more women, more migrants) than in mainland France. Most patients had at least one comorbidity,predominantly (95.3%) hypertension. In French Guiana dialysis was initiated in emergency for 71.3% of patients versus33% in France (p < 0.001).Conclusion: These first results give important public health information: i) End stage renal disease has a very highprevalence relative to mainland France ii) Patients have a different demographic profile and enter care late in thecourse of their renal disease. These data are closer to what is observed in the Caribbean or in Latin America than inMainland France.
ISSN: 1471-2369

inserm-01567222
http://www.hal.inserm.fr/inserm-01567222
http://www.hal.inserm.fr/inserm-01567222/document
http://www.hal.inserm.fr/inserm-01567222/file/2017%2C%20Rochemont%20-%20End%20stage%20renal%20disease.pdf
DOI : 10.1186/s12882-017-0614-6

Éditeur(s) : HAL CCSD Thieme Publishing
Résumé : International audience
The aim of the present study was to compare the effects of prior cycling and a successive run on respiratory muscle performance during a cycle-run succession as performed in the triathlon. We hypothesized that despite the moderate intensity of exercise and the absence of exhaustion, the crouched cycling position would induce a decrease in respiratory muscle performance that would be reversed by the successive vertical run position. Ten male triathletes (22.6 +/- 1.1 yr) performed a four-trial protocol: (1) an incremental cycle test to assess maximal oxygen uptake (VO2max), (2) 20 min of cycling (C), (3) 20 min of running (R), and (4) 20 min of cycling followed by 20 min of running (C-R). Trials 2, 3 and 4 were performed at the same metabolic intensity, i. e., 75 % of VO2max. Respiratory muscle force was assessed by measuring maximal expiratory (P(Emax)) and inspiratory (P(Imax)) pressures from the functional residual capacity (FRC) before and 10 min after C, R, and C-R. Respiratory muscle endurance was assessed one day before and 30 min after C, R, and C-R, by measuring the time limit (T(lim)), which corresponds to the length of time a respiratory load can be sustained before the process of fatigue develops sufficiently to cause task failure. The results showed a similar significant decrease in P(Imax) (132.4 +/- 4.9 versus 125.7 +/- 5.6 cm H2O, p < 0.05) and T(lim) (5.22 +/- 0.28 versus 3.68 +/- 0.32 min, p < 0.05) post-C and post-C-R (133.7 +/- 4.0 versus 126.9 +/- 5.2 cm H2O, and 5.29 +/- 0.18 versus 3.49 +/- 0.41 min, respectively, p < 0.05) compared with the pre-trial values. In contrast, P(Imax) and T(lim) were not significantly decreased post-R (131.8 +/- 6.1 cm H2O versus 129.6 +/- 6.4 cm H2O, and 4.90 +/- 0.69 versus 4.40 +/- 0.56 min, respectively, p > 0.05). We concluded that moderate intensity exercise not performed to exhaustion induced a decrease in respiratory muscle performance. Moreover, the respiratory muscle fatigue induced by prior cycling was maintained, and neither reversed nor worsened, by the successive run.
ISSN: 0172-4622

hal-00720715
https://hal.univ-antilles.fr/hal-00720715

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
RATIONALE: Optimal management of complicated parapneumonic effusions (CPPE) remains controversial. OBJECTIVES: to assess safety and efficacy of iterative therapeutic thoracentesis (ITTC), the first-line treatment of CPPE in Rennes University Hospital. METHODS: Patients with CPPE were identified through our computerized database. We retrospectively studied all cases of CPPE initially managed with ITTC in our institution between 2001 and 2010. ITTC failure was defined by the need for additional treatment (i.e. surgery or percutaneous drainage), or death. RESULTS: Seventy-nine consecutive patients were included. The success rate was 81% (n = 64). Only 3 patients (4%) were referred to thoracic surgery. The one-year survival rate was 88%. On multivariate analysis, microorganisms observed in pleural fluid after Gram staining and first thoracentesis volume ≥450 mL were associated with ITTC failure with adjusted odds-ratios of 7.65 [95% CI, 1.44-40.67] and 6.97 [95% CI, 1.86-26.07], respectively. The main complications of ITTC were iatrogenic pneumothorax (n = 5, 6%) and vasovagal reactions (n = 3, 4%). None of the pneumothoraces required chest tube drainage, and no hemothorax or re-expansion pulmonary edema was observed. CONCLUSIONS: Although not indicated in international recommendations, ITTC is safe and effective as first-line treatment of CPPE, with limited invasiveness.
ISSN: 1932-6203

hal-00945622
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00945622
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00945622/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00945622/file/fetchObject.pdf
PUBMED : 24400113

Éditeur(s) : HAL CCSD BMJ Publishing Group
Résumé : International audience
We read with interest the report by Desrosiers et al 1 on the association between maternal occupational exposure to organic solvents and some birth defects. Their case-control study examined occupational exposure to three classes of solvents (chlorinated, aromatic and Stoddard) and found one association--between neural tube defects (mainly spinal bifida) and maternal occupational exposure to chlorinated solvents, but no association with the other solvent classes or with oral clefts. In their discussion, the authors noted that previous findings on maternal occupational exposure to solvents and oral clefts were from European, mainly French, populations and they hypothesised that the inconsistency between their results and these previous studies might be due to different exposure profiles (eg, intensity and solvent formulation). Although this explanation is plausible, another explanation must be discussed: differences in the definition of exposure. Our research team conducted four of the five studies with positive results cited by Desrosiers et al.2-5 All four were population based and included, in addition to the solvent classes considered by Desrosiers et al, oxygenated solvents, for example, alcohols or glycol ethers. Exposure limited to only oxygenated solvents appears to be very frequent among working women: more than half of the solvent exposure group in Chevrier et al 4 were exposed only to that solvent class. Because previous studies found an increased risk of oral clefts to be associated principally with that specific exposure, failure to consider this association could explain the negative findings for oral clefts. Moreover, women who were exposed only to oxygenated solvents are included in the reference ('non-exposed') group here, which would result in underestimating associations with chlorinated and petroleum solvents. For both these reasons, we believe that the failure to consider oxygenated solvents led to underestimating the risk estimates for oral clefts.
ISSN: 1351-0711

hal-00875943
https://hal.archives-ouvertes.fr/hal-00875943
DOI : 10.1136/oemed-2012-100999
PUBMED : 22843438

Éditeur(s) : HAL CCSD Wiley-Blackwell
Résumé : International audience
Despite convergent margins being unstable systems, most reports of huge submarine slope failure have come from oceanic volcanoes and passive margins. Swath bathymetry and seismic profiles of the northern Hikurangi subduction system, New Zealand, show a tapering 65-30 km wide by 65 km deep margin indentation, with a giant, 3150+_630 km 3, blocky, debris avalanche deposit projecting 40 km out across horizontal trench fill, and a debris flow deposit projecting over 100 km. Slide blocks are well-bedded, up to 18 km across and 1.2 km high, the largest being at the avalanche deposit's leading edge. Samples dredged from them are mainly Miocene shelf calc-mudstones similar to those outcropping around the indentation. Cores from cover beds suggest that failure occurred-170 +_40 ka, possibly synchronously with a major extension collapse in the upper indentation. However, the northern part of the indentation is much older. The steep, straight northern wall is close to the direction of plate convergence and probably formed around 2.0-0.16 Ma as a large seamount subducted, leaving in its wake a deep groove obliquely across the margin and an unstable triangle of fractured rock in the 60 ø angle between groove and oversteepened margin front. The triangle collapsed as a blocky avalanche, leaving a scalloped southern wall and probably causing a large tsunami. Tentative calculations of compacted volumes suggest that the indentation is over 600 km 3 larger than the avalanche, supporting a two-stage origin that includes subduction erosion. Since failure, convergence has carried the deposits-9 km back toward the margin, causing internal compression. The eventual subduction/accretion of the Ruatoria avalanche explains the scarcity of such features on active margins and perhaps the nature of olistostromes in fold belts.
ISSN: 2169-9275

hal-01261406
https://hal.archives-ouvertes.fr/hal-01261406
https://hal.archives-ouvertes.fr/hal-01261406/document
https://hal.archives-ouvertes.fr/hal-01261406/file/CollotJGR2001.pdf
DOI : 10.1029/2001JB900004

Éditeur(s) : HAL CCSD AGU and the Geochemical Society
Résumé : International audience
The 2004 Aceh and 2005 Nias events are the two greatest earthquakes of the past 40 years with a total rupture of 1700 km long and a coseismic slip reaching up to 25 m. These two earthquakes have caused large stress perturbations which significantly altered seismic activity in the Sumatra-Andaman region. Using both detailed mapping of failure planes and various slip distributions, we calculate this stress change along the Sumatra-Andaman-Sagaing fault system from central Sumatra to southern Myanmar. The static Coulomb stress change Delta CFF and the observed seismic activity are in very good agreement with a Coulomb index similar to 20% greater than the one obtained for random events. Compared to previous studies, this high Coulomb Index confirms two important issues on the use of static stress change criterion: unsuited to study near-field aftershocks and only relevant for aftershocks analysis on large and mature faults at a time scale of several months. The calculated Delta CFF distribution suggests that the 2004 and 2005 earthquakes inhibit failure on the North Andaman rift and on the Sagaing fault, while failure is encouraged along the transform Andaman zone, the central Andaman rift, the West Andaman fault, the Sumatra fault system, and the offshore thrust faults west of Sumatra Island. The maximum value of similar to 15-20 bar (1.5-2 MPa) for Delta CFF is reached in the northern part of the Sumatra fault system. This high value together with the lack of major earthquake in the last 170 years result in a high seismic hazard for this region. Our results are also consistent with temporal evolution of both earthquakes' location and focal mechanism prior to and after the events. In particular, we explain the occurrence and the mechanism of seismic swarms observed in the central Andaman rift and along the west Andaman fault. Finally, our calculations reveal that the seismicity in the Andaman rift zone can only be explained if mu' > 0.5. This result leads to two end-member models: one with a constant and high fault friction and one with spatial variations, for which friction may depend on either the nature of the lithosphere (oceanic versus continental) or the fault type.
ISSN: 1525-2027

hal-00456027
https://hal.archives-ouvertes.fr/hal-00456027
DOI : 10.1029/2008GC002167

Éditeur(s) : HAL CCSD
Résumé : National audience
In severe male infertility, in vitro fertilization (IVF) with intra-cytoplasmic sperm injection (ICSI) represents the sole available therapeutic option. However this technique is not always successful in promoting fertilization, as some couples completely and repeatedly fail to obtain any embryo. In many cases, this failure can be attributed to a defective rise in intracellular calcium, which is required to achieve oocyte activation. Over the last twenty years, several laboratories dedicated to assisted reproduction technologies have been using a calcium ionophore to assist oocyte activation. The aim of this review is to give an overview of the advances and consequences associated with this new technique referred to as assisted oocyte activation
Médecine Sciences: M/S

hal-01286256
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01286256
DOI : 10.1051/medsci/20163202014
PUBMED : 26936178

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Background: Influenza is an important cause of serious illness and death, particularly in elderly and high-risk groups. Objectives Aim of this study was to identify factors associated with poor outcomes among adults hospitalized in France for laboratory-confirmed seasonal influenza. Study design Patients hospitalized for influenza were identified in a prospective, multicenter study carried out in French hospitals during three consecutive influenza seasons (2012–2015). Influenza virus infection was confirmed by reverse transcription polymerase chain reaction. Sociodemographic and clinical variables were compared according to the virus type and subtype. Risk factors for complications, intensive care unit (ICU) admission and death were analyzed by backward stepwise logistic regression. Results The study population consisted of 566 patients, of whom 56% were older than 65 years and 82% had underlying chronic illnesses. Type A influenza viruses infected 422 patients (75%), including subtype H3N2 in 239 patients (57%). The prior vaccine coverage rate was 38%. Complications occurred in 255 patients (45%), consisting mainly of pneumonia (n = 143, 30%) and respiratory failure (n = 116, 20%). Eighty-three patients (15%) were admitted to an ICU, and the in-hospital mortality rate was 4% (n = 21). Sixty-six patients (12%) received oseltamivir. Age over 65 years was the only identified risk factor for complications. Risk factors for ICU admission were an absence of vaccination, no oseltamivir administration before admission, pre-existing chronic respiratory disease, and current smoking. Age over 65 years and ICU admission were risk factors for death. Conclusions Older individuals and patients with underlying conditions are most at risk of influenza complications. Vaccination and early oseltamivir administration, both of which are recommended for these patients, appear to reduce ICU admissions
ISSN: 1386-6532

hal-01302409
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01302409
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01302409/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01302409/file/Factors%20associated%20with%20poor%20outcomes.pdf
DOI : 10.1016/j.jcv.2016.04.005

Éditeur(s) : Pêche thonière et dispositifs de concentration de poissons, Caribbean-Martinique, 15-19 Oct 1999 15-19 octobre 1999
Résumé : The development of the FAD gave rise to technical problems owing to their conception, their setting spot and of their utilisation. Failings generated by the unreliability of components or the uncertain repair precariousness, those can prove to be here more and more expensive with the progression of the ageing of devices and reasons of their loss. For as various domains that aerospace or the fishing deck layout, the engineering has functional analysis tools that permit to reduce conception uncertainties of systems by the mean of a hierarchical classification of function values of components. The application of one of these techniques, the FMEA, Failure Mode and Effects Analysis, to the study of reasons of FAD loss in La Reunion describes perfectly everything that this type of method can bring to the appraisal in fishing technology. This preventive analysis method assess the potential risks integrates perfectly in the mind of a precaution approach as it would agree to see to apply to the FADs and to their exploitation.Original Abstract: Le developpement des DCP a entraine l'apparition de problemes techniques, issus tant de leur conception, de leur lieu d'implantation que de leur utilisation. Defaillances generees par le manque de fiabilite des composants ou la precarite de reparations aleatoires, celles-ci peuvent s'averer de plus en plus couteuses au fur et a mesure du vieillissement des systemes et cause a terme de leur perte. Pour des domaines aussi divers que l'aerospatiale ou l'amenagement de pont de peche, l'ingenierie dispose d'outils d'analyse fonctionnelle qui, par le biais d'une hierarchisation des valeurs des fonctions de chaque element des systemes etudies, permettent de reduire les incertitudes de la conception. L'application d'une de ces techniques, l'Amdec, analyse des modes de defaillance et de criticite, a l'etude des causes des pertes de DCP a La Reunion illustre parfaitement tout ce que ce type de methode peut apporter a l'expertise en technologie des peches. Cette methode d'analyse preventive qui recense et met en evidence les risques potentiels s'integre parfaitement dans l'esprit d'une approche de precaution telle que celle qu'il conviendrait de voir appliquer aux DCP et a leur exploitation.

Droits : Ifremer
http://archimer.ifremer.fr/doc/00042/15289/12675.pdf
http://archimer.ifremer.fr/doc/00042/15289/

Éditeur(s) : Amer Geophysical Union
Résumé : On November 21, 2004, a magnitude 6.3 earthquake occurred offshore, 10 km south of Les Saintes archipelago in Guadeloupe (French West Indies). There were more than 30000 aftershocks recorded in the following two years, most of them at shallow depth near the islands of the archipelago. The main shock and its main aftershock of February 14, 2005 (M-w = 5.8) ruptured a NE-dipping normal fault (Roseau fault), mapped and identified as active from high-resolution bathymetric data a few years before. This fault belongs to an arc-parallel en echelon fault system that follows the inner edge of the northern part of the Lesser Antilles arc, accommodating the sinistral component of oblique convergence between the North American and Caribbean plates. The distribution of aftershocks and damage (destruction and landslides) are consistent with the main fault plane location and attitude. The slip model of the main shock, obtained by inverting jointly global broadband and local strong motion records, is characterized by two main slip zones located 5 to 10 km to the SE and NW of the hypocenter. The main shock is shown to have increased the Coulomb stress at the tips of the ruptured plane by more than 4 bars where most of the aftershocks occurred, implying that failures on fault system were mainly promoted by static stress changes. The earthquake also had an effect on volcanic activity since the Boiling Lake in Dominica drained twice, probably as a result of the extensional strain induced by the earthquake and its main aftershock.
Journal Of Geophysical Research-solid Earth (0148-0227) (Amer Geophysical Union), 2011-10 , Vol. 116 , N. B10301 , P. 1-25

Droits : Copyright 2011 by the American Geophysical Union.
http://archimer.ifremer.fr/doc/00200/31099/29511.pdf
DOI:10.1029/2011JB008310
http://archimer.ifremer.fr/doc/00200/31099/

Éditeur(s) : Springer
Résumé : The Var turbidite system is a small sandy system located in the Ligurian Basin. It was deposited during the Pliocene-Quaternary in a flat-floored basin formed during the Messinian salinity crisis. The system was fed through time by the Var and Paillon canyons that connect directly to the Var and Paillon rivers. It is still active during the present sea-level highstand. Two main mechanisms are responsible for gravity-flow triggering in the Var turbidite system: (1) mass-wasting events affect mainly the upper part of the continental slope, in areas where volumes of fresh sediment delivered by rivers are highest, and result from the under-consolidation state of slope sediments and earthquakes, and (2) high-magnitude river floods resulting from melting of snow and convective rainfall during fall and spring seasons, and generating hyperpycnal turbidity currents at river mouths when the density of freshwater transporting suspended particles exceeds that of ambient seawater. Failure- and flood-induced gravity flows are involved through time in the construction of the Var Sedimentary Ridge, the prominent right-hand levee of the Var system, and sediment waves. Processes of construction of both the Var Ridge and sediment waves are closely connected. Sandy deposits are thick and abundant in the eastern (downchannel) part of the ridge. Their distribution is highly constrained by the strong difference of depositional processes across the sediment waves, potentially resulting through time in the individualization of large and interconnected sand bodies.
Geo-Marine Letters (0276-0460) (Springer), 2006-12 , Vol. 26 , N. 6 , P. 361-371

Droits : 2006 Springer
http://archimer.ifremer.fr/doc/2006/publication-2258.pdf
DOI:10.1007/s00367-006-0047-x
http://archimer.ifremer.fr/doc/00000/2258/