Éditeur(s) : HAL CCSD
Résumé : International audience
In French Guiana, the prevalence of HIV among pregnant women along the Maroni river, has risen from 0 to over 1% in the 1990's. Despite this sharp increase, no behavioural surveillance study has ever taken place in this border region. The present study showed that an important proportion of boatmen have risky sexual behaviour. These results underline the importance of targeting prevention interventions on this population that is not currently receiving specific HIV prevention messages.
J AIDS Clinic Res

Droits : info:eu-repo/semantics/OpenAccess
inserm-00915224
http://www.hal.inserm.fr/inserm-00915224
http://www.hal.inserm.fr/inserm-00915224/document
http://www.hal.inserm.fr/inserm-00915224/file/2012_Gaubert_-_KABP_on_HIV_among_Boatmen_on_the_Maroni_river_a_neglected_bridging_group.pdf
DOI : 10.4172/2155-6113.1000181

Éditeur(s) : HAL CCSD
Résumé : International audience
Aim The global increase in the rate of cesarean sections (CS) is currently an issue. We aimed to assess the rate of CS locally and to identify cases in which this procedure may have been avoidable. Methods In this prospective consecutive series, we analyzed the 478 CS carried out in our unit in 2009. We analyzed the characteristics of each case, and classified each as potentially avoidable or unavoidable. Results The total rate of CS was 24.0%, including 1.7% that was scored as potentially avoidable. Parity, gestational age at birth, birthweight, cases requiring cervical ripening, cases of labor induction, and CS during labor were all significantly higher or more frequent among potentially avoidable CS. Multivariate analysis indicated that the risk of potentially avoidable CS was positively associated with gestational age and tended to be negatively associated with parity. The main indications for potentially avoidable CS were cervical dystocia and abnormal fetal heart rate, and for unavoidable CS they were abnormal fetal heart rate and history of previous CS. Conclusion Labor, especially when induced, seems to be the key period for the prevention of ‘avoidable’ CS. This is particularly important given that potentially avoidable CS are more frequently associated with uncomplicated pregnancies than are unavoidable CS. A woman's first CS increases the likelihood of CS for subsequent deliveries, so the prevention of the first CS is a key aim for reducing the overall rate of CS
Journal of Obstetrics and Gynaecology Research

hal-01305484
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01305484
PUBMED : 27094021
DOI : 10.1111/jog.13007

Éditeur(s) : Pêche thonière et dispositifs de concentration de poissons, Caribbean-Martinique, 15-19 Oct 1999 15-19 octobre 1999
Résumé : The development of the FAD gave rise to technical problems owing to their conception, their setting spot and of their utilisation. Failings generated by the unreliability of components or the uncertain repair precariousness, those can prove to be here more and more expensive with the progression of the ageing of devices and reasons of their loss. For as various domains that aerospace or the fishing deck layout, the engineering has functional analysis tools that permit to reduce conception uncertainties of systems by the mean of a hierarchical classification of function values of components. The application of one of these techniques, the FMEA, Failure Mode and Effects Analysis, to the study of reasons of FAD loss in La Reunion describes perfectly everything that this type of method can bring to the appraisal in fishing technology. This preventive analysis method assess the potential risks integrates perfectly in the mind of a precaution approach as it would agree to see to apply to the FADs and to their exploitation.Original Abstract: Le developpement des DCP a entraine l'apparition de problemes techniques, issus tant de leur conception, de leur lieu d'implantation que de leur utilisation. Defaillances generees par le manque de fiabilite des composants ou la precarite de reparations aleatoires, celles-ci peuvent s'averer de plus en plus couteuses au fur et a mesure du vieillissement des systemes et cause a terme de leur perte. Pour des domaines aussi divers que l'aerospatiale ou l'amenagement de pont de peche, l'ingenierie dispose d'outils d'analyse fonctionnelle qui, par le biais d'une hierarchisation des valeurs des fonctions de chaque element des systemes etudies, permettent de reduire les incertitudes de la conception. L'application d'une de ces techniques, l'Amdec, analyse des modes de defaillance et de criticite, a l'etude des causes des pertes de DCP a La Reunion illustre parfaitement tout ce que ce type de methode peut apporter a l'expertise en technologie des peches. Cette methode d'analyse preventive qui recense et met en evidence les risques potentiels s'integre parfaitement dans l'esprit d'une approche de precaution telle que celle qu'il conviendrait de voir appliquer aux DCP et a leur exploitation.

Droits : Ifremer
http://archimer.ifremer.fr/doc/00042/15289/12675.pdf
http://archimer.ifremer.fr/doc/00042/15289/

Éditeur(s) : HAL CCSD American Diabetes Association
Résumé : International audience
OBJECTIVE: To compare incidences and risk factors for diabetes using seven definitions, with combinations of pharmacological treatment, fasting plasma glucose (FPG) ≥7.0 mmol/L, and HbA(1c) ≥6.5%. RESEARCH DESIGN AND METHODS: Participants aged 30-65 years from the Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) cohort were followed for 9 years. RESULTS: More men had incident diabetes as defined by FPG ≥7.0 mmol/L and/or treatment than by HbA(1c) ≥6.5% and/or treatment: 7.5% (140/1,867) and 5.3% (99/1,874), respectively (P < 0.009); for women incidences were similar: 3.2% (63/1,958) and 3.4% (66/1,954). Known risk factors predicted diabetes for almost all definitions. Among those with incident diabetes by FPG alone versus HbA(1c) alone, there were more men (78 vs. 35%), case patients were 8 years younger, and fewer were alcohol abstainers (12 vs. 35%) (all P < 0.005). A diabetes risk score discriminated well between those with and without incident diabetes for all definitions. CONCLUSIONS: In men, FPG definitions yielded more incident cases of diabetes than HbA(1c) definitions, in contrast with women. An FPG-derived risk score remained relevant for HbA(1c)-defined diabetes.
Diabetes Care

inserm-00739799
http://www.hal.inserm.fr/inserm-00739799
http://www.hal.inserm.fr/inserm-00739799/document
DOI : 10.2337/dc10-1581
PUBMED : 21346181

Résumé : By looking at the common thread between 4 programs* in which the IFREMER Palavas (34, Languedoc-Roussillon region in France) station took part, this report show the evolution over 20 years in the perception of the pathology of farmed fish, and of the sea bass in particular (Dicentrarchus labrax). During the 1990’s farming techniques became sufficiently reliable to enable to distinguish between problems of a zootechnical nature and those with a pathological origin. In anticipation of future illnesses, the necessary tools and monitoring were implemented in order to study the immune system of the sea bass. These methods arose from the recent creation of anti-immunoglobin monoclonal probes in the sea bass. These techniques, together with others, served to search for a solution to the nodavirus epidemic which struck in1996. In the absence of a cure for this virus, the research focused on knowledge of the virus, its epidemiology and vaccine development. Despite interesting scientific results, the solution withheld to curb the Nodavirus epidemic was zootechnical. This pragmatic outcome catalysed reflections on the role of pathology, leading to notions of health, animal well-being and image. Management choices in the health of farmed fish stocks became a parameter, amongst others, included in a global commercial and farming policy. * Définition des critères d’évaluation de l’immunocompétente chez le loup et le turbot. UMR1 Université Montpellier II IFREMER ; Nodavirus disease of cultured marine fish in Europe. FAIR PL98 4036 EU; Recherche de moyens de dépistage et prévention de la nodavirose du bar. ANVAR 9804041J ; Welfare and Health in Sustainable Aquaculture WEALTH. E.U N°501984.
En prenant comme fil conducteur les travaux de 4 programmes* auxquels a participé la station IFREMER de Palavas (34), ce rapport montre l’évolution sur 20 ans de la perception de la pathologie des poissons d’élevages et du loup en particulier (Dicentrarchus labrax). Dans les années 1990 les techniques d’élevages devinrent suffisamment fiables pour permettre de distinguer les problèmes d’origines zootechniques de ceux d’origines pathologiques. En prévision des futures maladies potentielles, les outils d’étude et de suivi du système immunitaire spécifique du loup furent mis en place. Ils découlaient de la création récente de sondes monoclonales anti-immunoglobulines de loup. Ces techniques, couplées à d’autres, servirent à chercher une solution à l’épidémie de nodavirose des années 1996. En l’absence de traitement pour un virus l’accent fut mis sur la connaissance du virus, de son épidémiologie et de la vaccination. Bien que les résultats scientifiques furent très satisfaisants la solution trouvée pour juguler l’épidémie de Nodavirose fut zootechnique. Cette issue pragmatique catalysa une réflexion sur le rôle de la pathologie qui maturait depuis plusieurs années et qui déboucha sur la notion de santé, de bien être des animaux et d’image. Les choix de gestion de la santé des cheptels devinrent un paramètre, parmi d’autres, s’incluant dans d’une politique globale d’élevage et commerciale * Définition des critères d’évaluation de l’immunocompétente chez le loup et le turbot. UMR1 Université Montpellier II IFREMER ; Nodavirus disease of cultured marine fish in Europe. FAIR PL98 4036 EU; Recherche de moyens de dépistage et prévention de la nodavirose du bar. ANVAR 9804041J ; Welfare and Health in Sustainable Aquaculture WEALTH. E.U N°501984.

Droits : 2013 Ifremer
http://archimer.ifremer.fr/doc/00167/27866/26103.pdf
http://archimer.ifremer.fr/doc/00167/27866/26105.pdf
http://archimer.ifremer.fr/doc/00167/27866/26106.pdf
http://archimer.ifremer.fr/doc/00167/27866/

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : Cet article souligne la particularité des politiques locales menées récemment en Martinique et en Guadeloupe en matière de gestion du risque sismique. Ces Départements français des Amériques, fortement exposés à la menace sismique, s’impliquent depuis peu dans une véritable dynamique préventive soutenue par l’action des Collectivités. Des stratégies locales de réduction de la vulnérabilité humaine et technique sont expérimentées au bénéfice de la population. Elles viennent renforcer ou compléter les efforts étatiques visant une plus grande implication du citoyen à son information et à sa sécurité face aux séismes.
This article underlines the characteristic of the local policies followed recently in Martinique and Guadeloupe as regards seismic risk management. These French Departments of Americas, strongly exposed to the seismic threat, imply themselves recently in a true preventive dynamics supported by the action of the Communities. Local strategies of reduction of the human and technical vulnerability are tested for the benefit of the population. They come to reinforce or supplement the official efforts of French State aiming a greater implication of the citizen to his information and its safety against the earthquakes.
Guadeloupe
Martinique

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.289
http://journals.openedition.org/etudescaribeennes/289

Éditeur(s) : HAL CCSD Association des Géographes Français
Résumé : International audience
Cet article résume les résultats des tables rondes et de 41 contributions de chercheurs français et étrangers au colloque international « Croissance urbaine et risques naturels» qui s'est déroulé à l'Université Blaise-Pascal, Clermont-Ferrand, les 2 et 3 décembre 1994.L'objectif général du colloque était de rassembler les diverses compétences existant en France et à l'étranger dans le domaine de l'évaluation et de la gestion des risques naturels et de confronter les expériences acquises à l'interface entre les villes en croissance et le champ d'action des phénomènes naturels créateurs de risques. Le colloque a donc réuni des chercheurs, des doctorants et des praticiens de 12 pays, chargés de prévention, de gestion des risques naturels et de gestion urbaine, principalement dans les grandes villes des pays en développement.Les contributions ont été regroupées, exposées et discutées lors du colloque sous forme de 3 thèmes : (1) Les phénomènes naturels créateurs de dommages (= menaces) : diagnostic, inventaire et typologie, (2) Les vulnérabilités des sociétés et des espaces urbanisés : concepts, typologie et modes d'analyse, (3) Les outils d'aide à la prévention et à la gestion du risque en milieu urbain.
ISSN: 0004-5322

hal-01165458
https://hal.archives-ouvertes.fr/hal-01165458
https://hal.archives-ouvertes.fr/hal-01165458/document
https://hal.archives-ouvertes.fr/hal-01165458/file/article_bagf_0004-5322_1995numéro 72_4_1843.pdf

Éditeur(s) : Société Française de Chimie
Résumé : The coastal marine environment presents some specificity compared to other aquatic environments: it is both the receiving end of pollution on land and the most biologically rich marine area, where are developing many uses (fisheries and aquaculture, salt production, tourism, thalassotherapy). The coastal zone is therefore vulnerable to chronic chemical pollution and its protection requires research, monitoring and regulation. A dual strategy can be put into place: a preventive approach to avoid placing on the market of toxic substances to humans and the environment, and a retrospective approach based on public policies for the protection and restoration of degraded aquatic environments.
Le milieu marin côtier présente une certaine spécificité par rapport aux autresmilieux aquatiques : il est à la fois le milieu récepteur ultime des pollutions terrestres et la zone la plus riche biologiquement, et le milieu où se développent de nombreuses activités (pêche et cultures marines, saliculture, tourisme, thalassothérapie). La zone côtière littorale est par conséquent vulnérable aux pollutions chimiques chroniques et sa protection nécessite recherche, surveillance et réglementation. Une double stratégie peut être mise en place : une approche préventive pour éviter la mise sur le marché de substances toxiques pour l'Homme et l'environnement, et une approche rétrospective basée sur des politiques publiques pour la protection et la restauration des milieux aquatiques dégradés.
Actualité chimique (0151-9093) (Société Française de Chimie), 2008-12 , N. 325 , P. 35-40

Droits : 2008 Société Française de Chimie
http://archimer.ifremer.fr/doc/2008/publication-6374.pdf
http://archimer.ifremer.fr/doc/00000/6374/

Éditeur(s) : Elsevier
Résumé : Beach sediment cementation (beachrock formation) is a sedimentary process that can transform significant sections of beaches into rock outcrops. This contribution reports the results of two questionnaire surveys (one focusing on foreign tourists and the other on local people) carried out in coastal resorts of the island of Lesbos (Greece), on the perceptions of beach users regarding the impacts of beachrocks on their recreational activities. The survey focusing on foreign tourists showed that the majority of the interviewees took notice of the formations and commented negatively on them. Although most of the interviewees did not consider beachrocks a significant safety risk, a considerable proportion of the sample stated that beachrocks influenced their beach ratings that they would prefer beachrock-free beaches and would be willing to contribute financially to preventative and protective measures. In contrast, the results of the survey focusing on local people, who are more familiar with the phenomenon, showed a high perception of beachrock-related risks and limited beachrock tolerance. In addition to the safety risks that the irregular, slippery, beachrock surfaces may pose to beach users, beachrocks may also degrade beach aesthetics. promote beach sediment erosion and decrease the beach carrying capacity. As beachrocks are a common attribute of tropical, subtropical and low-temperate beaches that are typically associated with major tourist destinations, and are likely to spread under global warming conditions, they may be considered as a significant threat to the coastal tourist industry. (c) 2008 Elsevier Ltd. All rights reserved.
Tourism Management (0261-5177) (Elsevier), 2009-08 , Vol. 30 , N. 4 , P. 544-552

Droits : 2009 Elsevier Ltd All rights reserved.
http://archimer.ifremer.fr/doc/2009/publication-6625.pdf
DOI:10.1016/j.tourman.2008.09.007
http://archimer.ifremer.fr/doc/00000/6625/

Éditeur(s) : HAL CCSD Taylor & Francis (Routledge)
Résumé : International audience
The French Antilles (Martinique, Saint Martin and Guadeloupe) and French Guiana are the French territories most affected by the HIV epidemic. Some population groups such as men who have sex with men (MSM), especially those involved in transactional sex, are thought to be particularly vulnerable to HIV but few data exist to help characterize their health-related needs and thus implement relevant prevention interventions. To fill this knowledge gap, we used data collected from an HIV/AIDS Knowledge, Attitudes, Behaviours and Practices survey conducted in 2012 among MSM living in the French Antilles and French Guiana and recruited through snowball sampling. Our objectives were to compare social and demographic characteristics and sexual behaviours between MSM engaging in transactional sex and MSM not engaging in transactional sex and to identify factors associated with transactional sex involvement using a logistic regression model. A total of 733 MSM were interviewed, 21% of whom reported to undergo transactional sex. Their behaviour and social and demographic characteristics were different from other MSMs’ and they were more exposed to factors that are recognized to potentiate HIVvulnerability, at the individual, community, network and structural levels. The variables positively associated with sex trade involvement were having ever consumed drug (OR = 2.84 [1.23–6.52]; p = .002), having a greater number of sex partners than the median (OR = 8.31 [4.84–14.30]; p < .001), having experienced intimate partner violence (OR = 1.72 [0.99–3.00]; p = .053) and having undergone physical aggression because of sexual orientation (OR = 2.84 [1.23–6.52];p = .014). Variables negatively associated with sex trade involvement were being older (OR = 0.93 [0.90–0.97] per year; p = .001), having a stable administrative situation (OR = 0.10 [0.06–0.19]; p < .001), having a stable housing (OR = 0.29 [0.15–0.55]; p < .001) and being employed full-time (OR = 0.29 [1.23–6.52]; p = .002).
ISSN: 0954-0121

inserm-01407263
http://www.hal.inserm.fr/inserm-01407263
http://www.hal.inserm.fr/inserm-01407263/document
http://www.hal.inserm.fr/inserm-01407263/file/AIDS%20Care%20final%20version.pdf
DOI : 10.1080/09540121.2016.1234680

Éditeur(s) : HAL CCSD
Résumé : International audience
La santé est une préoccupation mondiale et grandissante occupant une place prépondérante aussi bien dans les débats de la sphère publique que dans les conversations ordinaires. Toutefois, la vie numérique de l’usager est encore mal connue, ainsi que les ressorts des représentations qui régissent les comportements dans ce domaine. C’est donc à partir de la théorie des représentations sociales que nous proposons d’appréhender la e-médecine en tant que phénomène de société. La e-santé consécutive à l’essor du numérique et des technologies mobiles autorise non seulement la consommation de connaissances liées à la santé, mais également la production et diffusion de celles-ci. Aussi, dans le domaine de la médecine, le recours aux outils numériques a initié de nombreuses ruptures comportementales et entraîné de fait la création d’un univers représentationnel associé qui favorise ou non leur acceptabilité par les utilisateurs potentiels.
Les écosystèmes numériques et la démocratisation informationnelle : Intelligence collective, Développement durable, Interculturalité, Transfert de connaissances
Schoelcher, France

hal-01265735
https://hal.univ-antilles.fr/hal-01265735
https://hal.univ-antilles.fr/hal-01265735/document
https://hal.univ-antilles.fr/hal-01265735/file/Lucile%20SALESSES%20et%20al.pdf

Éditeur(s) : HAL CCSD Association de Géographes Français
Résumé : International audience
The international symposium on Urban Growth and Natural Hazards, in particular in Developing Countries was held in the Université Blaise-Pascal, Clermont-Ferrand (France) on December 2 and 3, 1994. This meeting brought together about 70 researchers, Ph. D. students, and professionals from France and 12 other countries, representing universities, research agencies, as well as government and private companies. The symposium aimed to gather specialists who are engaged and acting in programmes on hazard appraisal, risk prevention and urban management in the city environment. These people compared experiences acquired in two different fields: on the one hand urban growth and its consequences, and on the other hand, natural hazards and their effects, in particular in developing countries.From the 41 contributions given at the symposium, 4 papers were selected by the editorial board of this Bulletin de l'Association de Géographes Français for this special issue, which includes three chapters corresponding to the three sessions of the symposium: (1) Natural hazards and environmental factors : inventory, diagnostic and classification, (2) Vulnerability of urban society and environment : concepts, approaches, and classification, (3) Tools for urban risk prevention and risk management in case of crisis and catastrophes.
Ce numéro du Bulletin de l'Association de Géographes Français résume les résultats des tables rondes et de 41 contributions de chercheurs français et étrangers au colloque international «Croissance urbaine et risques naturels dans les pays en développement» qui s'est déroulé à l'Université Blaise-Pascal, Clermont-Ferrand, les 2 et 3 décembre 1994. L'objectif général du colloque était de rassembler les diverses compétences existant en France et à l'étranger dans le domaine de l'évaluation et de la gestion des risques naturels et de confronter les expériences acquises à l'interface entre les villes en croissance et le champ d'action des phénomènes naturels créateurs de risques. Le colloque a donc réuni des chercheurs, des doctorants et des praticiens de 12 pays, chargés de prévention, de gestion des risques naturels et de gestion urbaine, principalement dans les grandes villes des pays en développement (P.E.D.).Les contributions ont été regroupées, exposées et discutées lors du colloque sous forme de 3 thèmes : (1) Les phénomènes naturels créateurs de dommages (= menaces) : diagnostic, inventaire et typologie, (2) Les vulnérabilités des sociétés et des espaces urbanisés : concepts, typologie et modes d'analyse, (3) Les outils d'aide à la prévention et à la gestion du risque en milieu urbain. Certaines d'entre elles ont fait l'objet des quatre articles de ce Bulletin de l'Association de Géographes Français.
Colloque international : "Croissance urbaine et risques naturels dans les pays en développement"
Clermont-Ferrand, Université Blaise Pascal, France

ISBN : 0004-5322
hal-01165290
https://hal.archives-ouvertes.fr/hal-01165290

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Children are exposed to toxic metals and metalloids via their diet and environment. Our objective was to assess the aggregate chronic exposure of children aged 3–6 years, living in France, to As, Cd, Cr, Cu, Mn, Pb, Sb, Sr, and V present in diet, tap water, air, soil and floor dust in the years 2007–2009. Dietary data came from the French Total Diet Study, while concentrations in residential tap water, soil and indoor floor dust came from the ‘Plomb-Habitat’ nationwide representative survey on children's lead exposure at home. Indoor air concentrations were assumed to be equal to outdoor air concentrations, which were retrieved from regulatory measurements networks. Human exposure factors were retrieved from literature. Data were combined with Monte Carlo simulations. Median exposures were 1.7, 0.3, 10.2, 34.1, 60.3, 0.7, 0.1, 44.3, 1.5 and 95th percentiles were 4.4, 0.5, 15.8, 61.3, 98.3, 2.5, 0.1, 111.1, 2.9 μg/kg bw/d for As, Cd, Cr, Cu, Mn, Pb, Sb, Sr, and V respectively. Dietary exposures dominate aggregate exposures, with the notable exception of Pb - for which soils and indoor floor dust ingestion contribute most at the 95th percentile. The strengths of this study are that it aggregates exposures that are often estimated separately, and uses a large amount of representative data. This assessment is limited to main diet and residential exposure, and does not take into account the relative bioavailability of compounds. These results could be used to help target prevention strategies.
ISSN: 0160-4120

inserm-01404061
http://www.hal.inserm.fr/inserm-01404061
http://www.hal.inserm.fr/inserm-01404061/document
http://www.hal.inserm.fr/inserm-01404061/file/rev1%20-%20MS%20Expo%20metals.pdf
DOI : 10.1016/j.envint.2016.10.009

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
BACKGROUND: Thrombophilias are common disorders that increase the risk of pregnancy-associated venous thromboembolism and pregnancy loss and can also increase the risk of placenta-mediated pregnancy complications (severe pre-eclampsia, small-for-gestational-age infants, and placental abruption). We postulated that antepartum dalteparin would reduce these complications in pregnant women with thrombophilia. METHODS: In this open-label randomised trial undertaken in 36 tertiary care centres in five countries, we enrolled consenting pregnant women with thrombophilia at increased risk of venous thromboembolism or with previous placenta-mediated pregnancy complications. Eligible participants were randomly allocated in a 1:1 ratio to either antepartum prophylactic dose dalteparin (5000 international units once daily up to 20 weeks' gestation, and twice daily thereafter until at least 37 weeks' gestation) or to no antepartum dalteparin (control group). Randomisation was done by a web-based randomisation system, and was stratified by country and gestational age at randomisation day with a permuted block design (block sizes 4 and 8). At randomisation, site pharmacists (or delegates) received a randomisation number and treatment allocation (by fax and/or e-mail) from the central web randomisation system and then dispensed study drug to the local coordinator. Patients and study personnel were not masked to treatment assignment, but the outcome adjudicators were masked. The primary composite outcome was independently adjudicated severe or early-onset pre-eclampsia, small-for-gestational-age infant (birthweight <10th percentile), pregnancy loss, or venous thromboembolism. We did intention-to-treat and on-treatment analyses. This trial is registered with ClinicalTrials.gov, number NCT00967382, and with Current Controlled Trials, number ISRCTN87441504. FINDINGS: Between Feb 28, 2000, and Sept 14, 2012, 292 women consented to participate and were randomly assigned to the two groups. Three women were excluded after randomisation because of ineligibility (two in the antepartum dalteparin group and one in the control group), leaving 146 women assigned to antepartum dalteparin and 143 assigned to no antepartum dalteparin. Some patients crossed over to the other group during treatment, and therefore for on-treatment and safety analysis there were 143 patients in the dalteparin group and 141 in the no dalteparin group. Dalteparin did not reduce the incidence of the primary composite outcome in both intention-to-treat analysis (dalteparin 25/146 [17.1%; 95% CI 11.4-24.2%] vs no dalteparin 27/143 [18.9%; 95% CI 12.8-26.3%]; risk difference -1.8% [95% CI -10.6% to 7.1%)) and on-treatment analysis (dalteparin 28/143 [19.6%] vs no dalteparin 24/141 [17.0%]; risk difference +2.6% [95% CI -6.4 to 11.6%]). In safety analysis, the occurrence of major bleeding did not differ between the two groups. However, minor bleeding was more common in the dalteparin group (28/143 [19.6%]) than in the no dalteparin group (13/141 [9.2%]; risk difference 10.4%, 95% CI 2.3-18.4; p=0.01). INTERPRETATION: Antepartum prophylactic dalteparin does not reduce the occurrence of venous thromboembolism, pregnancy loss, or placenta-mediated pregnancy complications in pregnant women with thrombophilia at high risk of these complications and is associated with an increased risk of minor bleeding. FUNDING: Canadian Institutes of Health Research, Heart and Stroke Foundation of Canada, and Pharmacia and UpJohn.
ISSN: 0923-7577

hal-01258557
http://hal.univ-brest.fr/hal-01258557
DOI : 10.1016/S0140-6736(14)60793-5
PUBMED : 25066248

Éditeur(s) : HAL CCSD
Résumé : Food-grade dairy propionibacteria release beneficial short chain fatty acids (SCFAs), folic acid and cobalamin. They induce apoptosis via the mitochondrial death pathway. We investigated their synergy with drugs used in gastric and colorectal cancer.Fermented milk containing propionibacteria and SCFAS acetate and propionate, as well as its cell-free supernatant, induced apoptosis in gastric HGT-1 and colic HT-29. Characterization of cells revealed apoptosis induction evidenced by chromatin condensation, DNA laddering, emergence of a subG1 population, phosphatidylserine exposure at the plasma membrane outer leaflet and cytochrome c release. Interestingly, the fermented milk was shown to potentiate the cytotoxic effect of molecules used in cancer chemotherapy, camptothecin and TRAIL (TNF Related Apoptosis Inducing Ligand).These results open new perspectives in the field of colon cancer cells prevention and/or treatment. Such a fermented product, or the propionibacterium alone, may be proposed as a food supplement to enhance the effects of anticancer treatments.
Les bactéries propioniques laitières produisent des acides gras volatils (AGV), acide folique et cobalamine, composés bénéfiques. Elles induisent l’apoptose via la voie mitochondriale. Nous avons recherché leur synergie avec des drogues utilisées dans le cancer gastrique ou colique.Un lait fermenté contenant des bactéries propioniques et les AGVs propionate et acétate a induit l’apoptose de cellules gastriques HGT-1 et coliques HT-29. L’étude des cellules a révélé l’induction de l’apoptose : condensation de la chromatine, fragmentation de l’ADN, l’émergence d’une population subG1, l’externalisation des phosphatidylserines et le relargage du cytochrome c. De manière intéressante, le lait fermenté a potentialisé les effets cytotoxiques de molécules utilisées en chimiothérapie, camptothécine et TRAIL (TNF Related Apoptosis Inducing Ligand).Ces résultats ouvrent de nouvelles perspectives dans le domaine du traitement ou de la prévention des cancers digestifs. Un tel produit fermenté, ou les propionibactéries seules, pourrait être proposé comme supplément alimentaire pour augmenter l’efficacité de traitements anti-cancéreux.
5. Colloque Intenational Molécules & Ingrédients Santé
Quimper, France

hal-01204307
https://hal.archives-ouvertes.fr/hal-01204307
PRODINRA : 261444

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : This document shows several of the main findings of the research work in the towns of San Juan de los Lagos and Santa Ana de Guadalupe, Jalostotitlán, Mexico, on the occasion of knowing the impact it has had the policy used by the Ministry of Tourism, regarding the promotion of religious tourism in both populations as a source for economic development.Among the findings are that the project whose intent is to develop a similar route to that of the "Camino de Santiago" in Spain, and include both populations is often unknown to visitors to these religious sites.Another important result concerns the data were limited marketing of products manufactured locally or regionally. This prevents the economic benefits of religious tourism that visits this population, have very little benefit to people nearby.
Cet article propose quelques-unes des principales conclusions de la recherche menée dans les villes de San Juan de los Lagos et Santa Ana de Guadalupe, Jalostotitlán, au Mexique, sur l'impact de la politique menée par le ministère du tourisme en matière de promotion du tourisme religieux comme source potentielle de développement économique.L’accent est mis sur le projet d’une route similaire à la "Camino de Santiago" en Espagne dont le but est d’impliquer les populations dans l’accueil des visiteurs et la mise en valeur des sites religieux. Un autre résultat important concerne la commercialisation des produits fabriqués localement ou régionalement. Cela permet d'éviter les retombées économiques du tourisme profitent davantage aux villes voisines qu’aux populations locales.
El presente documento, muestras varios de los principales hallazgos del trabajo de investigación realizado en las poblaciones de San Juan de los Lagos y Santa Ana de Guadalupe, Jalostotitlán, México, con motivo de conocer el impacto que ha tenido la política utilizada por la Secretaría de Turismo, referente a la promoción del turismo religioso en ambas poblaciones como fuente generadora para su desarrollo económico.Entre los hallazgos, se encuentran que el proyecto cuya intensión es desarrollar una ruta similar a la del "camino de Santiago" en España, y que incluiría ambas poblaciones, es desconcida para los visitantes a estos sitios religiosos.Otro resultado importante, se refiere a la escaza comercialización de productos manufacturados en de manera local o regional. Este hecho impide que los beneficios económicos del turismo religioso que visita esta poblaciones, tenga muy poco beneficio para las poblaciones vecinas.
San Juan de los Lagos
Jalostotitlán
Mexique

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.5352
http://journals.openedition.org/etudescaribeennes/5352

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Previous work has demonstrated that geoelectrical measurements, acquired either along the Earth’s surface or in boreholes, can be sensitive to the presence of fractures. However, a lack of numerical approaches that are well suited to modelling electric current flow in fractured media prevents us from systematically exploring the links between geoelectrical measurements and fractured rock properties. To address this issue, we present a highly computationally efficient methodology for the numerical simulation of geoelectrical data in 2.5-D in complex fractured domains. Our approach is based upon a discrete-dual-porosity formulation, whereby the fractures and rock matrix are treated separately and coupled through the exchange of electric current between them. We first validate our methodology against standard analytical and finite-element solutions. Subsequent use of the approach to simulate geoelectrical data for a variety of different fracture configurations demonstrates the sensitivity of these data to important parameters such as the fracture density, depth, and orientation.
ISSN: 0956-540X

hal-01622151
https://hal.archives-ouvertes.fr/hal-01622151
https://hal.archives-ouvertes.fr/hal-01622151/document
https://hal.archives-ouvertes.fr/hal-01622151/file/sanzGJI2017.pdf
DOI : 10.1093/gji/ggx080

Éditeur(s) : HAL CCSD
Résumé : International audience
Effective and sustainable prevention of work-related musculoskeletal disorders (WR-MSDs) remains a challenge for preventers and policy makers. Coordination of stakeholders involved in the prevention of WR-MSDs is a key factor that requires greater reflection on common knowledge and shared representation of workers’ activities among stakeholders. Information on workers’ strategies and operational leeway should be the core of common representations, since it places workers at the center of the “work situation system” considered by the intervention models. Participatory ergonomics permitting debates among stakeholders about workers’ activity and strategies to cope with the work constraints in practice could help them to share representations of the “work situation system” and cooperate. Sharing representation therefore represents a useful tool for prevention, and preventers should provide sufficient space and time for dialogue and discussion of workers’ activities among stakeholders during the conception, implementation and management of integrated prevention programs
Safety and Health at Work

hal-01279095
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01279095
DOI : 10.1016/j.shaw.2016.02.001
PUBMED : 27340607

Éditeur(s) : HAL CCSD
Résumé : National audience
Aspirin (acetylsalicylic acid) has been used ever since the Antiquity for its painkilling and anti-inflammatory effects. Its antiplatelet properties have then extended its indications to the field of coronaropathy and vascular cerebral disease, and finally to vascular placental disease. Aspirin has been widely prescribed since the 1980's to prevent pre-eclampsia, intra-uterine growth retardation and fetal death of vascular origin. It has also been proposed to prevent unexplained recurrent miscarriages. Its use during pregnancy is considered as safe, provided the daily doses do not exceed 100mg. Aspirin has been proven efficient to prevent pre-eclampsia and fetal growth restriction in high-risk patients. The benefits of prescribing aspirin have been demonstrated neither for vascular placental disease prevention in low risk patients, nor in cases of unexplained recurrent miscarriages.
La Revue De Medecine Interne

hal-01659441
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01659441
DOI : 10.1016/j.revmed.2017.10.419
PUBMED : 29129461

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
BOI1 and BOI2 are paralogs important for the actin cytoskeleton andpolar growth. BOI1 encodes a meiotic transcript isoform with an extended5-untranslated region predicted to impair protein translation. It is,however, unknown how the isoform is repressed during mitosis, and ifBoi1 is present during sporulation. By interpreting microarray data fromMATa cells, MATa/ cells, a starving MAT/ control, and a meiosis-impairedrrp6 mutant, we classified BOI1's extended isoform as earlymeiosis-specific. These results were confirmed by RNA-Sequencing, andextended by a 5-RACE assay and Northern blotting, showing that meioticcells induce the long isoform while the mitotic isoform remainsdetectable during meiosis. We provide evidence via motif predictions, anin vivo binding assay and genetic experiments that the Rpd3/Sin3/Ume6histone deacetylase complex, which represses meiotic genes duringmitosis, also prevents the induction of BOI1's 5-extended isoform inmitosis by direct binding of Ume6 to its URS1 target. Finally, we findthat Boi1 protein levels decline when cells switch from fermentation torespiration and sporulation. The histone deacetylase Rpd3 is conserved,and eukaryotic genes frequently encode transcripts with variable 5-UTRs.Our findings are therefore relevant for regulatory mechanisms involvedin the control of transcript isoforms in multi-cellular organisms.
ISSN: 0950-382X

hal-01122120
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01122120
DOI : 10.1111/mmi.12976
PUBMED : 25708805