Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Joint inversions are now commonly used in the earth sciences. They have been developed to better understand the structure of the earth, since they provide more constraints on the inverted parameters. We propose a new process to simultaneously invert several data sets in order to better image 3D crustal and upper mantle structures. Our inversion uses three kinds of data that present good complementarity: (1) P-wave receiver functions to provide Moho depth variations, (2) teleseismic delay times of P-waves to retrieve velocity anomalies in the crust and the upper mantle, and (3) gravity anomalies to image density variations at the lithospheric scale. We use a stochastic scheme, where receiver functions are first inverted. The interpolated resulting Moho depths are incorporated as a priori information into the joint inversion of teleseismic delay times and gravity anomalies process. Moreover, velocity and density can be linked by empirical relationships, which justifies the joint inversion of those parameters. In our stochastic approach, we perform a model space search for Moho variations, P-velocity, and density structure to find an acceptable fit to the three data sets. In order to preferentially sample the good data fit regions, we chose the neighborhood algorithm of Sambridge to optimistically survey the model space. We model the delay times with 3D raytracing using evenly spaced velocity-density nodes. We present here the first results given by this method on synthetic tests. (C) 2011 Elsevier Ltd. All rights reserved.
ISSN: 0098-3004

hal-00643158
https://hal.archives-ouvertes.fr/hal-00643158
DOI : 10.1016/j.cageo.2010.11.017

Éditeur(s) : HAL CCSD Société géologique de France
Résumé : In the western Mediterranean Sea, the Liguro-Provençal Basin (LPB) is a key area for studying passive margins because of its recent formation and abundance of onshore and offshore data. The Nerthe area located in the northern margin of LPB provides the unique continuous Oligo-Miocene deposits contemporaneous of the transition rifting to drifting. However, the age of the deposits remains debated and the link between outcrops and offshore seismic data is poorly constrained. The purpose of this paper is double. First, we intend to propose a new chronostratigraphic frame based on bio- (planktonic foraminifera, calcareous nannofossils) and magneto-stratigraphy. Second, we aim to make, through the integration of new highly time-resolved seismic data and field works, a coherent onshore-offshore link concretized by a 3D geological model. The new temporal and spatial data presented in this paper allow correlating the Oligo-Miocene sequences, defining their geometry and specifying precisely the timing of syn- and post-rift stages. The first marine transgression is now precisely dated latest Chattian within the syn-rift deposits and appears to be synchronous with the first marine deposits in the offshore wells and other marginal basins. The transition from syn-rift to post-rift appears to last 3.3 Ma at maximum, between 21.8 and 18.5 Ma (late Aquitanian to early Burdigalian). It is underlined by two major erosional unconformities bearing a hiatus of around 1 Ma. The post-rift started with a major marine transgression that is now dated from middle Burdigalian, at around 18.5 Ma, as elsewhere in the LPB. Contrarily to recent proposals, the post-rift deposits are widely represented on the northeastern margin of the "Golfe du Lion". There, the subsidence of the margin was low during the syn-rift and the transitional periods and high during the post-rift. The onset of this high post-rift subsidence appears to be synchronous with the slowdown of the Corsica-Sardinia block (CSb) motion.
EISSN: 1777-5817

hal-00558497
https://hal.archives-ouvertes.fr/hal-00558497
DOI : 10.2113/gssgfbull.181.6.591

Éditeur(s) : HAL CCSD Elsevier
Résumé : A combination of statistical studies on present-day subduction zones and three-dimensional (3D) laboratory models is performed with the aim to clarify the way that plate kinematics control the geometry of the slab and the overriding plate deformation in subduction zones. In 3D laboratory models, the analogue of a two layer linearly viscous lithosphere–upper mantle system is achieved by means of silicon putty glucose syrup tank experiment. The subducting and overriding plate velocities are systematically changed by exploring the variability field of natural plate kinematics. Both statistical and modelling approaches recognize the importance of overriding plate motion on subduction process behavior: (1) trenches migrate at a rate close to the overriding plate motion, but always move slower than the overriding plates. The mechanism at work is a direct consequence of “slab anchoring” opposed by both lithosphere and mantle viscous resistance and is responsible for overriding plate deformation and slab geometry variability. (2) An overriding plate shortens when the overriding plate moves toward the trench and conditions that are favourable for overriding plate extension are created when the overriding plate moves away from the trench. (3) Shallow and steep dips are found if the overriding plate moves toward and away from the trench, respectively.
ISSN: 0012-821X

hal-00406598
https://hal.archives-ouvertes.fr/hal-00406598
DOI : 10.1016/j.epsl.2007.02.004

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The kinetics of hydrogenation of dry iron-bearing olivine single crystals was determined by performing hydration experiments under hydrothermal conditions at high pressure. The experiments were performed in a multi-anvil press at 3 GPa, for a temperature range between 900 and 1200 °C and for various durations. The oxygen fugacity was buffered along Ni-NiO joint. Polarized Fourier transform infrared spectroscopy and recent empirical calibration were used to quantify the hydroxyl distributions in the samples along crystallographic axes after the experiments. The chemical diffusion coefficients are similar (barely slower) than in olivine hydrated at lower pressure (0.2 and 0.3 GPa) for the same diffusion mechanism. Under the given experimental conditions, the anisotropy of diffusion is the same as for proton-vacancy mechanism, with diffusion along the [0 0 1] axis faster than along the [1 0 0]. However, the anisotropy at 3 GPa is weaker compared to measurements at lower pressures and the analysis of concentration profiles using 3D models shows that an isotropic solution could also be relevant. Fits of the diffusion data to an Arrhenius law yield activation energies for the slightly faster [0 0 1] axis of the crystallographic axes around 198 ± 5 kJ mol−1, a value only slightly lower than the results from previous experimental studies for natural iron-bearing olivine hydrogenated at lower confining pressure. At 3 GPa, hydrogenation can be well approximated by a single mechanism controlled by coupled diffusion of protons and octahedral vacancies (di- and tri-valent ions). The diffusion rates are fast enough to alter hydrogen concentration within olivine in xenoliths ascending from the mantle or experiencing hydrogen-rich metasomatism events, but too slow to permit complete homogenization of hydrogen in olivine-rich rocks at kilometer scale in less than one My.
ISSN: 0031-9201

hal-01412663
https://hal.archives-ouvertes.fr/hal-01412663
DOI : 10.1016/j.pepi.2016.08.005

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
The Convective and Orographically-driven Precipitation Study (COPS) carried out in summer 2007 over northeastern France and southwestern Germany provided a fairly comprehensive description of the low-troposphere water-vapour field, thanks in particular to the deployment of two airborne differential absorption lidar systems. These lidar observations were assimilated using the 3D-Var assimilation system of the Application of Research to Operations at MEsoscale (AROME) numerical weather prediction mesoscale model. The assimilation was carried out for the period 4 July-3 August by running a three-hour forward intermittent assimilation cycle. First, the impact of the lidar observations was assessed by comparing the analyses with a set of more than 200 independent soundings. The lidar observations were found to have a positive impact on the analyses by reducing the dry bias in the first 500 m above ground level and by diminishing the root-mean-square error by roughly 15% in the first km. Then the impact of the lidar observations was assessed by comparing the precipitation forecasts (obtained with and without the lidar observations for the period 15 July-2 August) with the gridded precipitation observations provided by the Vienna Enhanced Resolution Analysis. In general, the impact was found to be positive but not significant for the 24 h precipitation and positive and significant for the 6 h precipitation, with an improvement lasting up to 24 h. Some selected case studies show that the improvement was obtained through a better depiction of convection initiation or through a more accurate positioning of the precipitation systems
ISSN: 0035-9009

hal-00659497
https://hal.archives-ouvertes.fr/hal-00659497
DOI : 10.1002/qj.1864

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
From 15 to 17 June 2011, a dedicated workshop was held on the subject of in vitro models for mammalian spermatogenesis and their applications in toxicological hazard and risk assessment. The workshop was sponsored by the Dutch ASAT initiative (Assuring Safety without Animal Testing), which aims at promoting innovative approaches toward toxicological hazard and risk assessment on the basis of human and in vitro data, and replacement of animal studies. Participants addressed the state of the art regarding human and animal evidence for compound mediated testicular toxicity, reviewed existing alternative assay models, and brainstormed about future approaches, specifically considering tissue engineering. The workshop recognized the specific complexity of testicular function exemplified by dedicated cell types with distinct functionalities, as well as different cell compartments in terms of microenvironment and extracellular matrix components. This complexity hampers quick results in the realm of alternative models. Nevertheless, progress has been achieved in recent years, and innovative approaches in tissue engineering may open new avenues for mimicking testicular function in vitro. Although feasible, significant investment is deemed essential to be able to bring new ideas into practice in the laboratory. For the advancement of in vitro testicular toxicity testing, one of the most sensitive end points in regulatory reproductive toxicity testing, such an investment is highly desirable.
ISSN: 0890-6238

hal-00876979
https://hal.archives-ouvertes.fr/hal-00876979
DOI : 10.1016/j.reprotox.2013.04.004
PUBMED : 23612449

Éditeur(s) : HAL CCSD Geological Society of London
Résumé : International audience
The mylonitic Cambrian quartzites, Moine Thrust Zone, NW Scotland, have long been used to study microstructural and petrofabric evolution and to develop understanding of grain-scale processes accommodating large-scale displacements. Today, structural geology is entering a new age of understanding of the basic processes involved in microstructural evolution due to the emergence of novel instrumental techniques and theoretical models. It seems apposite therefore to re-evaluate the microstructure of one example of this classic quartz mylonite from the Stack of Glencoul, Assynt, using arguably the most important of these new techniques, electron backscattered diffraction (EBSD). The three-dimensional (3D) microstructure and petrofabric of this rock was analysed using EBSD, to: 1) corroborate previous optical and X-ray texture goniometry measurements; 2) investigate the potential for sampling and/or tectonic sectioning bias that may be introduced inadvertently into any petrofabric analysis; and 3) predict its seismic properties. It is found that microstructures do differ between orthogonal structural sections, leading to variations in strengths of different components in the overall petrofabric that might impact on seismic properties. The results emphasize the true 3D nature of microstructures and petrofabrics, which can be recognized and accommodated more readily by this new generation of analytical techniques.
Continental Tectonics and Mountain Building: The Legacy of Peach and Horne

hal-00565749
https://hal.archives-ouvertes.fr/hal-00565749

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
The seismological study of recent seismic crises near Oleron Island confirms the coexistence of an extensional deformation and a transtensive regime in the Atlantic margin of France, which is different from the general western European stress field corresponding to a strike-slip regime. We argue that the switch of the principal stress axes σ1/σ2 in a NW-SE vertical plane is linked with the existence of crustal heterogeneities. Events of magnitude larger than 5 sometimes occur along the Atlantic margin of France, such as the 7 September 1972 (ML = 5.2) earthquake near Oleron island and the 30 September 2002 (ML = 5.7) Hennebont event in Brittany. To test the mechanism of local strain localization, we model the deformation of the hypocentral area of the Hennebont earthquake using a 3D thermo-mechanical finite element code. We conclude that the occurrence of moderate earthquakes located in limited parts of the Hercynian shear zones (as the often reactivated swarms near Oleron) could be due to local reactivation of pre-existing faults. These sporadic seismic ruptures are favoured by stress concentration due to rheological heterogeneities.
ISSN: 1631-0713

hal-00936220
https://hal.archives-ouvertes.fr/hal-00936220
DOI : 10.1016/j.crte.2013.07.004

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : Some major challenges for geophysicists and structural geologists using three-dimensional boundary element method codes (3D-BEM) are: (1) reducing the amount of memory required to solve large and dense systems and (2) incorporation of inequality constraints such as traction inequality constraints (TIC) and displacement inequality constraints (DIC). The latter serves two purposes. First, for example, inequality constraints can be used to simulate frictional slip (using TIC). Second, these constraints can prevent element interpenetration while allowing opening mode (using DIC). We have developed a method that simultaneously incorporates both types of functionality of the inequality constraints. We show that the use of an appropriate iterative solver not only avoids the allocation of significant memory for solving the system (allowing very large model computation and simplifying parallelization on multi-core processors), but also admits interesting features such as natural incorporation of TICs and DICs. Compared to other techniques of contact management (e.g., Lagrange multipliers, penalty method, or complementarity problem), this new simple methodology, which does not use any incremental trial-and-error procedures, brings more flexibility, while making the system more stable and less subject to round-off errors without any computational overhead. We provide validations and comparisons of the inequality constraints implementation using 2D analytical and numerical solutions.
ISSN: 1420-0597

hal-00561035
https://hal.archives-ouvertes.fr/hal-00561035
DOI : 10.1007/s10596-009-9170-x

Éditeur(s) : HAL CCSD National Research Council Canada
Résumé : International audience
Back-arc extension in the Aegean, which was driven by slab rollback since 45 Ma, is described here for the first time in two stages. From Middle Eocene to Middle Miocene, deformation was localized leading to i) the exhumation of high-pressure metamorphic rocks to crustal depths, ii) the exhumation of high-temperature metamorphic rocks in core complexes and iii) the deposition of sedimentary basins. Since Middle Miocene, extension distributed over the whole Aegean domain controlled the deposition of onshore and offshore Neogene sedimentary basins. We reconstructed this two-stage evolution in 3D and four steps at Aegean scale by using available ages of metamorphic and sedimentary processes, geometry and kinematics of ductile deformation, paleomagnetic data and available tomographic models. The restoration model shows that the rate of trench retreat was around 0.6 cm/y during the first 30 My and then accelerated up to 3.2 cm/y during the last 15 My. The sharp transition observed in the mode of extension, localized versus distributed, in Middle Miocene correlates with the acceleration of trench retreat and is likely a consequence of the Hellenic slab tearing documented by mantle tomography. The development of large dextral NE-SW strike-slip faults, since Middle Miocene, is illustrated by the 450 Km-long fault zone, offshore from Myrthes to Ikaria and onshore from Izmir to Balikeshir, in western Anatolia. Therefore, the interaction between the Hellenic trench retreat and the westward displacement of Anatolia started in Middle Miocene, almost 10 Ma before the propagation of the North Anatolian Fault in the North Aegean.
ISSN: 0008-4077

insu-01271296
https://hal-insu.archives-ouvertes.fr/insu-01271296
https://hal-insu.archives-ouvertes.fr/insu-01271296/document
https://hal-insu.archives-ouvertes.fr/insu-01271296/file/Brun%20etal%20CJES%202016.pdf
DOI : 10.1139/cjes-2015-0203

Éditeur(s) : HAL CCSD
Résumé : International audience
The carbon capture and storage is considered as one of the solutions of reducing the effects of global warming. It consists in injecting large quantities of CO 2 in supercritical form directly into deeply located geological formations. One of the methods involves sequestration in the carbonate sedimentary rocks (sandstones and limestones) which are considered as a promising solution. The morphology of the pore network and solid skeleton defines important macroscopic prop-erties of the rock (permeability, stiffness). Modelling at micro scale of random heterogeneous materials (porous media) should be based on morphological and statistical characterisation 1,2 of the investigated microstructure. The work is focused on a reconstruction method by grains deposit 3 , for various range of pa-rameters, to obtain equivalent model of natural rock samples (oolitic limestone and fontainebleau sandstone). Generated samples satisfy morphological and statistical informations 4 which were obtained by 3D image analysis of X-ray tomography of the natural rock samples. For validation of the modelling numerical computations of mechanical and transfer properties are also provided.
14th European Mechanics of Materials Conference - EMMC14
Gothembourg, Sweden

hal-01103163
https://hal.archives-ouvertes.fr/hal-01103163

Éditeur(s) : HAL CCSD
Résumé : International audience
L’Open hardware constitue la dernière extension du mouvement dit du « Libre » en propriété intellectuelle. Si l’Open hardware procède également du numérique, son objet est constitué d’un « matériel libre », soit une série d’objets physiques dont la production, la distribution et le partage sont déclarés libres par un modèle de licence similaire à celui des logiciels. La création collaborative irrigue désormais des créations purement matérielles,plus précisément corporelles.
Les écosystèmes numériques et la démocratisation informationnelle : Intelligence collective, Développement durable, Interculturalité, Transfert de connaissances
Schoelcher, France

Droits : http://creativecommons.org/licenses/by-nc-nd/
hal-01265772
https://hal.univ-antilles.fr/hal-01265772
https://hal.univ-antilles.fr/hal-01265772/document
https://hal.univ-antilles.fr/hal-01265772/file/Philippe%20MOURON.pdf

Éditeur(s) : HAL CCSD
Résumé : International audience
Aegean extension is a process driven by slab rollback that, since 45 Ma, shows a twostage evolution. From Middle Eocene to Middle Miocene it is accommodated by localized deformation leading to i) the exhumation of high-pressure metamorphic rocks from mantle to crustal depths, ii) the exhumation of high-temperature rocks in core complexes and iii) the deposition of Paleogene sedimentary basins. Since Middle Miocene, extension is distributed over the whole Aegean domain giving a widespread development of onshore and offshore Neogene sedimentary basins. We reconstructed this two-stage evolution in 3D at Aegean scale by using available ages of metamorphic and sedimentary processes, geometry and kinematics of ductile deformation, paleomagnetic data and available tomographic models. The restorationmodel shows that the rate of trench retreat was around 0.6 cm/y during the first 30 My and then accelerated up to 3.2 cm/y during the last 15 My. The sharp transition observed in the mode of extension, localized versus distributed, which occurred in Middle Miocene correlates with the acceleration of trench retreat and is more likely a consequence of the Hellenic slab tearing documented by mantle tomography. The development of large dextral NE-SW strike-slip faults during the second stage of Aegean extension, since Middle Miocene, is illustrated by the 450 Km-long fault, recently put in evidence, offshore from Myrthes to Ikaria and onshore from Izmir to Balikeshir, in western Anatolia. Therefore, the interaction between the Hellenic trench retreat and the westward displacement of Anatolia started in Middle Miocene,almost 10 Ma before the propagation of the North Anatolian Fault in the North Aegean. This raises a fundamental issue concerning the dynamic relationship between slab tearing and Anatolia displacement
ISSN: 0438-9557

insu-01574659
https://hal-insu.archives-ouvertes.fr/insu-01574659
https://hal-insu.archives-ouvertes.fr/insu-01574659/document
https://hal-insu.archives-ouvertes.fr/insu-01574659/file/EFFECTS_OF_SLAB_ROLLBACK_ACCELERATION_ON_AEGEAN_EX.pdf
DOI : 10.12681/bgsg.11697

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Among persisting questions on bone calcification, a major one is the link between protein expression and mineral deposition. A cell culture system is here proposed opening new integrative studies on biomineralization, improving our knowledge on the role played by non-collagenous proteins in bone. This experimental in vitro model consisted in human primary osteoblasts cultured for 60 days at the surface of a 3D collagen scaffold mimicking an osteoid matrix. Various techniques were used to analyze the results at the cellular and molecular level (adhesion and viability tests, histology and electron microscopy, RT-and qPCR) and to characterize the mineral phase (histological staining, EDX, ATG, SAED and RMN). On long term cultures human bone cells seeded on the osteoid-like matrix displayed a clear osteoblast phenotype as revealed by the osteoblast-like morphology, expression of specific protein such as alkaline phosphatase and expression of eight genes classically considered as osteoblast markers, including BGLAP, COL1A1, and BMP2. Von Kossa and alizarine red allowed us to identify divalent calcium ions at the surface of the matrix, EDX revealed the correct Ca/P ratio, and SAED showed the apatite crystal diffraction pattern. In addition RMN led to the conclusion that contaminant phases were absent and that the hydration state of the mineral was similar to fresh bone. A temporal correlation was established between quantified gene expression of DMP1 and IBSP, and the presence of hydroxyapatite, confirming the contribution of these proteins to the mineralization process. In parallel a difference was observed in the expression pattern of SPP1 and BGLAP, which questioned their attributed role in the literature. The present model opens new experimental possibilities to study spatio-temporal relations between bone cells, dense collagen scaffolds, NCPs and hydroxyapatite mineral deposition. It also emphasizes the importance of high collagen density environment in bone cell physiology.
ISSN: 1932-6203

hal-01142641
http://hal.upmc.fr/hal-01142641
http://hal.upmc.fr/hal-01142641/document
http://hal.upmc.fr/hal-01142641/file/Silvent_2013_Collagen.pdf
DOI : 10.1371/journal.pone.0057344

Éditeur(s) : HAL CCSD
Résumé : Gravitropism is a major process in vertical growth as it allows the positioning of plant in the gravity field and thus, for trees, it takes part in the light foraging strategies. Without any gravitropism, trees would adopt a weeping habit or fall on the ground due to the increasing with growth supported weight, especially at the advance regeneration stage (sapling stage) in the understorey, where tree are very slender and poorly stiff. Most of the gravitropic studies are made by physiologists in order to understand the process and thus are associated to complex laboratory methods (genetic engineering, anatomical studies, accurate 2D ou 3D measurements of form changes with time). In order to study the ecological relevance and the specific diversity of gravitropic performances in natural forests, we developed a framework that uses different kinds of datas. Synchronical analysis has been done i) at the population level in large sample of trees and ii) at the tree level from destructive measurement of the dissymmetry maturation strains known to be the main motor of the posture control reaction of trees. In both cases, biomechanical models allows to estimate some aspects of the dynamic gravitropic process. Diachronical analysis has been done in natural conditions on permanent plots, or in a more traditional way, by observing in greenhouse experiments the righting movements of plants artificially tilted. In the first case, the problem is the high variability of natural disturbances and the slowness of growth and movements in the dark understorey. The second choice allows a measurement of a capacity (i.e. the ability of the species to react in quite extreme conditions of verticality disturbance but good for growth light and nutrient conditions) that is more easy to analyse, but is maybe not so relevant for estimating the ecological strategy (some species could have developed a high efficience of gravitropic reaction in natural conditions by avoiding the mechanical disturbance or adapting the reaction to slow growth and changing environments in natural conditions). All approaches use the same basic biomechanical modelling, i) to analyse simultaneously the reaction and the disturbance (due to the weight increase) during growth, or ii) to combine different parameters (geometry, growth, weight, maturation strains) involved in shape changes and posture control. They give a classification of the species according to their gravitropic performances. Results on 15 species are discussed, with relation to shade-tolerance or avoidance.
6th Plant Biomechanics Conference
Cayenne, France

hal-00565956
https://hal.archives-ouvertes.fr/hal-00565956

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Wallace (1951) and Bott (1959) were the first to introduce the idea that the slip on each fault surface has the same direction and sense as the maximum shear stress resolved on that surface. However, this simplified hypothesis is questionable since fault mechanical interactions may induce slip reorientations. Earlier numerical geomechanical models confirmed that the slickenlines (slip vectors) are not necessarily parallel to the maximum resolved shear stress but are consistent with local stress perturbations. This leads us to ask as to what extent the Wallace and Bott simplifications are reliable as a basis hypothesis for stress inversion from fault slip data. Here, a geomechanical multi-parametric study using a 3D boundary element method, covering (i) fault geometries such as intersected faults or corrugated fault surfaces, (ii) the full range of Andersonian state of stress, (iii) fault friction, (iv) fault fluid pressure, (v) half space effect and (vi), rock properties, is performed in order to understand the effect of each parameter on the misfit angle between geomechanical slip vectors and the resolved shear stresses. It is shown that significant misfit angles can be found under specific configurations invalidating the Wallace and Bott assumptions, even though fault friction tends to minimize the misfit. We therefore conclude that in such cases, stress inversions based on fault slip data should be interpreted with care.
ISSN: 0040-1951

hal-01218418
https://hal.archives-ouvertes.fr/hal-01218418
DOI : 10.1016/j.tecto.2015.06.030

Éditeur(s) : HAL CCSD IEEE
Résumé : International audience
The main challenge in prostate cancer radiotherapy is to deliver the prescribed dose to the clinical target while minimizing the dose to the neighboring organs at risk and thus avoiding subsequent toxicity-related events. With the aim of improving toxicity prediction following prostate cancer radiotherapy, the goal of our work is to propose a new predictive variable computed with independent component analysis to predict late rectal toxicity, and to compare its performance to other models (logistic regression, normal tissue complication probability model and recent principal component analysis approach). Clinical data and dose-volume histograms were collected from 216 patients having received 3D conformal radiation for prostate cancer with at least two years of follow-up. Independent component analysis was trained to predict the risk of 3-year rectal bleeding Grade extgreater= 2. The performance of all the models was assessed by computing the area under the receiving operating characteristic curve. Clinical parameters combined with the new variable were found to be predictors of rectal bleeding. The mean area under the receiving operating curve for our proposed approach was 0:75. The AUC values for the logistic regression, the Lyman-Kutcher-Burman model and the recent principal component analysis approach were 0:62, 0:53 and 0:62, respectively. Our proposed new variable may be an useful new tool in predicting late rectal toxicity. It appears as a strong predictive variable to improve classical models
2015 37th annual international conference of the IEEE Engineering in Medicine and Biology Society
Milan, Italy

hal-01304750
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01304750

Éditeur(s) : HAL CCSD AGU and the Geochemical Society
Résumé : International audience
A NE-SW magnetotelluric 110 km-long profile including 18 sites was acquired across the western Rif Cordillera along the Eurasian-African plate boundary, allowing to constrain its poorly known deep structure. It extends from the Internal Zones, close to the Alboran coast, crossing the External Zones and up to the Gharb foreland basin. The periods recorded range from 0.001 s to 1000 s. The combination of magnetotelluric data with available geological data provides new insight regarding the relationship between deep and shallow crustal structures of the Rif Cordillera. Analyses of structural dimensionality suggest a preferential NW-SE direction, and a 2D joint inversion was performed. A 3D inversion extending the 2D model along the strike confirmed the reliability of this approach. The magnetotelluric model shows a heterogeneous upper crust in agreement with the geological structures observed at surface. The Internal Zones correspond to resistive (metamorphic rocks) and conductive (peridotites) bodies, while the External Zones and the foreland basin are characterized by large conductive bodies of variable thickness. A crustal detachment level separating shallow geological units from a probable variscan basement was inferred. At depth, the most relevant feature consists of large resistive bodies with a shallow irregular top, located below the frontal part of the Rif. The outcrops of exotic metapelitic, granitic and gneissic blocks in the frontal part of the Cordillera suggest that these large resistive bodies may correspond to a gneissic or granitic basement surrounded by metapelitic rocks. Late contractive thrust and diapiric processes were responsible for their uplift and shallow emplacement. The Rif constitutes an active southwestward vergent orogenic wedge, oblique to the present-day NW-SE convergent Eurasian-African plate boundary.
ISSN: 1525-2027

hal-00670999
https://hal.archives-ouvertes.fr/hal-00670999
DOI : 10.1029/2011GC003783

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Second harmonic generation (SHG) microscopy is a powerful tool for studying submicron architecture of muscles tissues. Using this technique, we show that the canonical single frequency sarcomeric SHG intensity pattern (SHG-IP) of premetamorphic xenopus tadpole tail muscles is converted to double frequency (2f) sarcomeric SHG-IP in metamorphic climax stages due to massive physiological muscle proteolysis. This conversion was found to rise from 7% in premetamorphic muscles to about 97% in fragmented muscular apoptotic bodies. Moreover a 66% conversion was also found in non-fragmented metamorphic tail muscles. Also, a strong correlation between predominant 2f sarcomeric SHG-IPs and myofibrillar misalignment is established with electron microscopy. Experimental and theoretical results demonstrate the higher sensitivity and the supra resolution power of SHG microscopy over TPEF to reveal 3D myofibrillar misalignment. From this study, we suggest that 2f sarcomeric SHG-IP could be used as signature of triad defect and disruption of excitation–contraction coupling. As the mechanism of muscle proteolysis is similar to that found in mdx mouse muscles, we further suggest that xenopus tadpole tail resorption at climax stages could be used as an alternative or complementary model of Duchene muscular dystrophy.
ISSN: 1047-8477

hal-01134174
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134174
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134174/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134174/file/Recher%20et%20al_JSB-2015_hal.pdf
DOI : 10.1016/j.jsb.2015.03.003

Éditeur(s) : HAL CCSD Taylor & Francis: STM, Behavioural Science and Public Health Titles
Résumé : International audience
The dislocation microstructures in a single crystal of olivine deformed experimentally in uniaxial compression at 1090 °C and under a confining pressure of 300 MPa, have been investigated by transmission electron tomography in order to better understand deformation mechanisms at the microscale relevant for lithospheric mantle deformations. Investigation by electron tomography reveals microstructures, which are more complex than previously described, composed of and dislocations commonly exhibiting 3D configurations. Numerous mechanisms such as climb, cross-slip, double cross-slip as well as interactions like junction formations and collinear annihilations are the source of this complexity. The diversity observed advocates for microscale deformation of olivine significantly less simple than classic dislocation creep reported in metals or ice close to melting temperature. Deciphering mechanism of hardening in olivine at temperatures where ionic diffusion is slow and is then expected to play very little role is crucial to better understand and thus model deformation at larger scale and at temperatures (900–1100 °C) highly relevant for the lithospheric mantle.
ISSN: 1478-6443

hal-01667146
https://hal.archives-ouvertes.fr/hal-01667146
DOI : 10.1080/14786435.2017.1367858