Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
Background: Two antifibrotic drugs, pirfenidone and nintedanib, are approved by the European Medicines Agency and the US Food and Drug Administration for the treatment of idiopathic pulmonary fibrosis (IPF). In this analysis, treatment patterns of European patients with IPF were investigated to understand antifibrotic prescribing and identify unmet needs in IPF treatment practice. Methods: Between February and March 2016, respiratory physicians from France, Germany, Italy, Spain, and the UK participated in an online questionnaire designed to collect information on IPF treatment patterns in patients under their care. Patients were categorized as treated (received approved antifibrotics) or untreated (did not receive approved antifibrotics, but may have received other unapproved therapies). Classification of IPF diagnosis (confirmed/suspected) and severity ('mild'/'moderate'/'severe') for each patient was based on the individual physician's report. Patients' perspectives were not recorded in this study. Results: In total, 290 physicians responded to the questionnaire. Overall, 54% of patients with IPF did not receive treatment with an approved antifibrotic. More patients had a confirmed IPF diagnosis in the treated (84%) versus the untreated (51%) population. Of patients with a confirmed diagnosis, 40% did not receive treatment. The treated population was younger than the untreated population (67 vs 70 years, respectively; p = 0.01), with more frequent multidisciplinary team evaluation (83% vs 57%, respectively; p = 0.01). A higher proportion of untreated patients had forced vital capacity > 80% at diagnosis versus treated patients. Of patients with 'mild' IPF, 71% did not receive an approved antifibrotic versus 41% and 60% of patients with 'moderate' and 'severe' IPF, respectively. Conclusions: Despite the availability of antifibrotic therapies, many European patients with confirmed IPF do not receive approved antifibrotic treatment. Importantly, there appears to be a reluctance to treat patients with 'mild' or 'stable' disease, and instead adopt a 'watch and wait' approach. More education is required to address diagnostic uncertainty, poor understanding of IPF and its treatments, and issues of treatment access. There is a need to increase physician awareness of the benefits associated with antifibrotic treatment across the spectrum of IPF severity.
ISSN: 1471-2466

hal-01616061
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01616061
DOI : 10.1186/s12890-017-0468-5
PUBMED : 28915874

Éditeur(s) : Pergamon-elsevier Science Ltd
Résumé : Society's needs for a network of in situ ocean observing systems cross many areas of earth and marine science. Here we review the science themes that benefit from data supplied from ocean observatories. Understanding from existing studies is fragmented to the extent that it lacks the coherent long-term monitoring needed to address questions at the scales essential to understand climate change and improve geo-hazard early warning. Data sets from the deep sea are particularly rare with long-term data available from only a few locations worldwide. These science areas have impacts on societal health and well-being and our awareness of ocean function in a shifting climate. Substantial efforts are underway to realise a network of open-ocean observatories around European Seas that will operate over multiple decades. Some systems are already collecting high-resolution data from surface, water column, seafloor, and sub-seafloor sensors linked to shore by satellite or cable connection in real or near-real time, along with samples and other data collected in a delayed mode. We expect that such observatories will contribute to answering major ocean science questions including: How can monitoring of factors such as seismic activity, pore fluid chemistry and pressure, and gas hydrate stability improve seismic, slope failure, and tsunami warning? What aspects of physical oceanography, biogeochemical cycling, and ecosystems will be most sensitive to climatic and anthropogenic change? What are natural versus anthropogenic changes? Most fundamentally, how are marine processes that occur at differing scales related? The development of ocean observatories provides a substantial opportunity for ocean science to evolve in Europe. Here we also describe some basic attributes of network design. Observatory networks provide the means to coordinate and integrate the collection of standardised data capable of bridging measurement scales across a dispersed area in European Seas adding needed certainty to estimates of future oceanic conditions. Observatory data can be analysed along with other data such as those from satellites, drifting floats, autonomous underwater vehicles, model analysis, and the known distribution and abundances of marine fauna in order to address some of the questions posed above. Standardised methods for information management are also becoming established to ensure better accessibility and traceability of these data sets and ultimately to increase their use for societal benefit. The connection of ocean observatory effort into larger frameworks including the Global Earth Observation System of Systems (GEOSS) and the Global Monitoring of Environment and Security (GMES) is integral to its success. It is in a greater integrated framework that the full potential of the component systems will be realised. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
Progress In Oceanography (0079-6611) (Pergamon-elsevier Science Ltd), 2011-10 , Vol. 91 , N. 1 , P. 1-33

Droits : 2011 Published by Elsevier Ltd. All rights reserved.
http://archimer.ifremer.fr/doc/00044/15557/15923.pdf
DOI:10.1016/j.pocean.2011.05.001
http://archimer.ifremer.fr/doc/00044/15557/

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : L’Asie insulaire, forte exportatrice de main-d’œuvre féminine possède-t-elle un système migratoire propre ? Les cas indonésien, philippin et sri-lankais.Les migrations de travail ont une longue tradition en Asie. Instaurées par les puissances coloniales européennes par le biais des contrats de travail, après l’abolition de l’esclavage, elles ont ainsi favorisé l’expansion de deux solides diasporas, l’une chinoise, l’autre indienne.Ce vaste continent qui abrite désormais 60 % de la population mondiale et les deux tiers de la force de travail mondiale demeure, pour longtemps encore, une zone de très forte mobilité.Trois pays, dont deux archipels et une île, les Philippines, l’Indonésie et le Sri Lanka, sont devenus, en l’espace d’une à trois décennies, les principaux exportateurs de main-d’œuvre à l’échelle mondiale. Ces politiques migratoires visent d’une part à réduire la pauvreté et le chômage et d’autre part à accroître les indispensables rentrées de devises par le biais des transferts financiers des migrants. La féminisation des flux migratoires est particulièrement marquée en Asie insulaire où la proportion de femmes avoisine les 70 % du total des migrants.
The labour migration have a long tradition in Asia. Migration, which were introduced by European colonial powers (through employment contracts, after the abolition of slavery), have encouraged the expansion of two solid diasporas, 'One China, one Indian. This vast continent, home now 60% of the world's population and two thirds of the global labor force, remains for a long time, a zone of very high mobility. Three countries, including two archipelagos and one island, the Philippines, Indonesia and Sri Lanka are now in the space of one to three decades, the main exporters of labour globally. The objective of these policies migration is a part of reducing poverty and unemployment, and secondly to increase the necessary cash currency, with financial transfers of migrants. The feminization of migration is particularly marked in Asia island where the proportion of women is around 70% of total migrants
Indonésie
Philippines
Sri Lanka

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.982
http://journals.openedition.org/etudescaribeennes/982

Résumé : Bycatch of marine turtles, vulnerable or endangered species, is a growing issue of all fisheries, including Oceanic purse-seine fishery. The present paper seeks to assess marine turtle bycatch at a spatial and temporal level in the European purse seine fishery operating in the Atlantic and Indian Oceans. The study was based on data collected through French and Spanish observer programs from 1995 to 2011, a period where more than 230 000 fishing sets were realized by the UE fleets in both Oceans. A total of 15 913 fishing sets were observed, including 6 515 on drifting Fish Aggregate Devices (FAD) and 9 398 on Free Swimming Schools (FSC). Over the study period, 597 turtles were caught, 86% being released alive at sea. At the same time, from 2003 to 2011, 14 124 specific observations were carried out on floating objects whether they ended in a set or not. 354 marine turtles were observed upon which 80% were already free or entangled alive and therefore released alive. At the temporal and spatial level, data were organized and analysed by Ocean, fishing mode (FAD vs. FSC) as well as by year, quarter and statistical square of 1°. In order to evaluate the impact if this fishery in both Oceans, bycatch distribution was compared to the total fishing effort of the UE fleet, as well as to the known marine turtle post nesting migration routes, nesting population abundances and known feeding areas. The species composition, the size and sex structure of bycatch are also discussed here. At last, an attempt to raise the data to the total fishing effort was carried out. Based on observation of marine turtle by-catches on sets, we estimated that, globally, 3500 marine turtles were accidentally captured by the EU-PS fleet in the Atlantic Ocean from 1995 to 2010, and around 2000 in the Indian Ocean from 2003 to 2010, with a corresponding annual bycatch rate of 218 (SD=150; survival rate =91%) and 250 (SD=157; survival rate =77%) respectively in the Atlantic and Indian Ocean. However, because of important uncertainties mainly due to the low observation coverage and the scarcity of marine turtle bycatch events, it was impossible to produce solid and reliable global estimates of marine turtle bycatch and mortality due to PS activity.

Droits : 2012 IOTC
http://archimer.ifremer.fr/doc/00149/25991/24087.pdf
http://archimer.ifremer.fr/doc/00149/25991/

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : L’Union européenne opère actuellement la seconde révision de sa politique de la pêche depuis la création de celle-ci, en 1970. Instituée pour développer la pêche maritime et garantir un revenu aux pêcheurs, la politique commune de la pêche (PCP) s’est orientée progressivement vers la protection des espèces et de l’environnement marin. Pour cela, elle a sacrifié une part importante du secteur productif, mais a échoué et, avec le déclin de la pêche en Europe, les régions ultrapériphériques de la Caraïbe (RUP-C) ont gagné en importance relative dans ce domaine. Elles représentent aujourd’hui près de 30 % de la flotte nationale et les fondements malthusiens de la PCP ne sont plus adaptés à leurs caractéristiques : ressources halieutiques, développement économique, emplois, sécurité des approvisionnements alimentaires, etc. La réforme actuellement en cours, qui devrait aboutir avant 2012, offre peut-être une alternative aux RUP-C permettant la mise en œuvre des mesures spécifiques en application de l’article 349 du Traité sur le Fonctionnement de l’Union européenne.
The European Union currently operates the second reform of its Common Fisheries Policy since its creation in 1970. Established to develop the fisheries and provide incomes for fishermen, the Common Fisheries Policy (CFP) was directed gradually towards the protection of the species and the marine environment. To do this, it sacrificed a large part of the productive sector, but failed, and with the decline of fisheries in Europe, the outermost regions of the Caribbean gained relative importance in this field. They now account for nearly 30% of the national fleet and the Malthusians bases of the CFP are not suited any more to their characteristics: fisheries resources, economic development, jobs, security of food supply, etc. The ongoing reform, which should be in force before 2012, may offer an alternative to the outermost regions of the Caribbean for the implementation of specific measures under Article 349 of the Treaty on the Functioning of the European Union.
Caraïbes
Europe

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.4356
http://journals.openedition.org/etudescaribeennes/4356

Résumé : The MEDECO Leg 2 cruise followed the MEDECO Leg 1 cruise that had crossed the Mediterranean Sea from the west to the east to study benthic communities of the Var canyon, deep corals found on the Calabrian Margin and cold seep ecosystems of the Mediterranean Ridge. The main objective of the MEDECO Leg 2 cruise was to study and compare, using a multidisciplinary approach, the structure and dynamics of deep-sea ecosystems at various active cold seep sites from the Nile deep sea fan and the Calabrian Arc, in the Eastern Mediterranean sea. During MEDECO Legs 1 & 2, a multiscale strategy was promoted to integrate (1) a high resolution cartography of geological structures (km2 scale), (2) a detailed mapping, including video imagery, of smaller-scale areas (scale 100 to 300 m2), (3) the physical, chemical and sedimentary characteristics of the habitat (multiscale), (4) the structure and functioning of faunal communities, including microbes, in terms of composition, diversity and biomass (multiscale), (5) small scale studies of interactions between organisms and their environment (scale < m2), (6) detailed ecophysiological studies at the organism scale on invertebrates. The use of the ROV “Victor 6000” and of various equipments for in situ and ex situ observations and measurements has helped reaching our objectives. The MEDECO cruise represented the key-Mediterranean cruise of the HERMES project “Hotspot Ecosystem Research on the Margins of European Seas” (P.I. P. Weaver, NOC-Southampton). The cruise was organized to follow the objectives of the HERMES program to better understand the functioning of deep ecosystems of the continental margins aiming at obtaining: (1) the description and quantification of the natural drivers (geological, hydrological, chemical factors) that control the distribution of ecosystems on margins; (2) the characterization and quantification of biodiversity, from bacteria to megafauna, as well as the knowledge of ecosystem functioning; (3) the study of ecosystems dynamics including the biology/physiology of key-species. Specific objectives. Colonization experiments conducted in the frame of two European programs, Diwoo and Chemeco, have given the opportunity to recover the fauna installed in the devices deployed during the Bionil cruise (2006) and to deploy new ones at the same site located in the pockmark area of the central province of Nile deep sea fan.

Droits : 2008 Insu, Cnrs, Locean
http://archimer.ifremer.fr/doc/00134/24550/22583.pdf
http://archimer.ifremer.fr/doc/00134/24550/

Éditeur(s) : HAL CCSD
Résumé : International audience
The geology of the North Pyrenean Zone in the central Pyrenees allows for the observation in the field of theentire section of the Pyrenean rift, from the mantle to the crust and the Mesozoic cover (pre, syn and post rift).The good knowledge we have of the pre-Alpine history of the Pyrenees allows us to properly constrain the Alpinegeological evolution of the pre-Triassic rocks which record both Variscan and Alpine orogenic cycles.The mantle outcrop as kilometric to centimetric fragments of peridotite dispersed within a carbonate metamorphicbreccia. The study of peridotite serpentinisation shows several events of low-temperature serpentinisation, incontact with seawater. In some locallities, we can observe a mixture of fragments of variously serpentinizedperidotites. This suggests a tectonic context where fragments of peridotites from different structural levels weresampled more or less synchronously.The granulitic basement is characterized by a Variscan syndeformational HT event (300-280 Ma). So farwe have not found any trace of a Cretaceous HT event (> 500C). On the other hand, the basement is affectedby a regional metasomatism that began during the Jurassic and became more spatially focused with time until itwas restricted to the Pyrenean rift during the Aptien, Albian and Cenomanian. The talc-chlorite metasomatism(120-95 Ma) shows an evolution from a static toward a syn-deformation hydrothermal event, under a more or lessnormal geothermal gradient. Extensional deformation is recorded by the reworking of several inherited low-angleVariscan tectonic contacts, but also by dispersed high-angle extensional shear zones formed under greenshistconditions.The metamorphic Mesozoic cover of the basement massifs, which constitute the so-called Internal MetamorphicZone, is an allochtonous unit made of lenses of Mesozoic rocks enclosed into the breccia, whichlocally contains peridotite and basement clasts. The Mesozoic metamorphic carbonates show a first phase ofsyn-metamorphic (450-600C, P < 2 kb) ductile deformation, and subsequent phases of folding and fracturing.The datation of neoformed minerals give a 108-85 Ma time span for the metamorphism. We interpret this brecciaas an abandonment breccia which marks the emergence of the main detachment. The basal contact of the Mesozoiccover has a complex 3D geometry traced by Triassic evaporites. It corresponds to a major pre- and synorogenicpolyphased tectonic contact.All these data show a geometrically complex hyper-extended rift where the crust was not stretched under ahigh geothermal gradient but thinned by the tectonic extraction of relatively thin lenses and perhaps cut by highangle low-grade shear zones. The 3D geometry, as well as the strain records and the breccia lithologies stronglysuggest a non-cylindricity for the exhumation process, probably within a transtentional system
Geophysical Research Abstracts
Vienne, Austria

insu-01510371
https://hal-insu.archives-ouvertes.fr/insu-01510371

Résumé : Depuis 1999, l’Union européenne a inauguré une nouvelle approche dans ses relations avec l’Amérique latine et les Caraïbes. A cet égard, le premier sommet Union européenne – Amérique latine – Caraïbes, dit « sommet de Rio » marque un tournant grâce au lancement du « partenariat stratégique ». Dans ce cadre, toutes les organisations régionales d’intégration économique situées dans cette zone géographique, et non pas uniquement le MERCOSUR, apparaissent comme des partenaires importants. Le changement obéit autant à des contraintes externes qu’à une stratégie extérieure. Dans le domaine des échanges commerciaux, le but déclaré est d’atteindre « une libéralisation mutuelle des échanges » sur une base équitable et mutuellement profitable tout en défendant certaines valeurs communes. Cependant, le cadre juridique longtemps en vigueur s’est avéré inadapté à l’avènement d’une ambition économique et politique d’une telle ampleur. Par conséquent, l’Union européenne se trouve confrontée au défi de réformer les cadres juridiques de ses relations avec les organisations régionales d’intégration économique d’Amérique latine et des Caraïbes. La thèse analyse l’évolution et la restructuration actuelles des instruments juridiques des relations entre l’Union européenne l’Amérique latine et les Caraïbes.
Since 1999, the European Union began a new competitive approach in its relationships with Latin America and the Caribbean. In this respect, the first step has been made in the European Union-Latin America and Caribbean’ Summit [Rio Summit (1999)] with the launch of a new partnership called “Strategic Partnership”. In this context, all organisations of regional economic integration – not only the MERCOSUR the most competitive one – are considered as important partners. The change is due to external constraints as well as an external strategy. In the field of commercial exchanges, the goal is to attempt “mutual liberalisation of exchanges” on a fair and mutually profitable basis, defending at the same time “common values”. However, the traditional legal framework of the relations is obviously unsuitable for such an ambitious economic and political project. So, from a legal aspect, the European Union is confronted with the challenge of reforming the contractual frameworks of its relations with regional economic integrations in Latin America and in the Caribbean. The issue concerns an analysis of the evolution and restructuring of existing legal instruments of the European Union’s relations with Latin America and the Caribbean.
Desde 1999, la Unión Europea instauró un nuevo enfoque en sus relaciones con América Latina y el Caribe. En este enfoque llamado “estratégico”, todas las organiza-ciones comarcales de integración económicas ubicadas en esta zona geográfica y no úni-camente el MERCOSUR, se pueden ver como interlocutores importantes. La primera cumbre Unión Europea /América latina/Caribe (cumbre de Rio) es una fecha importante en la evolución de las relaciones gracias al lanzamiento “de la colaboración estratégica”. En lo que toca a los intercambios comerciales, la meta declarada es alcanzar una “liberalización mutual de los intercambios” a partir de una base equitativa y mutualmente provechosa de-fendiendo a la vez ciertos valores comunes. Sin embargo, el marco jurídico en vigor durante una larga temporada se ha reve-lado inadecuado para el advenimiento de una ambición económica y política de esta impor-tancia. Por consiguiente, la Unión Europea se enfrenta hoy en día al desafío jurídico de la renovación del marco convencional de sus relaciones con las organizaciones de integración económica de América Latina y del Caribe. El asunto se refiere a un análisis de las rela-ciones exteriores de la Unión Europea desde el punto de vista de los desafíos jurídicos. Utilizamos el análisis sistémico para poner de relieve los factores explicativos de la evolu-ción y de la reestructuración actuales de los instrumentos jurídicos de las relaciones entre la Unión Europea y América-Latina Caribe.

http://www.theses.fr/2011AGUY0495/document

Éditeur(s) : Elsevier
Résumé : High-resolution sedimentological and micropaleontological studies of several deep-sea cores retrieved from the levees of the Celtic and Armorican turbidite systems (Bay of Biscay - North Atlantic Ocean) allow the detection of the major oscillations of the British-Irish Ice Sheet (BIIS) and 'Fleuve Manche' palaeoriver discharges over the last 30,000 years, which were mainly triggered by climate changes. Between 30 and 20 cal ka, the turbiditic activity on the Celtic-Annorican margin was weak, contrasting with previous stratigraphic models which predicted a substantial increase of sediment supply during low sea-level stands. This low turbidite deposit frequency was most likely the result of a weak activity of the 'Fleuve Manche' palaeoriver and/or of a reduced seaward transfer of sediments from the shelf to the margin. However, two episodes of turbiditic activity increase were detected in the Celtic-Armorican margin, during Heinrich events (HE) 3 and 2. This strengthening of the turbiditic activity was triggered by the meltwater releases from European ice sheets and glaciers favouring the seaward transfer of subglacial material, at least via 'Fleuve Manche' palaeoriver. At around 20 cal ka, a significant increase of turbidite deposit frequency occurred as a response to the onset of the last deglaciation. The retreat of the European ice sheets and glaciers induced a substantial increase of the 'Fleuve Manche' palaeoriver discharges and seaward transfer of continentally-derived material into the Armorican turbidite system. The intensification of the turbiditic activity on the Celtic system was directly sustained by the widespread transport of subglacial sediments from the British-Irish Ice Sheet (BIIS) to the Celtic Sea via the Irish Sea Basin. A sudden reduction of turbiditic activity in the Armorican system, between ca. 19 and 18.3 cal ka, could have been triggered by the first well known abrupt sea-level rise ('meltwater pulse', at around 19 cal ka) favouring the trapping of sediment in the 'Fleuve Manche' palaeoriver valleys and the decrease of the seaward transfer of continentally-derived material. The maximum of turbiditic activity strengthening in the Celtic-Armorican margin, between ca. 18.3 and 17 cal ka, was induced by the decay of European ice sheets and glaciers producing the most extreme episode of the 'Fleuve Manche' palaeoriver runoff and a great seaward transfer of subglacial material into the Bay of Biscay, Between ca. 17.5 and 16 cal ka, the turbiditic activity significantly decreased in both Celtic and Armorican turbidite systems in response to a global re-advance of glaciers and ice sheets in Europe. The last episode of ice sheet retreat, between ca. 16 and 14 cal ka, is well expressed in the Celtic system by a new increase of the turbiditic activity. The major episode of sea-level rise at around 14 cal ka ('Meltwater Pulse 1A'), precluding the seaward transfer of sediments, induced the end of turbiditic activity in both the Celtic and the Armorican system. Although two main phases of global sea-level rise seem to have had an effect on the Celtic-Armorican margin, this work proposes the BUS retreat and associated riverine discharges as the main trigger mechanisms of the turbiditic activity in this region during the last 30,000 years.
Marine Geology (0025-3227) (Elsevier), 2008 , Vol. 247 , N. 1-2 , P. 84-103

Droits : 2008 Elsevier B.V. All rights reserved
http://archimer.ifremer.fr/doc/2008/publication-3729.pdf
DOI:10.1016/j.margeo.2007.08.006
http://archimer.ifremer.fr/doc/00000/3729/

Résumé : This report synthesises the knowledge on the biogeochemical cycle, bioconcentration processes and ecotoxicity of lead in the marine environment. Man induced changes on the lead cycle, especially along the French coasts are reviewed. Concentration levels, mechanisms and fluxes between geochemical reservoirs are assessed. Emphasis is given on sublethal effects and toxicity mechanisms. Quality standards used in European Community countries are listed. Conclusions and recommendations for environmental management and research are given.
Le présent document constitue une synthèse des connaissances sur le cycle biogéochimique, la bioconcentration et l'écotoxicité du plomb en milieu marin. Il fait état des perturbations du cycle du plomb par l'action de l'homme, en particulier dans le milieu littoral français. Les niveaux de concentration et les quantités échangées entre les réservoirs géochimiques sont évalués. L'accent est mis sur les effets sublétaux et les mécanismes de toxicité vis-à-vis du biotope marin. Les réglementations relatives en milieu marin actuellement en vigueur dans les pays de la Communauté européenne sont répertoriées. Avec les conclusions quelques recommandations en matière de gestion et de recherche sont faites.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/1993/rapport-1449.pdf
http://archimer.ifremer.fr/doc/00000/1449/

Résumé : This report includes a qualitative and descriptive approach of the oyster and mussel industries in the European Community. This report compares the structure of production, the marketsn the professional organisation, competition for the resource, legislation and support systemat the community levell. Technical and statistical datas are summarized to représent the structure of the industry, the trade flows and the main evolutions of the two industries in the EC. A summary of the county reports gives an overview of the present state of the industry in each country and suggest a first evaluation of constraints and prospects. [NOT CONTROLLDED OCR]
Ce rapport comprend une approche descriptive et qualitative du secteur conchylicole traditionnel (moules et huîtres) dans la Communauté Européenne. Il aborde les aspects production, marché, organisation, réglementation, système d'aide dans les différents pays par une analyse comparative des secteurs, complétée par une synthèse chiffrée des données techniques et statistiques. Une vision d'ensemble des flux et de l'évolution des deux filières dans la Communauté est ainsi présentée. Un résumé des rapports nationaux évalue l'organisation, les contraintes et les perspectives du secteur dans chacun des pays. [OCR NON CONTRÔLE]

Droits : 1993 Ifremer
http://archimer.ifremer.fr/doc/1993/rapport-4176.pdf
http://archimer.ifremer.fr/doc/1993/sup-4176.pdf
http://archimer.ifremer.fr/doc/00000/4176/

Éditeur(s) : HAL CCSD MDPI
Résumé : International audience
The issue of drinking water quality compliance in small and medium scale water services is of paramount importance in relation to the 98/83/CE European Drinking Water Directive (DWD). Additionally, concerns are being expressed over the implementation of the DWD with respect to possible impacts on water quality from forecast changes in European climate with global warming and further anticipated reductions in north European acid emissions. Consequently, we have developed a decision support system (DSS) named ARTEM-WQ (AwaReness Tool for the Evaluation and Mitigation of drinking Water Quality issues resulting from environmental changes) to support decision making by small and medium plant operators and other water stakeholders. ARTEM-WQ is based on a sequential risk analysis approach that includes consideration of catchment characteristics, climatic conditions and treatment operations. It provides a holistic evaluation of the water system, while also assessing human health risks of organic contaminants potentially present in treated waters (steroids, pharmaceuticals, pesticides, bisphenol-a, polychlorobiphenyls, polycyclic aromatic hydrocarbons, petrochemical hydrocarbons and disinfection by-products; n = 109). Moreover, the system provides recommendations for improvement while supporting decision making in its widest context. The tool has been tested on various European catchments and shows a promising potential to inform water managers of risks and appropriate mitigative actions. Further improvements should include toxicological knowledge advancement, environmental background pollutant concentrations and the assessment of the impact of distribution systems on water quality variation.
ISSN: 1660-4601

hal-01122233
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01122233
PUBMED : 25046634
DOI : 10.3390/ijerph110707354
PUBMEDCENTRAL : PMC4113881

Éditeur(s) : HAL CCSD
Résumé : International audience
BACKGROUND: Persistent organic pollutants may affect the immune and respiratory systems, but available evidence is based on small study populations. We studied the association between prenatal exposure to dichlorodiphenyldichloroethylene (DDE) and polychlorinated biphenyl 153 (PCB 153) and children's respiratory health in European birth cohorts. METHODS: We included 4608 mothers and children enrolled in 10 birth cohort studies from 7 European countries. Outcomes were parent-reported bronchitis and wheeze in the first 4 years of life. For each cohort, we performed Poisson regression analyses, modeling occurrences of the outcomes on the estimates of cord-serum concentrations of PCB 153 and DDE as continuous variables (per doubling exposure) and as cohort-specific tertiles. Summary estimates were obtained through random-effects meta-analyses. RESULTS: The risk of bronchitis or wheeze (combined variable) assessed before 18 months of age increased with increasing DDE exposure (relative risk [RR] per doubling exposure = 1.03 [95% confidence interval = 1.00-1.07]). When these outcomes were analyzed separately, associations appeared stronger for bronchitis. We also found an association between increasing PCB 153 exposure and bronchitis in this period (RR per doubling exposure = 1.06 [1.01-1.12]) but not between PCB 153 and wheeze. No associations were found between either DDE or PCB 153 and ever-wheeze assessed after 18 months. Inclusion of both compounds in the models attenuated risk estimates for PCB 153 tertiles of exposure, whereas DDE associations were more robust. CONCLUSION: This large meta-analysis suggests that prenatal DDE exposure may be associated with respiratory health symptoms in young children (below 18 months), whereas prenatal PCB 153 levels were not associated with such symptoms.
Epidemiology (Cambridge, Mass.)

hal-01063930
https://hal.archives-ouvertes.fr/hal-01063930
DOI : 10.1097/EDE.0000000000000097
PUBMED : 24776790

Éditeur(s) : HAL CCSD Taylor & Francis (Routledge)
Résumé : International audience
The French Antilles (Martinique, Saint Martin and Guadeloupe) and French Guiana are the French territories most affected by the HIV epidemic. Some population groups such as men who have sex with men (MSM), especially those involved in transactional sex, are thought to be particularly vulnerable to HIV but few data exist to help characterize their health-related needs and thus implement relevant prevention interventions. To fill this knowledge gap, we used data collected from an HIV/AIDS Knowledge, Attitudes, Behaviours and Practices survey conducted in 2012 among MSM living in the French Antilles and French Guiana and recruited through snowball sampling. Our objectives were to compare social and demographic characteristics and sexual behaviours between MSM engaging in transactional sex and MSM not engaging in transactional sex and to identify factors associated with transactional sex involvement using a logistic regression model. A total of 733 MSM were interviewed, 21% of whom reported to undergo transactional sex. Their behaviour and social and demographic characteristics were different from other MSMs’ and they were more exposed to factors that are recognized to potentiate HIVvulnerability, at the individual, community, network and structural levels. The variables positively associated with sex trade involvement were having ever consumed drug (OR = 2.84 [1.23–6.52]; p = .002), having a greater number of sex partners than the median (OR = 8.31 [4.84–14.30]; p < .001), having experienced intimate partner violence (OR = 1.72 [0.99–3.00]; p = .053) and having undergone physical aggression because of sexual orientation (OR = 2.84 [1.23–6.52];p = .014). Variables negatively associated with sex trade involvement were being older (OR = 0.93 [0.90–0.97] per year; p = .001), having a stable administrative situation (OR = 0.10 [0.06–0.19]; p < .001), having a stable housing (OR = 0.29 [0.15–0.55]; p < .001) and being employed full-time (OR = 0.29 [1.23–6.52]; p = .002).
ISSN: 0954-0121

inserm-01407263
http://www.hal.inserm.fr/inserm-01407263
http://www.hal.inserm.fr/inserm-01407263/document
http://www.hal.inserm.fr/inserm-01407263/file/AIDS%20Care%20final%20version.pdf
DOI : 10.1080/09540121.2016.1234680

Éditeur(s) : IEEE
Résumé : It is now well understood that data on soil moisture and sea surface salinity (SSS) are required to improve meteorological and climate predictions. These two quantities are not yet available globally or with adequate temporal or spatial sampling. It is recognized that a spaceborne L-band radiometer with a suitable antenna is the most promising way of fulfilling this gap. With these scientific objectives and technical solution at the heart of a proposed mission concept the European Space Agency (ESA) selected the Soil Moisture and Ocean Salinity (SMOS) mission as its second Earth Explorer Opportunity Mission. The development of the SMOS mission was led by ESA in collaboration with the Centre National d'Etudes Spatiales (CNES) in France and the Centro para el Desarrollo Tecnologico Industrial (CDTI) in Spain. SMOS carries a single payload, an L-Band 2-D interferometric radiometer operating in the 1400-1427-MHz protected band [1]. The instrument receives the radiation emitted from Earth's surface, which can then be related to the moisture content in the first few centimeters of soil over land, and to salinity in the surface waters of the oceans. SMOS will achieve an unprecedented maximum spatial resolution of 50 km at L-band over land (43 km on average over the field of view), providing multiangular dual polarized (or fully polarized) brightness temperatures over the globe. SMOS has a revisit time of less than 3 days so as to retrieve soil moisture and ocean salinity data, meeting the mission's science objectives. The caveat in relation to its sampling requirements is that SMOS will have a somewhat reduced sensitivity when compared to conventional radiometers. The SMOS satellite was launched successfully on November 2, 2009.
Proceedings of the IEEE (0018-9219) (IEEE), 2010-05 , Vol. 98 , N. 5 , P. 666-687

Droits : 2010 IEEE – All Rights Reserved
http://archimer.ifremer.fr/doc/00004/11483/8065.pdf
DOI:10.1109/JPROC.2010.2043032
http://archimer.ifremer.fr/doc/00004/11483/

Éditeur(s) : Elsevier Science Bv
Résumé : Small-scale fisheries have traditionally received less research effort than large-scale fisheries and are generally under-studied in Europe. In spite of their comparatively low volume of catches and economic importance, small-scale fisheries are socially important and an integral part of the European coastal zone. Considering the high heterogeneity of situations and the paucity of quantitative data, we used an analytical methodology based on the comparative method. We carried out an analysis of small-scale fisheries (SSFs) in Europe based on a selection of nine case studies. Our objective was to obtain a comprehensive description of small-scale fleets covering different areas/fisheries/species, encompassing the diversity and specific conditions under which SSFs operate, in order to demonstrate the ecological and social sustainability of this often overlooked fisheries segment. A common approach formulated so that the case studies could be compared with the case histories of other competing users, required that for each set of criteria – technical, biological, socio-economic, and institutional – a set of relevant items and indicators was established. An analysis of characteristics common to the selected case studies is conducted and an attempt made to extend our comparisons to the whole of the European Union. Our results show that (as compared with large-scale fleets, their main competitor) small-scale fleets: (i) are composed of smaller vessels and, consequently, travel lower distances to fishing grounds, and are more reliant on coastal areas; (ii) have smaller crews (although the global employment figure is similar to that of large-scale fleets in Europe); (iii) use mostly, but not exclusively, passive gears; (iv) use multi-purpose fishing approaches, and can change the fish species they target during the year; (v) have lower extraction rates; (vi) have lower total capital investments (including fishing rights), turnover and costs; and (vii) have lower fuel consumption, making them less sensitive to changing oil prices. Dependence on subsidies is lower (viii). Involvement in fisheries management is variable, conservation and access regulation measures are largely local in origin. For the selected case studies, the most significant competitors are large-scale fleets, and recreational fisheries, but other sources of interaction (water quality, invasive species, etc.) cannot be ignored.
Fisheries Research (0165-7836) (Elsevier Science Bv), 2013-02 , Vol. 140 , P. 1-13

Droits : 2012 Elsevier B.V. All rights reserved
http://archimer.ifremer.fr/doc/00118/22934/20757.pdf
DOI:10.1016/j.fishres.2012.11.008
http://archimer.ifremer.fr/doc/00118/22934/

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : El desarrollo del turismo de masas en Canarias se inició a principios de la década de los años sesenta del siglo XX. El modelo adoptado fue coetáneo y muy semejante al de otras zonas litorales del Estado español, que se vieron afectadas por un intenso proceso de urbanización. Acutalmente, el perfil del turismo que nos visita nos indica la preferencia de los centroeuropeos por este destino, predominantemente, de los alemanes y británicos. En cuanto a la oferta turística, la política de los tour-operadores, los factores medio-ambientales y patrimoniales, así como el apoyo de las instituciones y de los empresarios han sido decisivos. Por ello, este sector se ha convertido en el motor de la economía del Archipiélago.
Le développement du tourisme de masses dans les Îles Canaries a commencé au début des années 1960. Le modèle adopté repose sur les mêmes logiques que les aménagements touristiques des littoraux méditerranéens espagnols qui ont abouti à d’intenses processus d’urbanisation. Actuellement, la fréquentation touristique de l’archipel indique la préférence des clientèles de l’Ouest-européen, surtout des allemandes et britanniques. Le tourisme s’est affirmé comme le véritable moteur de l’économie de l’archipel.
The development of mass tourism in the Canary Islands started in middle of the 20th century, at the beginning of the 60’s. The adopted model was contemporary and very similar to the model of other coastal areas of the Spanish State, which were affected by an intense urbanization process. Nowadays, the profile of the tourism that visits us shows the preference of Centre-European citizens for this destiny, predominately German and British. As regards the tourist offer, the tour-operators policy, the environmental and patrimonial factors, as well as the institutional and managerial support have been definitive. That’s why this sector has become the motor of the archipelago’s economy.
Canaries

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.1082
http://journals.openedition.org/etudescaribeennes/1082

Éditeur(s) : HAL CCSD
Résumé : International audience
BACKGROUND AND AIM: The impact of basal core promoter (BCP) and precore (PC) mutants of the hepatitis B virus (HBV) on liver disease severity remains controversial. The aim of the present study was to screen BCP and PC mutations in 252 HBV surface antigen (HBsAg) positive carriers in France and to assess relationships between these mutations and severe fibrosis. METHODS: Direct sequencing of the precore/core gene was used to detect A1762T/G1764A and G1757A mutations in the BCP and G1896A and G1899A mutations in the PC region. RESULTS: The prevalences of A1762T/G1764A, G1757A, G1896A, and G1899A mutations were 34.1%, 38.7%, 54.9%, and 29.3% (P < 0.001), respectively. The independent predictors of severe fibrosis (>/=F3 Metavir) were older age (P < 0.001), male gender (P = 0.012), elevated alanine aminotransferase (P < 0.001), and the double A1762T/G1764A mutant with no other mutations (P = 0.011). Interestingly, the association of the G1899A mutation with the double A1762T/G1764A mutant significantly counteracted the deleterious effect of the sole double A1762T/G1764A mutant (odds ratio [OR] = 0.28 vs. OR = 3.55, respectively, P = 0.028). CONCLUSIONS: Patients with the A1762T/G1764A mutation have a higher risk of severe fibrosis. The G1899A mutation is a protective factor against severe fibrosis that counteracted the deleterious effect of the A1762T/G1764A mutation. Finally, host phenotypic and HBV genotypic markers independently predict fibrosis severity.
Journal of gastroenterology and hepatology

hal-01477209
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01477209
DOI : 10.1111/jgh.13338
PUBMED : 26992056

Éditeur(s) : HAL CCSD
Résumé : International audience
Coming from Crimea, the Black Death spread to Western Europe and North Africa during the 1340s. From 1346 to 1352, the plague killed an estimated 25-40% of Europeans of all age-groups [1] , i.e., 30 to 60% of Europe population. One of the earliest and most widely accepted explanations was that God was punishing humanity for their sins. One remedy for the curse was to do penitence. Thus in 1348 there rapidly arose a mass movement of flagellation [2]. In fact flagellation could not really help against such threat. The Black Death or Bubonic plague is caused by Yersinia pestis, a Eubacteria discovered in 1894 by Alexandre Yersin. It is transmitted by the bite of the flea Xenopsylla cheopsis. This flea lives by feeding the blood of many species besides man but its most preferred relationship is with the black rat (Rattus rattus). Fossilized remains of the plague flea have been found in large numbers in Amarna, Egypt [3, 4] about 1350 BC, and thus could be directly linked to the events described in the Book of Samuel [5, 6]. During the epidemic of Bubonic plague in London in 1665-1666, the known treatments were made use of, e.g. the so-famous Theriac or Venice Treacle which is used from the time of ancient Rome as a remedy against poison [7]. Since then, more specialized and novel treatments have been developed. However, since the characterization of Yersinia pestis, numerous drugs have been developed against it, e.g. gentamicin or doxycycline [8]. These researches had been carried out using more elaborated biochemical, biophysical and biological approaches.
Infectious disorders drug targets

Droits : info:eu-repo/semantics/OpenAccess
inserm-00395256
http://www.hal.inserm.fr/inserm-00395256
http://www.hal.inserm.fr/inserm-00395256/document
http://www.hal.inserm.fr/inserm-00395256/file/editorial.pdf
http://www.hal.inserm.fr/inserm-00395256/file/inserm-00395256_edited.pdf

Éditeur(s) : HAL CCSD
Résumé : International audience
Based on US national cancer registry data, age differences at breast cancer diagnosis have been reported between African-American women and European-American women. Such differences between populations of African and European ancestry have not been studied in other countries at a nationwide level. Here, we report and compare descriptive nationwide epidemiological indicators of invasive breast cancer for the populations of European ancestry living in the US and in mainland France and for women of African ancestry living in the US and in the French West Indies (Martinique and Guadeloupe). Based on the available data, we determined age frequency distributions, world age-standardized incidence, and the distribution of expected cases of breast cancer in a standard population of women by age. The age frequency distributions revealed that women of African ancestry were younger at diagnosis than women of European ancestry. By contrast, compared with the US regardless of ancestry and mainland France, the standardized incidences appeared lower, and the largest numbers of expected cases younger, in the French West Indies. The populations with African ancestry were not homogeneous in terms of epidemiologic indicators of age-related breast cancer. These descriptive findings suggest that populations of African ancestry cannot be considered uniform when determining whether it would be appropriate to decrease the age of entry into screening programs for breast cancer.
The Breast Journal

hal-01063922
https://hal.archives-ouvertes.fr/hal-01063922
DOI : 10.1111/tbj.12228
PUBMED : 24617611