Éditeur(s) : HAL CCSD BioScientifica
Résumé : International audience
BACKGROUND: Differences in circulating steroid hormone levels have been hypothesized to explain ethnic differences in steroid-related diseases. The aim of this study was to determine the serum levels of a wide panel of steroid hormones, both androgens and estrogens, in healthy middle-aged African-Caribbean and European men. DESIGN AND METHODS: Serum steroid hormone levels were determined in men participating in a systematic public health study funded by the French National Health Insurance system. Blood was collected in the morning from 304 healthy African-Caribbean and European men aged between 40 and 69 years. Serum steroids were measured by mass spectrometry-gas chromatography, except for DHEAS and sex hormone-binding globulin, which were determined by RIA. Data were analyzed in 10-year age intervals by analysis of covariance, with adjustment for age, body mass index, waist-to-hip ratio, tobacco and alcohol consumption, and season of sampling. RESULTS: Compared with Europeans, African-Caribbean men presented significantly higher serum levels of measured bioavailable testosterone, 4-androstenedione (4-dione), and estrone (E1) regardless of the age group, of 5-androstenediol (5-diol) in those aged 40-49 and 50-59 years, and of testosterone (TT) and dihydrotestosterone in those aged 40-49 years. In contrast, European men aged 40-69 years showed significantly higher serum levels of DHEA and DHEAS. CONCLUSIONS: Significant differences in serum steroid hormone levels were observed in middle-aged African-Caribbean and European men. Whether such differences could contribute to ethnic differences in disease risk in adult men remains to be investigated. Some steroids, such as bioavailable TT, 4-dione, 5-diol, and E1, deserve particular attention.
ISSN: 0804-4643

hal-00876034
https://hal.archives-ouvertes.fr/hal-00876034
DOI : 10.1530/EJE-11-0551
PUBMED : 21951700

Éditeur(s) : HAL CCSD
Résumé : poster presentation, 22nd European Meeting on Hypertension and Cardiovascular protection, London,26-29 April 2012
OBJECTIVE: Several studies demonstrate that the perception of overweight is associated with attempts at weight control in overweight subjects. Our objective is to describe the factors associated with the perception of overweight in an adult Caribbean population, and in particular, to assess the relationship between the perception of overweight and previous medical diagnosis of overweight. METHOD AND DESIGN: Consant was a cross-sectional study carried out in 2007 on a representative sample of the adult Guadeloupean population. Included were 1,005 subjects aged 25-74 years, drawn from stratified random sampling, and interviewed at home. The perception of overweight was evaluated by the question: "Do you consider yourself to be overweight?" with a binary response. RESULTS: Among overweight subjects (Body Mass Index ≥ 25 kg/m2, n = 576), 38.6% provided an incorrect assessment of their weight status. This proportion falls to 17.4% in those who stated to have previously received a medical diagnosis of overweight. However, only 48.8% of overweight subjects stated to have received such a diagnosis. A logistic regression shows that the underestimation of weight status is associated with the absence of previous diagnosis for overweight (OR: 5.35 - p < 10-3), as well as an age greater than or equal to 55 years (OR: 2.91 - p < 10-3), a BMI of less than 30 kg/m² (OR: 2.26 - p: 0.001), the male sex (OR: 1.86 - p: 0.004), and a low income level (OR: 1.62 - p: 0.030), but not a lack of awareness regarding the role of weight control in the prevention of cardiovascular diseases. Similar results are observed if waist circumference is taken as a factor instead of BMI. CONCLUSION: In this population, the lack of medical diagnosis of overweight was the leading factor associated with misperception of overweight. Screening for overweight therefore appears to be one of the preconditions to weight management, and remains a fundamental but often unused element in the fight against obesity.
https://hal.univ-antilles.fr/hal-00739785

Droits : info:eu-repo/semantics/OpenAccess
hal-00739785
https://hal.univ-antilles.fr/hal-00739785
https://hal.univ-antilles.fr/hal-00739785/document
https://hal.univ-antilles.fr/hal-00739785/file/The_lacksur screening_is_the_leading_factor_associated_with_the_misperceptionsur overweight_cor.pdf

Éditeur(s) : Elsevier
Résumé : The individual food-demand behavior of juvenile European sea bass (Dicentrarchus labrax, L.) reared in groups under self-feeding conditions was investigated. The triggering activity on self-feeder, i.e. index of the food-demand activity, agonistic interactions and territorial behavior were monitored for periods of 42 to 68 days in six groups of 50 fish. The specific growth rate was calculated and the brain serotonergic activity was used as a stable index of social stress. Inter-individual differences appeared in triggering activity and three groups were distinguished: 3-5 high-triggering fish, 17-30 low-triggering fish and the remaining individuals were null-triggering fish. There were no significant differences in specific growth rates calculated at the end of the experiment (day 42 or day 68) between individuals with high, low, and null food-demand (ANOVA, p > 0.05). No territorial or agonistic behaviors were observed, however, there were significant differences in brain scrotonergic activity between the three triggering groups (ANOVA, p=0.050 in telencephalon and p=0.004 in cerebellum). Specifically, high-triggering fish had lower serotonergic turnover than low or null-triggering fish. We put forth the hypothesis that fish with low or null-triggering activity could be stressed by the high activity of high-triggering individuals. (c) 2006 Elsevier Inc. All rights reserved.
Physiology & Behavior (0031-9384) (Elsevier), 2007-03 , Vol. 90 , N. 4 , P. 559-566

Droits : 2006 Elsevier Inc. All rights reserved
http://archimer.ifremer.fr/doc/2007/publication-2637.pdf
DOI:10.1016/j.physbeh.2006.11.005
http://archimer.ifremer.fr/doc/00000/2637/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
BACKGROUND: Thrombophilias are common disorders that increase the risk of pregnancy-associated venous thromboembolism and pregnancy loss and can also increase the risk of placenta-mediated pregnancy complications (severe pre-eclampsia, small-for-gestational-age infants, and placental abruption). We postulated that antepartum dalteparin would reduce these complications in pregnant women with thrombophilia. METHODS: In this open-label randomised trial undertaken in 36 tertiary care centres in five countries, we enrolled consenting pregnant women with thrombophilia at increased risk of venous thromboembolism or with previous placenta-mediated pregnancy complications. Eligible participants were randomly allocated in a 1:1 ratio to either antepartum prophylactic dose dalteparin (5000 international units once daily up to 20 weeks' gestation, and twice daily thereafter until at least 37 weeks' gestation) or to no antepartum dalteparin (control group). Randomisation was done by a web-based randomisation system, and was stratified by country and gestational age at randomisation day with a permuted block design (block sizes 4 and 8). At randomisation, site pharmacists (or delegates) received a randomisation number and treatment allocation (by fax and/or e-mail) from the central web randomisation system and then dispensed study drug to the local coordinator. Patients and study personnel were not masked to treatment assignment, but the outcome adjudicators were masked. The primary composite outcome was independently adjudicated severe or early-onset pre-eclampsia, small-for-gestational-age infant (birthweight <10th percentile), pregnancy loss, or venous thromboembolism. We did intention-to-treat and on-treatment analyses. This trial is registered with ClinicalTrials.gov, number NCT00967382, and with Current Controlled Trials, number ISRCTN87441504. FINDINGS: Between Feb 28, 2000, and Sept 14, 2012, 292 women consented to participate and were randomly assigned to the two groups. Three women were excluded after randomisation because of ineligibility (two in the antepartum dalteparin group and one in the control group), leaving 146 women assigned to antepartum dalteparin and 143 assigned to no antepartum dalteparin. Some patients crossed over to the other group during treatment, and therefore for on-treatment and safety analysis there were 143 patients in the dalteparin group and 141 in the no dalteparin group. Dalteparin did not reduce the incidence of the primary composite outcome in both intention-to-treat analysis (dalteparin 25/146 [17.1%; 95% CI 11.4-24.2%] vs no dalteparin 27/143 [18.9%; 95% CI 12.8-26.3%]; risk difference -1.8% [95% CI -10.6% to 7.1%)) and on-treatment analysis (dalteparin 28/143 [19.6%] vs no dalteparin 24/141 [17.0%]; risk difference +2.6% [95% CI -6.4 to 11.6%]). In safety analysis, the occurrence of major bleeding did not differ between the two groups. However, minor bleeding was more common in the dalteparin group (28/143 [19.6%]) than in the no dalteparin group (13/141 [9.2%]; risk difference 10.4%, 95% CI 2.3-18.4; p=0.01). INTERPRETATION: Antepartum prophylactic dalteparin does not reduce the occurrence of venous thromboembolism, pregnancy loss, or placenta-mediated pregnancy complications in pregnant women with thrombophilia at high risk of these complications and is associated with an increased risk of minor bleeding. FUNDING: Canadian Institutes of Health Research, Heart and Stroke Foundation of Canada, and Pharmacia and UpJohn.
ISSN: 0923-7577

hal-01258557
http://hal.univ-brest.fr/hal-01258557
DOI : 10.1016/S0140-6736(14)60793-5
PUBMED : 25066248

Éditeur(s) : Elsevier
Résumé : During the present study, we aimed at providing a first look at the elemental composition of the early stages of cephalopods as an approach to their elemental requirements in culture. Essential and non-essential elemental profiles of the European cuttlefish Sepia officinalis, the European squid Loligo vulgaris and the common octopus Octopus vulgaris laboratory hatchlings and wild juveniles were analysed. In addition, for O. vulgaris we determined elemental profiles of mature ovary, eggs in different stages of development and followed possible effects of four dietary treatments during paralarval rearing, also analyzing elemental content of the live preys Artemia nauplii and Maja brachydactyla hatchling zoeae. Content was determined for essential (As, Ca, Cr, Co, Cu, Fe, K, Mg, Mn, Na, Ni, P, Rb, S, Sr, Zn) and non-essemial (Ag, Al, Ba, Cd, Hg, Pb) elements. The content in non-essential elements found in hatchlings and juveniles of the three species analyzed here seems to be far lower in comparison with subadult and adult stages of coastal cephalopods. In the octopus eggs, the non-essential element concentrations remained globally low compared to hatchlings and juveniles indicating the absorption of these elements along the ontogenefic development. The elemental composition of the octopus ovary and of the eggs, hatchlings and juveniles of the three cephalopod species analyzed here showed a high content in S. As expected, the calcified internal shell of the cuttlefish, rich in Ca and Sr, originates the main difference between species. It is remarkable the richness in Cu of hatchling octopus, that may indicate a particular nutritional requirement for this element during the planktonic life. The reared octopus paralarvae feed on Artemia nauplii, a prey with relatively low Cu content, showed nearly half Cu content that the "natural" profile of octopus hatchlings or wild juveniles. This suggests a dietary effect and/or an indication of the poor physiological stage of the Artemia-fed paralarvae. At the present, the percentage of essential element absorption by food or seawater is unknown for cephalopods and should be determined in the future to understand their feeding requirements in culture. (c) 2006 Elsevier B.V. All rights reserved.
Aquaculture (0044-8486) (Elsevier), 2006-11 , Vol. 261 , N. 1 , P. 225-240

Droits : 2006 Elsevier B.V. All rights reserved
http://archimer.ifremer.fr/doc/2006/publication-2183.pdf
DOI:10.1016/j.aquaculture.2006.07.006
http://archimer.ifremer.fr/doc/00000/2183/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
52nd Congress of the European-Societies-of-Toxicology (EUROTOX)
ISSN: 0378-4274

hal-01560155
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01560155
DOI : 10.1016/j.toxlet.2016.06.2119

Éditeur(s) : HAL CCSD
Résumé : International audience
Cumulative human impacts have led to the degradation of marine ecosystems and thedecline of biodiversity in the European and contiguous seas. Effective conservationmeasures are urgently needed to reverse these trends. Conservation must entail societalchoices, underpinned by human values and worldviews that differ between the countriesbordering these seas. Social, economic and political heterogeneity adds to the challenge ofbalancing conservation with sustainable use of the seas. Comprehensive macro-regionalcoordination is needed to ensure effective conservation of marine ecosystems andbiodiversity of this region. Under the European Union Horizon 2020 framework programme,the MarCons COST action aims to promote collaborative research to support marinemanagement, conservation planning and policy development. This will be achieved bydeveloping novel methods and tools to close knowledge gaps and advance marineconservation science. This action will provide support for the development of macro-regional and national policies through six key actions: to develop tools to analysecumulative human impacts; to identify critical scientific and technical gaps in conservationefforts; to improve the resilience of the marine environment to global change and biologicalinvasions; to develop frameworks for integrated conservation planning across terrestrial,freshwater, and marine environments; to coordinate marine conservation policy acrossnational boundaries; and to identify effective governance approaches for marine protectedarea management. Achieving the objectives of these actions will facilitate the integration ofmarine conservation policy into macro-regional maritime spatial planning agendas for theEuropean and contiguous seas, thereby offsetting the loss of biodiversity and ecosystemservices in this region.
Research Ideas and Outcomes

hal-01474085
https://hal-univ-perp.archives-ouvertes.fr/hal-01474085
https://hal-univ-perp.archives-ouvertes.fr/hal-01474085/document
https://hal-univ-perp.archives-ouvertes.fr/hal-01474085/file/RIO_article_11884.pdf
DOI : 10.3897/rio.3.e11884

Éditeur(s) : The Oceanography Society
Résumé : Submarine hydrocarbon seeps are geologically driven "hotspots" of increased biological activity on the seabed. As part of the HERMES project, several sites of natural hydrocarbon seepage in the European seas were investigated in detail, including mud volcanoes and pockmarks, in study areas extending from the Nordic margin, to the Gulf of Cadiz, to the Mediterranean and Black seas. High-resolution seabed maps and the main properties of key seep sites are presented here. Individual seeps show ecosystem zonation related to the strength of the methane flux and distinct biogeochemical processes in surface sediments. A feature common to many seeps is the formation of authigenic carbonate constructions. These constructions exhibit various morphologies ranging from large pavements and fragmented slabs to chimneys and mushroom-shaped mounds, and they form hard substrates colonized by fixed fauna. Gas hydrate dissociation could contribute to sustain seep chemosynthetic communities over several thousand years following large gas-release events.
Oceanography (1042-8275) (The Oceanography Society), 2009-03 , Vol. 22 , N. 1 , P. 92-109

Droits : 2009 by The Oceanography Society. All rights reserved. Permission is granted to copy this article for use in teaching and research. Republication, systemmatic reproduction, or collective redistirbution of any portion of this article by photocopy machine, reposting, or other means is permitted only with the approval of The Oceanography Society. Send all correspondence to: info@tos.org or The Oceanography Society, PO Box 1931, Rockville, MD 20849-1931, USA.
http://archimer.ifremer.fr/doc/2009/publication-6387.pdf
DOI:10.5670/oceanog.2009.11
http://archimer.ifremer.fr/doc/00000/6387/

Éditeur(s) : EDP Sciences
Résumé : The WFD monitoring requirements for surface waters were adapted to the coastal area with the selection of the relevant parameters to qualify the maritime ecosystems, with appropriate strategies of sampling. Ifremer and Cemagref for the fish indicator in the estuarine waters, are in charge of the elaboration of the monitoring programme in coastal waters (surveillance monitoring and operational monitoring). Ifremer has elaborated technical recommendations for the monitoring of the biological (benthic and phytoplanctonic) and chemical elements, according to many years of observations by the french monitoring networks (RNO, Rephy, Rinbio, RSL, Rebent). These recommendations were established within experts groups They clarify the parameters, the analytical methods, and the strategies of sampling for the classification of the water bodies in five ecological classes and two chemical classes. The work on the relevant indicators of the ecological status still goes on, in relation with the 2006 european intercalibration exercise. Available data and future data will be used in order to set the borders between the classes of high, good, and moderate status, before the monitoring programme starts. Data sets have to be completed to set the borders and to assess the ecological status of water bodies.
Houille Blanche - Revue internationale de l'eau (0018-6368) (EDP Sciences), 2006-07 , N. 4 , P. 68-74

Droits : © Société Hydrotechnique de France 2006
http://archimer.ifremer.fr/doc/2006/publication-3530.pdf
DOI:10.1051/lhb:200604011
http://archimer.ifremer.fr/doc/00000/3530/

Éditeur(s) : Springer
Résumé : The great fecundity and very high larval mortality of most marine invertebrates and fish make possible substantial variance in the number of offspring contributed by adults to subsequent generations. The reproductive success of such organisms may thus resemble a sweepstakes lottery, in which a minority of progenitors succeeds in replacing an entire population, while the majority fails to procreate. One specific prediction of this hypothesis, that genetic diversity of newly settled cohorts should be less than that of the adult population, is tested in the present study. Microsatellite DNA markers were examined in naturally spawned juvenile European flat oysters Ostrea edulis (L.), collected over a 12-day period in 1993 from the western Mediterranean Sea, near Sete, France (43 degrees 32'N, 3 degrees 56'E) and grown out for a period of up to 10 months. Variation in these juveniles was compared to that in a pooled sample of adults collected in 1994 from two locations (Thau Lagoon and Port St. Louis) that had statistically homogeneous allelic frequencies. Though nearly twice as large as the pooled adult sample, the juvenile sample had only 60% of the adult allelic diversity. Analyses of linkage disequilibrium and kinship, as well as estimation of the effective number of parents, suggested that 10-20 adults produced this juvenile cohort. This observation supports the hypothesis of sweepstakes reproductive success and suggests that partial inbreeding may occur even in species with large populations and dispersing planktonic larvae.
Marine Biology (0025-3162) (Springer), 2007-03 , Vol. 150 , N. 6 , P. 1173-1182

Droits : 2007 Springer
http://archimer.ifremer.fr/doc/2007/publication-2616.pdf
DOI:10.1007/s00227-006-0441-y
http://archimer.ifremer.fr/doc/00000/2616/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
There are emerging concerns about potential effects on child health and development of early-life exposure to substances such as brominated flame retardants (BFRs), perfluorinated compounds (PFCs), phthalates and phenols (including bisphenol A (BPA)); pregnancy and birth cohort studies are ideally designed to study such concerns prospectively. As part of the ENRIECO project, we evaluated existing human biomonitoring data for these substances in European birth cohorts and develop recommendations for more harmonized methods that will enable combination and comparison of cohort data in the future. The ENRIECO inventory shows that 20 European birth cohorts have measured or are measuring BFRs (N=10), PFCs (N=11), phthalates (N=16) or phenols (N=8). Generally, samples were collected prenatally or at birth and measurements involved few subjects in each cohort (a few hundred maximum). Biological matrices, timing, and analytical methods of the measurements varied between cohorts. Few cohorts have measured at multiple time points or in children. In European cohorts, levels of BFRs were very low and at least 10-fold lower than in US; levels of PFCs and phthalates have decreased over the last decade since the phasing out of certain of these compounds; concentrations of phenols are comparable to those in the US. Although there is little published data in the cohorts now, many measurements are ongoing and we recommend that cohorts start working towards combined and comparison studies. Specific recommendations for use of existing data include the development of conversion models for the different media used for measurement of persistent chemicals, and inter-laboratory comparisons and calibrations. Recommendations for further data collection include more evaluation of exposure to these chemicals in children; repeated measurements of non-persistent chemicals; validation and harmonisation of questionnaires; and the development of mechanisms for fast European birth cohort response for the detection and prioritisation of new chemicals of concern.
ISSN: 1438-4639

hal-01118579
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118579
DOI : 10.1016/j.ijheh.2012.05.009
PUBMED : 22795704

Éditeur(s) : Actes de colloques Ifremer, Tahiti, French Polynesia, 20 Feb - 4 Mar 1989, n°9, chap. 15, pp.143-160
Résumé : The finfish species reared in marine intensive conditions in the French Caribbean Islands are imported (European seabass, American red drum and Oreochromis hybrids) or local (Carangids and Lutjanids) species. The European seabass (Dicentrarchus labrax ) is susceptible, during its first year of life, to a contagious disease characterized by whirling and hyperexcitability, associated with severe lesions of the brain, viral particles being pointed out in the damaged nervous cells.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/1989/acte-1478.pdf
http://archimer.ifremer.fr/doc/00000/1478/

Éditeur(s) : ICES 2008 Annual Science Conference, 22-26 september 2008, HALIFAX, CANADA
Résumé : While the majority of small-scale coastal fisheries are found in developing nations, a considerable number exist in developed nations as well. Indeed, small-scale fisheries are strongly represented in all European Union (EU) Member States, 81% and 87% of the EU 25 whole fleet is composed of vessels less than 12 and 15 meters long respectively. In 2000, European regulation established a fisheries data collection framework including economic information requirements in order to provide the scientific basis for the implementation of the Common Fisheries Policy. This paper presents the methodology designed to collect the relevant economic data and characterize the status of the French fleets from an economic perspective. Based on stratified sampling plan including the following of small-scale fleets, data collection by field survey is based on a single questionnaire for all the fleets, whatever the size of the vessel, the gear used, the fishing area or the species targeted. It provides a large data set including earnings and costs but also capital, employment, fishing activity figures. Statistical analysis through a revenue model gives the basis for a re-assessing of the small-scale fisheries contribution to national production. Economic indicators such as gross added value, revenues, and direct employment are derived from the data set. The significant role of small scale fisheries in the French fishing sector is established and the impact of the rising fuel costs in fisheries is discussed.

Droits : 2008 ICES
http://archimer.ifremer.fr/doc/00059/16998/14500.pdf
http://archimer.ifremer.fr/doc/00059/16998/

Résumé : This paper aims to establish a comprehensive Iist of exotic species introduced into Atlantic French waters over the last century as well as their origin, and the vectors involved in the process. At least 104 non indigenous species have been recorded in the Atlantic and Channel coastal wa• ters. Among those species, only a few (Bonamia ostreae, Crepidula fornicata) have resulted in highly significant negative impacts and side-effects on the coastal activity. In contrast, the introduction of the Japanese oyster Crassostrea gigas can be considered to be successful, sustaining a large industry counting more than 4,000 companies and 150,000 tons of yearly production. Over the last decade, French and European laws have strenghtened the controls over exotic species introductions, limiting their impacts. These new regulations and increased awareness from the scientific community with regard to coastal industry and biodiversity have reduced significantly the cases of deliberate introduction, while the risk analysis requirement has improved the overall management. However, in spite of these improvements, cases remain significant, mostly by accidental and/or increased vectors of introduction such as the ballast waters and sediment. Moreover, global changes should now be considered as a major issue, Iikely inducing future geographic distribution changes over a large European coastal range. Understanding the invasion population dynamics for exotic species remains a challenging research issue currently addressed by the French INVABIO multidisciplinary program.
Invasive aquatic species of Europe. Distribution, impacts and management. E. Leppäkoski, S. Gollasch & S. Olernin (eds).

Droits : 2002 Kluwer Academie Publishers. Printed in the Netherlands.
https://w3.ifremer.fr/archimer/doc/00000/3100/

Éditeur(s) : HAL CCSD
Résumé : Background. Chlorine is the most widely used disinfectant for drinking water treatment. During treatment process, the natural organic matter present in water reacts with chlorine to form disinfection by-products (DBPs), such as trihalomethanes (THMs) and haloacetic acids (HAAs), the most occurring ones. Several identified DBPs were recognized carcinogens or fetotoxic in animals. We conducted two epidemiological studies to assess the health effects of human exposure to DBPs regarding cancer and reproduction. Association between THM exposure and the risk of bladder cancer: a pooled analysis of 3 European case-control studies. The study included 2381 cases and 3086 controls from 3 case-control studies (France, Finland, Spain). Environmental exposure to SPCs was measured by THM concentrations in water distribution systems, retrospectively estimated through the 40-year exposure window. Information about water uses (tap water ingestion, showers and baths, swimming-pool attendance) was available. An increased risk of bladder cancer was observed, in men only, with increasing THM concentrations in water systems and duration of exposure to chlorinated surface water. No association was observed with exposure through tap water ingestion. Exposure through showers, baths and swimming in pools (available in Spanish study only) was associated with an increased risk of bladder cancer. Three North-American case-control studies were joined to the three European ones into a meta-regression. No specific dose-response relationship was identified for European studies. A global dose-response relationship was consequently estimated, including 4351 cases and 7055 controls. Association between DBP exposure and the risk of preterm birth and Intra-Uterine Growth Retardation (IUGR). This study was conducted within the PELAGIE cohort (3400 pregnant women included in early pregnancy, in Brittany, France, between 2002 and 2006). Exposure during pregnancy was measured by 2 indicators: THM concentrations in water distribution systems and a biomarker of HAA ingestion, the level of trichloroacetic acid in maternal urine at inclusion (in a nested case-control study). The regulatory database SISE-Eaux was used to estimate THMs concentrations in the water distribution systems. Water uses during pregnancy (ingested tap water, swimming-pool attendance, showers and bath frequencies and duration) were collected with questionnaires. Our results suggest an association between prenatal exposure to DBPs (THMs and HAAs) and the risk of IUGR. No association was found with the risk of preterm birth.
Contexte. La chloration est le traitement le plus utilisé pour désinfecter l’eau distribuée à la population. Lors du traitement, des sous-produits de chloration (SPCs) se forment par réaction de la matière organique naturelle présente dans l’eau avec le chlore. Les produits les plus présents sont les trihalométhanes (THMs), les acides haloacétiques (HAAs). Des études toxicologiques (animales et in vitro) ont montré la génotoxicité et/ou carcinogénicité et la reprotoxicité de certains SPCs. Nous avons mené deux études évaluant les effets sur la santé humaine de l’exposition aux SPCs, dans le domaine du cancer et de la reproduction. Association entre exposition aux THMs et risque de cancer de la vessie : une analyse poolée de 3 études cas-témoins européennes. Cette analyse a inclus 2381 cas et 3086 témoins issus de 3 études cas-témoins (France, Espagne, Finlande). L’exposition environnementale aux SPCs a été mesurée par la concentration en THMs estimée rétrospectivement dans les réseaux de distribution d’eau au cours des 40 années de la fenêtre d’exposition. Les usages de l’eau connus sont l’ingestion, les douches et les bains, la fréquentation de piscine (étude espagnole seulement). Une relation croissante a été observée entre le niveau environnemental de THMs, la durée d’exposition à une eau de surface chlorée et le risque de cancer de la vessie, chez les hommes uniquement. Aucune association n’a été observée avec l’exposition via l’ingestion d’eau du robinet. L’exposition via les douches, les bains et la piscine est apparue liée au risque de cancer de la vessie. Trois études cas-témoins nord-américaines ont été intégrées dans une méta-régression. Aucune spécificité européenne de la relation dose-réponse n’a été mise en évidence. Une relation dose-réponse globale incluant 4351 cas et 7055 témoins a été estimée. Association entre exposition aux SPCs et risque de prématurité et de retard de croissance intra-utérin (RCIU). Cette étude est issue de la cohorte bretonne Pélagie (3400 femmes enceintes recrutées en début de grossesse entre 2002 et 2006). L’exposition pendant la grossesse a été mesurée à l’aide de 2 indicateurs : la concentration en THMs de l’eau distribuée dans les réseaux et le dosage d’un biomarqueur urinaire (acide trichloroacétique) pour un sous-échantillon de femmes (étude cas-témoins nichée). Les niveaux dans les réseaux proviennent de la base de données réglementaire SISE-Eaux. Les usages de l’eau du robinet par les femmes pendant la grossesse ont été collectés par questionnaire (quantité d’eau du robinet bue, fréquentation de la piscine, fréquence et durée des douches et des bains). Notre étude suggère une association entre l’exposition prénatale aux SPCs et le risque de RCIU. Aucune association n’est observée avec le risque de prématurité.
https://tel.archives-ouvertes.fr/tel-00927735

Droits : info:eu-repo/semantics/OpenAccess
NNT : 2013REN1B008
tel-00927735
https://tel.archives-ouvertes.fr/tel-00927735
https://tel.archives-ouvertes.fr/tel-00927735/document
https://tel.archives-ouvertes.fr/tel-00927735/file/COSTET_DEIBER_Nathalie4.pdf

Éditeur(s) : HAL CCSD Masson
Résumé : National audience
Started in 2015 in Brazil, an outbreak linked to a little known arbovirus, Zika virus spread throughout Latin America. This virus, considered until recently as responsible of only mild symptoms, made mention of previously unsuspected complications, with severe neurological manifestations in adults and malformations of the central nervous system, including microcephaly, in newborns of mother infected during the pregnancy. While the continent is more accustomed to the succession of arbovirus epidemics, suspected complications and the many unknowns keys of the latter arriving raise many public health issues. French Guiana, a French territory located in the north-east of the continent, combines both European level of resources and climate and issues specific to the Amazon region and Latin America. We discuss here the issues for 2016 Zika virus epidemic in our region, many of them are generalizable to neighboring countries.
ISSN: 0037-9085

inserm-01422054
http://www.hal.inserm.fr/inserm-01422054
http://www.hal.inserm.fr/inserm-01422054/document
http://www.hal.inserm.fr/inserm-01422054/file/2016%2C%20Epelboin%20-%20%C3%89pid%C3%A9mie%20de%20virus%20Zika%20en%20Am%C3%A9rique%20latine%20-%20quels%20enjeux%20pour%20la%20Guyane%20%281%29.pdf
DOI : 10.1007/s13149-016-0490-5

Éditeur(s) : Edp Sciences S A
Résumé : A study on nitrogenous and phosphorous waste production in European seabass (Dicentrarchus labrax) was carried out in a flow-through land-based farm. The main objectives were (i) to calculate nitrogenous (N) and phosphorous (P) waste production (particulate and dissolved) from in situ measurements for different rearing ponds with specific fish biomasses, fish sizes and flow rates, (ii) to establish nitrogenous and phosphorous waste production budgets, ratios and equations, and (iii) to compare, for the whole farm, in situ measurements to estimate N and P waste production from waste equations. Waste production was manifest by an increase in concentrations of total ammonia nitrogen, total Kjeldhal nitrogen, particulate nitrogen, dissolved phosphorus and total phosphorus concentrations in the outlet water compared to the inlet water for both batches and whole farm. However, no production of nitrite or nitrate was observed. In our budgets, the N and P amounts from biomass gains and wastes were explained by the N and P derived from feed over the range 83.9-105.2 % and 66.5-104.6 % respectively, depending on the fish batch. Values were respectively 103.4 and 87.5 % for the same calculations in the farm. When the whole-farm waste production was calculated from previous equations derived from batches, and then compared with the measured data, the percentages of recovery (estimated by the ratio predicted data/measured data) were 88 and 94 % for total-N and total-P respectively.
L'étude de la production des déchets (azote et phosphore) d'une ferme de production de bars (Dicentrarchus labrax) est réalisée. Cette étude à pour objectif (i) de mesurer in situ la production des déchets azotés et phosphores sous forme particulaire et soluble, pour différents bassins d'élevage présentant des caractéristiques variables en terme de biomasse de poisson, de taille des poissons, de débit de l'eau de renouvellement, (ii) d'établir des équations de production de déchets à partir des données précédemment acquises, (iii) de comparer, pour l'ensemble des rejets au niveau de la ferme, les résultats obtenus par des mesures in situ, d'une part, et à l'aide des équations, d'autre part. La production de déchets se traduit par une augmentation des concentrations de l'azote particulaire, de l'azote ammoniacal, de l'azote organique dissous, ainsi que du phosphore particulaire et dissous. Aucune augmentation des nitrates et nitrites n'est observée. L'établissement des budgets d'azote et de phosphore permettent de rendre compte, selon les bassins, du devenir de 88,2 à 105,2 % de l'azote et de 66,2 à 104,6 % du phosphore introduits dans les bassins sous forme de nourriture en granulés. L'étude des budgets réalisée par les deux méthodes (mesures in situ et utilisation des équations) montre que les budgets établis à l'aide des équations rendent compte respectivement de 88 et 94 % de récupération de l'azote et du phosphore. Ces résultats sont respectivement de 103,4 et 87,5 % lorsqu'ils sont établis par des mesures in situ.
Aquatic Living Resources (0990-7440) (Edp Sciences S A), 1998-07 , Vol. 11 , N. 4 , P. 247-254

Droits : 1998 Published by Elsevier SAS
http://archimer.ifremer.fr/doc/1998/publication-872.pdf
DOI:10.1016/S0990-7440(98)89007-4
http://archimer.ifremer.fr/doc/00000/872/

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
Background: Adolescent obesity is prevalent in Pacific region ethnic groups (European, Melanesian and Polynesian) living in both urban and rural areas. Although body perception is an important factor of weight gain or loss, little is known about the body self-perceptions of Pacific region adolescents. This study therefore evaluated adolescent perceptions of body weight according to ethnicity (European, Melanesian or Polynesian), socioeconomic status (low, intermediate or high) and living area (rural or urban) in New Caledonia.Methods: Sociodemographic and anthropomorphic data from 737 adolescents (351 boys and 386 girls) with ages ranging from 11 to 16 years were collected and analysed. The International Obesity Task Force (IOTF) standards were used to define weight status as normal-weight, underweight or overweight/obese. Weight perception was assessed from detailed questionnaires, with adolescents rating their own weight with the following descriptors: 'about the right weight', 'too heavy', or 'too light'.Results: Results showed that only 8.5% of normal-weight adolescents (7% boys and 10% girls) identifying themselves as ‘too heavy’. Normal-weight Melanesian adolescents were less likely than their European counterparts to assess themselves as too heavy (OR = 0.357). However, half the overweight/obese adolescents underestimated their weight status (53% boys and 48% girls). Weight misperception was associated with ethnicity, socioeconomic status and living area, with gender-specific differences.Conclusions: The results of this study suggest that these sociodemographic factors should be taken into account when designing public health policies and health education school programmes in New Caledonia and, more broadly, the Pacific regio
ISSN: 1471-2458

Droits : info:eu-repo/semantics/OpenAccess
hal-01678909
https://hal.univ-antilles.fr/hal-01678909
https://hal.univ-antilles.fr/hal-01678909/document
https://hal.univ-antilles.fr/hal-01678909/file/Misperception%20of%20weight%20status%20in%20the%20pacific-%20preliminary%20findings%20in%20rural%20and%20urban%2011-%20to%2016-year-olds%20of%20New%20Caledonia%20Ste%CC%81phane%20Frayon%20et%20al%202017.pdf
DOI : 10.1186/s12889-016-3982-0

Éditeur(s) : HAL CCSD European Centre for Disease Prevention and Control
Résumé : International audience
Leishmaniasis is endemic in southern Europe, and in other European countries cases are diagnosed in travellers who have visited affected areas both within the continent and beyond. Prompt and accurate diagnosis poses a challenge in clinical practice in Europe. Different methods exist for identification of the infecting Leishmania species. Sixteen clinical laboratories in 10 European countries, plus Israel and Turkey, conducted a study to assess their genotyping performance. DNA from 21 promastigote cultures of 13 species was analysed blindly by the routinely used typing method. Five different molecular targets were used, which were analysed with PCR-based methods. Different levels of identification were achieved, and either the Leishmania subgenus, species complex, or actual species were reported. The overall error rate of strains placed in the wrong complex or species was 8.5%. Various reasons for incorrect typing were identified. The study shows there is considerable room for improvement and standardisation of Leishmania typing. The use of well validated standard operating procedures is recommended, covering testing, interpretation, and reporting guidelines. Application of the internal transcribed spacer 1 of the rDNA array should be restricted to Old World samples, while the heat-shock protein 70 gene and the mini-exon can be applied globally.
ISSN: 1560-7917

hal-01460743
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01460743
DOI : 10.2807/1560-7917.ES.2016.21.49.30418
PUBMED : 27983510

Éditeur(s) : HAL CCSD
Résumé : Cette thèse a été publiée dans une version remaniée et adaptée sous le titre "Niveaux C1 et C2 pour le français du Cadre européen commun de référence pour les langues, éléments pour un référentiel", Riba, P., (2016), Didier éd, Paris
This thesis sets out to examine the problems of description and specification pertaining to the C levels of the Common European Reference Framework for Languages , known as the experienced–user levels (C1 - Autonomy and C2 - Mastery), for French. It forms part of the efforts to establish yardsticks suggested by the Council of Europe and undertaken in various European countries, including France, whereby the A and B levels have already been described (J.C. Beacco, S. Bouquet, R. Porquier, 2004 ; J.C. Beacco, R. Porquier, 2007 ; J.C. Beacco, S. Lepage, R. Porquier, P. Riba, 2008 ; J.C. Beacco, B. Blin, E. Houles, S. Lepage, P. Riba, pending publication). The notional and functional components, discourse genres, functions, notions, morphosyntactic categories, phonetic content and cultural competencies and learner strategies pertaing to levels C1 and C2 have been described based on three methodological approaches that are respectively intuitive, experimental and based on the creation of standards. The thesis focuses on researching the cut-off points between levels B2, C1 and C2, which are of use to designers of teaching methods and curricula, examination writers and teachers, and it proposes the establishment of a C2+ level, which is didactically compatible with the contradictory notions of “final language level˝ and lifelong learning.
Cette thèse a pour objet la problématique de la description et la spécification des niveaux C duCadre européen commun de référence pour les langues, dits niveaux de l’utilisateurexpérimenté (C1 autonome, C2 maîtrise) pour le français. Elle s’inscrit dans la dynamique deréférentialisation souhaitée par le Conseil de l’Europe et engagée dans plusieurs payseuropéens, y compris en France, où les niveaux A et B ont déjà été décrits : B2, (J.C. Beacco,S. Bouquet, R. Porquier, (2004), A1, J.C. Beacco, R. Porquier, (2007), A2, J.C. Beacco, S.Lepage, R. Porquier, P. Riba, (2008), B1, J.C. Beacco, B. Blin, E. Houles, S. Lepage, P. Riba,(2010).La description des éléments notionnels et fonctionnels des niveaux C1 et C2, genresdiscursifs, fonctions, notions, catégories morphosyntaxiques, matière phonique, matièregraphique, compétences culturelles et stratégies d’apprentissage, a été établie en suivant troisvoies méthodologiques, intuitive, expérimentale et d’étalonnage.Elle se focalise sur la recherche des points de césure entre B2, C1 et C2 utiles pour les auteursde méthodes ou de curriculums, les concepteurs d’examens et les enseignants et elle proposeune spécification d’un niveau C2+, didactiquement compatible avec les notions paradoxalesde « dernier niveau de langue » et d’apprentissage tout au long de la vie.
https://halshs.archives-ouvertes.fr/tel-01395794

Droits : info:eu-repo/semantics/OpenAccess
NNT : 2010PA030062
tel-01395794
https://halshs.archives-ouvertes.fr/tel-01395794
https://halshs.archives-ouvertes.fr/tel-01395794/document
https://halshs.archives-ouvertes.fr/tel-01395794/file/these%20Patrick%20RIBA%20finale.pdf