Éditeur(s) : St. Thomas, V.I. : University of the Virgin Islands, Eastern Caribbean Center St. Thomas, V.I. : University of the Virgin Islands, Eastern Caribbean Center ( St. Thomas, V.I.: Eastern Caribbean Center )
Résumé : Contents: The Caribbean : diversity and typology of identities / Caribbean masculinity and educational failure Health and the mid-life and older woman / The Caribbean potential for ecotourism / La vilencia domestica como obstaculo para el desarrollo

Droits : All rights reserved by the source institution.
F1609.5 .M88 1996
http://ufdc.ufl.edu/AA00020273/00001

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
In petroleum industry, the difference between pore pressure (Pp) and minimum horizontal stress Sh (termed the seal or retention capacity) is of major consideration because it is often assumed to represent how close a system is to hydraulic failure and thus the maximum hydrocarbon column height that can be maintained. While Sh and Pp are often considered to be independent parameters, several studies in the last decade have demonstrated that Sh and Pp are in fact coupled. However, the nature of this coupling relationship remains poorly understood. In this paper, we explore the influences of the spatial pore pressure distribution on Sh/Pp coupling and then on failure pressure predictions and trap integrity evaluation. With analytical models, we predict the fluid pressure sustainable within a reservoir before failure of its overpressured shale cover. We verify our analytical predictions with experiments involving analogue materials and fluids. We show that hydraulic fracturing and seal breach occur for fluid pressure greater than it would be expected from conventional retention capacity. This can be explained by the impact of the fluid overpressure field in the overburden and the pressure diffusion around the reservoir on the principal stresses. We calculate that supralithostatic pressure could locally be reached in overpressured covers. We also define the retention capacity of a cover (RC) surrounding a fluid source or reservoir as the difference between the failure pressure and the fluid overpressure prevailing in shale at the same depth. In response to a localized fluid pressure rise, we show that the retention capacity does not only depend on the pore fluid overpressure of the overburden but also on the tensile strength of the cover, its Poisson's ratio, and the depth and width of the fluid source.
ISSN: 0264-8172

hal-00590497
https://hal.archives-ouvertes.fr/hal-00590497
DOI : 10.1016/j.marpetgeo.2010.08.007

Éditeur(s) : Workshop held in Travinh (Vietnam), 5-8 March 2002
Résumé : The economie performance of shrimp rearing is govemed by three types of factors a) the environmental conditions prevailing around the farms, b) farmers' zootechnical practise and know how, c) economie management. The Gambas project aims at identifying the relative role played by these parameters in the success or failure of small-scale shrimp farming enterprises of the Mekong delta in Vietnam. It is being conducted by French and Vietnamese partners under the co-leadership of Ifremer and the Nha Trang Institute of Oceanography.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/00083/19387/16981.pdf
http://archimer.ifremer.fr/doc/00083/19387/

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
ObjectivesTo compare the efficacy, in current clinical practice, of ă first regimens containing abacavir with lamivudine (ABC/3TC) or ă tenofovir with emtricitabine (TDF/FTC) in patients with baseline viral ă load 100000 HIV-1 RNA copies/mL. ă MethodsUsing a prospective cohort, we selected all patients starting a ă first HIV regimen based either on ABC/3TC or on TDF/FTC. The propensity ă score (PS) method was used to limit the indication bias due to the ă observational nature of the data. Adjusting and weighting methods via PS ă were used to compare the effectiveness of a first regimen containing ă ABC/3TC or TDF/FTC. The primary outcome was treatment failure by month ă 12 (M12). ă ResultsOverall, 2781 patients started an antiretroviral (ARV) regimen ă with ABC/3TC or TDF/FTC each in combination with efavirenz, boosted ă atazanavir or boosted darunavir. Among the 2472 uncensored patients ă before M12, 962 (39%) had a baseline viral load 100000 copies/mL of ă whom 294 were in treatment failure at or before M12. Our analyses showed ă no difference between ABC/3TC and TDF/FTC in the risk of treatment ă failure at M12 in patients starting an ARV regimen with a high viral ă load (100000 copies/mL). ă ConclusionsUsing a large prospectively collected cohort of patients ă seeking care in France, we found no evidence that ABC/3TC based regimens ă led to more failures than TDF/FTC based ones in patients with high ă baseline viral loads.
ISSN: 1464-2662

hal-01482656
https://hal.archives-ouvertes.fr/hal-01482656
DOI : 10.1111/hiv.12306

Éditeur(s) : EDP Sciences
Résumé : Lessons for the future from two development projects in aquaculture in the French overseas territories. Numerous research and development projects have been launched since the seventies in the French overseas territories. Their aim was to foster new activities in agriculture based on local productions for local markets, notably in the French West Indies (FWI). In this paper we analyze two development projects on the rearing of giant freshwater prawn, one in the FWI and the other in French Guyana, over twenty years after their launching. The purpose of these compared studies is twofold: first to try to understand why a set of relevant technical innovations ended in failure 15 years later; second to identify recommendations in terms of methodology in order to diminish risks of mistakes or failure for future projects. To reach this goal we followed two approaches. A first analysis is based on a set of three criteria: social acceptability, legitimacy and time planning. The second analysis, justified by the subjective need for an explanatory tool, is based on the actor-network theory. The results show that beyond the levels of political support and financial investment and support the three key criteria for success are: (i) reactivity of the decision-makers, notably when markets change, (ii) quality of leadership transfer between the launching phase and the stabilized phase, and (iii) capacity of the decision-makers to take into account the concrete consequences of the various scenarios. Regarding this third criterion, our analysis suggests that the scenario of full technical success needs to be explored, notably in terms of economic sustainability. The integration of these two types of analyses into an ex-ante frame should contribute to reducing risks of failure in similar development projects.
De nombreux projets d’aquaculture ont été menés depuis les années 1970 dans les territoires et départements français d’outre-mer. L’objectif était de diversifier l’agriculture avec des productions destinées au marché local comme aux Antilles, ou à l’exportation comme en Guyane. L’étude s’intéresse au bilan de deux projets d’élevage de la crevette tropicale d’eau douce aux Antilles et en Guyane, plus de vingt ans après leur lancement. L’objectif est de comprendre comment des innovations technologiques pertinentes ont conduit à deux échecs sur le moyen terme et de tirer des recommandations de méthode afin de réduire les risques d’erreurs ultérieures. Pour cela, deux cadres d’analyse sont mobilisés : le premier s’appuie sur les concepts de temporalité, légitimité et acceptabilité ; le second, motivé par la recherche subjective de cadres explicatifs, emprunte la vision de la théorie de l’acteur-réseau. Les trois déterminants majeurs du succès ou de l’échec se révèlent être la réactivité des responsables face aux problèmes d’adaptation à l’évolution des marchés, la qualité du transfert du leadership lors du passage de la phase de lancement à la phase de croisière et enfin la capacité de prendre en compte dès le départ les conséquences des scénarios d’évolution du projet, y compris la réussite technique. Une capacité d’intégration de ces types d’analyse, dans un cadre ex ante, devrait permettre de réduire les risques d’échec dans des projets de développement similaires à venir.
Natures Sciences et Sociétés (1240-1307) (EDP Sciences), 2013-12 , Vol. 21 , N. 4 , P. 400-415

Droits : NSS-Dialogues, EDP Sciences 2014
http://archimer.ifremer.fr/doc/00187/29784/28242.pdf
DOI:10.1051/nss/2014004
http://archimer.ifremer.fr/doc/00187/29784/

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
BACKGROUND: The potential interest of antifungal treatment of non-immunocompromized patients with sepsis, extra-digestive Candida colonization and multiple organ failure is unknown. It represents three-quarters of antifungals prescribed in Intensive Care Units. It may allow early treatment of invasive fungal infection in the incubation phase but expose patients to unnecessary antifungal treatments with subsequent cost and fungal selection pressure. As early diagnostic tests for invasive candidiasis are still considered to be insufficient, the potential interest in this strategy needs to be demonstrated. METHODS: This prospective multicenter, double blind, randomized-controlled trial is conducted in 23 French Intensive Care Units. All adult patients, mechanically ventilated for more than four days with sepsis of unknown origin and with at least one extradigestive fungal colonization site and multiple organ failure are eligible for randomization. Patients with proven invasive candidiasis are not included. After a complete mycological screening, patients are allocated to receive micafungin 100 mg intravenously once a day or placebo for 14 days. We plan to enroll 260 patients. The main objective is to demonstrate that micafungin increases survival of patients without invasive candidiasis at day 28 as compared to placebo. Other outcomes include day 28 and 90 survival and organ failure evolution. Additionally, pharmacokinetics of micafungin in enrolled patients will be measured and evolution of fungal biomarkers and susceptibility profiles of infecting fungi will also be followed. DISCUSSION: This study will help to provide guidelines for treating non-immunocompromized patients with fungal colonization multiple organ failure and sepsis of unknown origin.Trial registration: Clinicaltrials.gov number NCT01773876.
ISSN: 1745-6215

inserm-00913515
http://www.hal.inserm.fr/inserm-00913515
http://www.hal.inserm.fr/inserm-00913515/document
http://www.hal.inserm.fr/inserm-00913515/file/1745-6215-14-399.pdf
PUBMED : 24261608

Éditeur(s) : HAL CCSD Wiley
Résumé : SUBSURF
International audience
Similarity of form between subaerial and submarine landscapes affected by erosion could suggest similarities in the process of erosion, such as by runoff and sedimentary flows, respectively. On the other hand, if aspects of form vary, its characteristics may be used to identify the environmental origin of erosion. Towards these goals, this contribution addresses the morphology of submarine volcanoes (seamounts) with widely differing histories of erosion. One set from the Pacific Ocean never exposed above sea level includes Cretaceous-age seamounts near Hawai'i (including Apu'upu'u Seamount), two seamounts of < 3 Ma in age near a mid-ocean ridge and the 11-4 Ma Jasper Seamount. These seamounts are all isolated from continents and hence from any erosion associated with mass wasting of unstable terrigenous deposits. In such isolated submarine environments, surfaces erode slowly from in situ weathering, mass wasting and scouring by sedimentary flows initiated by slope failure in pelagic or bedrock materials. The Pacific seamounts are compared with Valencia Seamount in the western Mediterranean, exposed subaerially for 100-400 k.y. during the Messinian Salinity Crisis before 5 Ma. Multibeam and deeply towed sidescan sonar data of Valencia Seamount reveal features typical of subaerial erosion of volcanic islands, such as canyons and relatively uneroded sectors (planezes) between them. Using a simple topographical reconstruction, the apparent erosion depth typically reaches 100 m within canyons and up to 180 m in places. Whereas the younger Pacific seamounts do not show these erosional features, the much older Cretaceous seamounts do have channels, which in one example suggests up to 200 m of incision. Both Valencia and Apu'upu'u seamounts have channel longitudinal profiles that are steep and typically linear to concave upwards. The erosion depth of Apu'upu'u Seamount is significant, despite the seamount's persistent submarine environment, because of its greater age, steeper flanks and greater contributing areas to channels compared with Valencia Seamount. These results illustrate that the channel morphology resulting from submarine erosion can become similar to that produced by subaerial erosion given sufficient time.
ISSN: 0950-091X

hal-00411425
https://hal.archives-ouvertes.fr/hal-00411425
DOI : 10.1111/j.1365-2117.2008.00355.x

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
The premature loss of ovarian function may have physical and psychological consequences. A better understanding of its mechanism is therefore needed. Because they are affecting the oocyte quality, the decline of the ovarian reserve and high maternal age are implicated in many defects leading to chromosomal defects, modifications of gene expression or alterations of the mitochondrial pattern of the oocyte. However, cellular therapies such as ovarian follicle activation or isolation of ovarian stem cells are promising treatments of ovarian failure
Le diagnostic d’insuffisance ovarienne chez une femme ayant un projet d’enfanter aura des conséquences non seulement physiques mais également psychologiques. L’optimisation des stratégies de prise en charge thérapeutique nécessite une meilleure compréhension des mécanismes de survenue de cette défaillance. Les mécanismes responsables de la constitution et du maintien de la réserve ovarienne commencent à être élucidés. Avec le déclin de la réserve ovarienne, la qualité ovocytaire diminue, accentuant la baisse de la fertilité associée à l’âge maternel. Les ovocytes et les embryons résultant de patientes âgées présentent des taux d’aneuploïdies élevés, liés à des défauts de cohésion chromosomique et d’instabilité du fuseau méiotique, diminution de la capacité de réparation de l’ADN, altération de l’expression des gènes ou à une altération du fonctionnement mitochondrial. Avec la possibilité d’activer in vitro la folliculogenèse et l’isolement de cellules souches ovariennes, plusieurs pistes de thérapie cellulaire commencent à se développer et semblent très prometteuses.
ISSN: 1297-9589

hal-01231432
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01231432
DOI : 10.1016/j.gyobfe.2015.10.008
PUBMED : 26597936

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
The brittle to ductile transition (BDT) in rocks may strongly influence their transport properties (i.e., permeability, porosity topology ...) and the maximum depth and temperature where hydrothermal fluids may circulate. To examine this transition in the context of Icelandic crust, we conducted deformation experiments on a glassy basalt (GB) and a glass-free basalt (GFB) under oceanic crust conditions. Mechanical and micro-structural observations at a constant strain rate of 10(-5) s(-1) and at confining pressure of 100-300 MPa indicate that the rocks are brittle and dilatant up to 700-800 degrees C. At higher temperatures and effective pressures the deformation mode becomes macroscopically ductile, i.e., deformation is distributed throughout the sample and no localized shear rupture plane develops. The presence of glass is a key component reducing the sample strength and lowering the pressure of the BDT. In the brittle field, strength is consistent with a Mohr-Coulomb failure criterion with an internal coefficient of friction of 0.42 for both samples. In the ductile field, strength is strain rate-and temperature-dependent and both samples were characterized by the same stress exponent in the range 3 < n < 4.2 but by very different activation energy Q(GB) = 59 +/- 15 KJ/mol and Q(GFB) = 456 +/- 4 KJ/mol. Extrapolation of these results to the Iceland oceanic crust conditions predicts a BDT at similar to 100 degrees C for a glassy basalt, whereas the BDT might occur in non-glassy basalts at deeper conditions, i.e., temperatures higher than 550 +/- 100 degrees C, in agreement with the Icelandic seismogenic zone.
ISSN: 0148-0227

hal-00760905
https://hal.archives-ouvertes.fr/hal-00760905
DOI : 10.1029/2011JB008884

Éditeur(s) : HAL CCSD
Résumé : International audience
In most rock mechanical testing devices, the texture developed during deformation is only observed after the failure, and the detailed mapping of cracks and pore structure evolution, just before or after rupture, remains speculative. Computerized X-ray tomography (CT X-ray) offers a way to observe 'in vivo' some characteristics of a tested sample in the course of its deformation. Therefore we developed an X-ray transparent tri-axial cell that was included in a medical purpose X-ray scanner with a volumetric resolution of the order of 1 mm3. This technique is described and applied to a porous calcarenite, which is regularly scanned for porosity evolution during mechanical testing. The experiment is performed at low confining pressure (2-10 MPa). During testing, an axial load is applied until failure and is then progressively decreased. In these experiments, the peak stress is preceded by phase of diffuse dilatancy. After failure localization, the axial stress is unloaded until the stress reaches isotropy. During this unloading phase, the previous diffuse dilatancy is lost due to an elastic relaxation. Then, the stress is completely relaxed. At this moment the dilatancy increases again and the residual dilatancy is larger than that reached at the peak stress. When observed "post mortem" at microscopic scale, the dilatant structures are comprised of cataclastic deformation bands and cracks in some larger crystals.
International Journal of Rock Mechanics and Mining Science

hal-00767563
https://hal.archives-ouvertes.fr/hal-00767563
DOI : 10.1016/j.ijrmms.2012.07.020

Éditeur(s) : Springer
Résumé : Based on new multibeam bathymetric data, seismic-reflection profiles and side-scan sonar images, a great number of submarine failures of various types and sizes was identified along the northern margin of the Ligurian Basin and characterized with 3 distinct end-members concerning their location on the margin, sedimentary processes and possible triggering mechanisms. They include superficial landslides mainly located in the vicinity of the main mountain-supplied rivers and on the inner walls of canyons (typically smaller that 10(8) m(3) in volume: Type 1), deep scars 100-500 m high along the base of the continental slope (Type 2), and large-scale scars and Mass Transport Deposits (MTDs) affecting the upper part of the slope (Type 3 failures). The MTDs are located in different environmental contexts of the margin, including the deep Var Sedimentary Ridge (VSR) and the upper part of the continental slope in the Gulf of Genova (Finale Slide and Portofino Slide), with volumes of missing sediment reaching up to 1.5 x 10(9) m(3). High sedimentation rates related to hyperpycnal flows, faults and earthquake activity, together with sea-level fluctuations are the main factors invoked to explain the distribution and sizes of these different failure types.
Marine Geophysical Research (0025-3235) (Springer), 2011-03 , Vol. 32 , N. 1-2 , P. 225-243

Droits : Springer Science+Business Media B.V. 2011
http://archimer.ifremer.fr/doc/00043/15387/14028.pdf
DOI:10.1007/s11001-011-9123-3
http://archimer.ifremer.fr/doc/00043/15387/

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
A retrospective cohort study was conducted on 1541 HIV-infected patients to determine variables associated with the incidence of herpes zoster. A single failure Cox model showed that herpes zoster incidence increased following the first 6 months of antiretroviral treatment adjusted hazard ratio (AHR)=5 (95%CI=2.6-9.2), P<0.001; in the >60 years age group AHR=2 (95%CI=1-4), P=0.04; in patients in the top CD8 quartile AHR=2.1 (95%CI=1.3-3.6), P<0.001; and in patients previously reported to use crack cocaine AHR=5.9, (95%CI=1.4-25), P=0.02. Herpes zoster incidence increased in patients with CD4 counts<500 per mm(3) and gradually declined since 1992-1996, with AHR=0.3 (95%CI=0.2-0.5), P<0.001 for the 1997-2002 period and AHR=0.24 (95%CI=0.14-0.4), P<0.001 for the 2002-2008 period. Contrary to what has been described elsewhere, there was no specific effect of protease inhibitors on herpes zoster incidence. The present study is the first to suggest that crack cocaine is associated with an increased incidence of herpes zoster. The neurological or immunological effects of crack are discussed.
ISSN: 1932-6203

inserm-00921158
http://www.hal.inserm.fr/inserm-00921158
http://www.hal.inserm.fr/inserm-00921158/document
http://www.hal.inserm.fr/inserm-00921158/file/2013_Nacher_-_Predictive_factorssur herpes_zoster.pdf
DOI : 10.1371/journal.pone.0080187

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The Demerara plateau, located offshore French Guiana and Suriname, is part of a passive transform continental margin particularly prone to develop slope instabilities, probably in relation to the presence of a free distal border along its steep continental slope. Slope failure occurred at different periods (Cretaceous to Neogene) and shows an overall retrogressive evolution through time. Upslope these failure headscarp, an enigmatic regional Mio-Pliocene unconformity has been discovered through the interpretation of new academic and industrial datasets. The aim of this work is to describe and understand the origin of this surface. Our analysis shows that this unconformity is made of a series of valleys that cross-cut sedimentary strata. Each one of these valleys has a short lateral extent and is closed along two perpendicular directions, which suggests that it could correspond to a highly meandering system, or to some sub-circular depressions. The infill of these features is equivalent to the regional stratigraphic strata found outside the structures, but in a subdued position. This seems to imply that the structures have originated by a local loss of sediments at their base or by sliding processes. Furthermore, these depressions intersect each other through time, while migrating progressively downslope.We discuss a series of hypotheses that try to explain the onset and evolution of these depressions forming the Mio-Pliocene unconformity (Canyons? Slope failures? Contourite moats? Hydrate pockmarks?). Having established that these structures are depressions formed by collapse, and have many similarities with structures recently described in the literature as pockmarks associated with gas hydrate dissolution, we favor this hypothesis.We propose that these hydrate pockmarks form with a mass failure that was triggered by fluid-overpressure development at the base of the hydrate stability zone.
ISSN: 0025-3227

hal-01365920
https://hal.archives-ouvertes.fr/hal-01365920
DOI : 10.1016/j.margeo.2015.04.001

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The non-classical human leukocyte antigen-G, HLA-G, plays an important role in inducing tolerance, through its immunosuppressive effects on all types of immune cells. Immune tolerance is a key issue in the liver, both in liver homeostasis and in the response to liver injury or cancer. It would therefore appear likely that HLA-G plays an important role in liver diseases. Indeed, this molecule was recently shown to be produced by mast cells in the livers of patients infected with hepatitis C virus (HCV). Furthermore, the number of HLA-G-positive mast cells was significantly associated with fibrosis progression. The generation of immune tolerance is a role common to both HLA-G, as a molecule, and the liver, as an organ. This review provides a summary of the evidence implicating HLA-G in liver diseases. In the normal liver, HLA-G transcripts can be detected, but there is no HLA-G protein. However, HLA-G protein is detectable in the liver tissues and/or plasma of patients suffering from hepatocellular carcinoma, hepatitis B or C, or visceral leishmaniasis and in liver transplant recipients. The cells responsible for producing HLA-G differ between diseases. HLA-G expression is probably induced by microenvironmental factors, such as cytokines. The expression of HLA-G receptors, such as ILT2, ILT4, and KIRD2L4, on liver cells has yet to be investigated, but these receptors have been detected on all types of immune cells, and such cells are present in liver. The tolerogenic properties of HLA-G explain its deleterious effects in cancers and its beneficial effects in transplantation. Given the key role of HLA-G in immune tolerance, new therapeutic agents targeting HLA-G could be tested for the treatment of these diseases in the future.
ISSN: 0168-8278

hal-01134468
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134468
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134468/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134468/file/Biology%20of%20the%20immunomodulatory%20molecule%20HLA-G.pdf
DOI : 10.1016/j.jhep.2015.03.007

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
We present a 2-D Contact Dynamics discrete element model for simulating initiation and motion of rock avalanches, integrating hillslope geometry, Mohr-Coulomb rock behavior, pore pressure before avalanche triggering, and avalanche trigger. Avalanche motion is modeled as a dense granular flow of dry frictional and cohesive particles. On the basis of granular physics and shear experiments, we review some of the theories for the unexpectedly long runout of rock avalanches. Different causes are evoked, according to the strength (strong or weak) of the slip surface relative to the bulk. "Mechanical fluidization'' and "acoustic fluidization'' theories state that agitation of rock particles reduces frictional strength, increasing runout. Conversely, granular mechanics suggests that, as "shear-strain'' rate increases, granular material becomes more agitated, more dissipative, and more resistant. Another theory states that dynamic fragmentation of clasts creates an isotropic pressure that drives longer runout. In contrast, granular mechanics suggests that fragmentation may induce fluidization and strengthening of the granular material, while particle size reduction (among others) induces weakening of the granular flow and enhances long runout. Runout is also enhanced for column-like rock masses collapsing from steep hillslopes. Long runout may also be linked to thermal weakening mechanisms at the slip surface (e.g., thermal pressurization, and shear melting), which may lower drastically the shear strength. The model is illustrated with a hypothetical example of a rain-triggered avalanche, mobilizing shallowly dipping layers. Several phases are identified, including slope failure, avalanche triggering resulting from slip weakening, and avalanche motion in which rocks are folded and sheared.
ISSN: 0148-0227

hal-00420883
https://hal.archives-ouvertes.fr/hal-00420883
DOI : 10.1029/2008JF001072

Éditeur(s) : Amer Geophysical Union
Résumé : After the January 12, 2010, Haiti earthquake, we deployed a mainly offshore temporary network of seismologic stations around the damaged area. The distribution of the recorded aftershocks, together with morphotectonic observations and mainshock analysis, allow us to constrain a complex fault pattern in the area. Almost all of the aftershocks have a N-S compressive mechanism, and not the expected left-lateral strike-slip mechanism. A first-order slip model of the mainshock shows a N264 degrees E north-dipping plane, with a major left-lateral component and a strong reverse component. As the aftershock distribution is sub-parallel and close to the Enriquillo fault, we assume that although the cause of the catastrophe was not a rupture along the Enriquillo fault, this fault had an important role as a mechanical boundary. The azimuth of the focal planes of the aftershocks are parallel to the north-dipping faults of the Transhaitian Belt, which suggests a triggering of failure on these discontinuities. In the western part, the aftershock distribution reflects the triggering of slip on similar faults, and/or, alternatively, of the south-dipping faults, such the Trois-Baies submarine fault. These observations are in agreement with a model of an oblique collision of an indenter of the oceanic crust of the Southern Peninsula and the sedimentary wedge of the Transhaitian Belt: the rupture occurred on a wrench fault at the rheologic boundary on top of the under-thrusting rigid oceanic block, whereas the aftershocks were the result of the relaxation on the hanging wall along pre-existing discontinuities in the frontal part of the Transhaitian Belt. Citation: Mercier de Lepinay, B., et al. (2011), The 2010 Haiti earthquake: A complex fault pattern constrained by seismologic and tectonic observations, Geophys. Res. Lett., 38, L22305, doi:10.1029/2011GL049799.
Geophysical Research Letters (0094-8276) (Amer Geophysical Union), 2011-11 , Vol. 38 , N. L22305 , P. 7 p.

Droits : 2011 by the American Geophysical Union
http://archimer.ifremer.fr/doc/00054/16557/14071.pdf
DOI:10.1029/2011GL049799
http://archimer.ifremer.fr/doc/00054/16557/

Éditeur(s) : HAL CCSD American Medical Association (AMA)
Résumé : International audience
IMPORTANCE Although frequently used in treating intensive care unit (ICU) patients with sepsis, empirical antifungal therapy, initiated for suspected fungal infection, has not been shown to improve outcome. OBJECTIVE To determine whether empirical micafungin reduces invasive fungal infection (IFI)-free survival at day 28. DESIGN, SETTING, AND PARTICIPANTS Multicenter double-blind placebo-controlled study of 260 nonneutropenic, nontransplanted, critically ill patients with ICU-acquired sepsis, multiple Candida colonization, multiple organ failure, exposed to broad-spectrum antibacterial agents, and enrolled between July 2012 and February 2015 in 19 French ICUs. INTERVENTIONS Empirical treatment with micafungin (100mg, once daily, for 14 days) (n = 131) vs placebo (n = 129). MAIN OUTCOMES AND MEASURES The primary end pointwas survival without proven IFI 28 days after randomization. Key secondary end points included new proven fungal infections, survival at day 28 and day 90, organ failure, serum (1-3)-beta-D-glucan level evolution, and incidence of ventilator-associated bacterial pneumonia. RESULTS Among 260 patients (mean age 63 years; 91 [35%] women), 251 (128, micafungin group; 123, placebo group) were included in the modified intent-to-treat analysis. Median values were 8 for Sequential Organ Failure Assessment (SOFA) score, 3 for number of Candida-colonized sites, and 99 pg/mL for level of (1-3)-beta-D-glucan. On day 28, there were 82 (68%) patients in the micafungin group vs 79 (60.2%) in the placebo group who were alive and IFI free (hazard ratio [HR], 1.35 [95% CI, 0.87-2.08]). Results were similar among patients with a (1-3)-beta-D-glucan level of greater than 80 pg/mL (n = 175; HR, 1.41 [95% CI, 0.85-2.33]). Day-28 IFI-free survival in patients with a high SOFA score (> 8) was not significantly different when compared between the micafungin vs placebo groups (HR, 1.69 [95% CI, 0.96-2.94]). Use of empirical micafungin decreased the rate of new invasive fungal infection in 4 of 128 patients (3%) in the micafungin group vs placebo (15/123 patients [12%]) (P =.008). CONCLUSIONS AND RELEVANCE Among nonneutropenic critically ill patients with ICU-acquired sepsis, Candida species colonization at multiple sites, and multiple organ failure, empirical treatment with micafungin, compared with placebo, did not increase fungal infection-free survival at day 28.
ISSN: 0098-7484

hal-01405822
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01405822
DOI : 10.1001/jama.2016.14655
PUBMED : 27706483

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : During the 2003 summer monsoon, the Hi-CLIMB seismological stations deployed across the Himalayan Range detected bursts of high-frequency seismic noise that lasted several hours to days. On the basis of the cross correlation of seismic envelopes recorded at 11 stations, we show that the largest transient event on 15 August was located nearby a village partially destroyed on that day by a devastating debris flow. This consistency in both space and time suggests that high-frequency seismic noise analysis can be used to monitor debris flow generation as well as the evacuation of the sediment. A systematic study of one year of seismic noise, focusing on the detection of similar events, provides information on the spatial and temporal occurrence of mass movements at the front of the Himalayas. With a 50% probability of occurrence of a daily event, a total of 46 debris flows are seismically detected. Most of them were generated in regions of steep slopes, large gullies, and loose soils during the 2003 summer monsoon storms. These events are compared to local meteorological data to determine rainfall thresholds for slope failures, including the cumulative rainfall needed to bring the soil moisture content to failure capacity. The inferred thresholds are consistent with previous estimates deduced from soil studies as well as sediment supply investigations in the area. These results point out the potential of using seismic noise as a dedicated tool for monitoring the spatiotemporal occurrence of landslides and debris flows on a regional scale.
ISSN: 0148-0227

hal-00464177
https://hal.archives-ouvertes.fr/hal-00464177
DOI : 10.1029/2008JF001198

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
AimEcological connectivity is currently considered to be essential to enhance biodiversity conservation efforts and benefit adjacent areas. We evaluate the spatial structure of vulnerable marine benthic invertebrate populations based on connectivity to improve the placement of marine protected areas.LocationGulf of Lions, NW Mediterranean Sea.MethodsWe used a spatially explicit metapopulation model to explore how larval dispersal affects marine benthic invertebrate dynamics at local and regional scales. Minimum recruitment success (the proportion of larvae that settle in a site and survive between spawning and first reproduction, which is required to ensure species persistence) is proposed as a measure of vulnerability. Three contrasting simulations were constructed: closed versus connected populations, habitat loss versus recruitment failure disturbances and varying patterns of oceanographic connectivity. The rescue factor (the ratio of minimum recruitment success in connected and closed populations) quantified the decrease in vulnerability because of oceanographic connectivity.ResultsIn the Gulf of Lions, connectivity reduced population vulnerability by a rescue factor of 5.3. The minimum recruitment success for regional persistence decreased from 3% to 0.2% when species' life expectancies increased from 2 to 50 years. Connectivity enabled the spread of individuals over the entire region, but there were higher densities in sink sites, where low retention rates do not allow for local persistence (western tip of the gulf). Source sites, defined as those sites bringing metapopulation resistance to recruitment failure and stresses from habitat loss, were located in the centre of the gulf.Main conclusionsConnectivity drives the spatial structure of population density distribution and population vulnerability in the absence of any other structuring factor. In the Gulf of Lions, marine protected areas are located in population sinks; however; if protection measures were taken in the central part, populations would benefit throughout the region via the rescue effect.
ISSN: 1366-9516

hal-01341743
https://hal-univ-perp.archives-ouvertes.fr/hal-01341743
DOI : 10.1111/ddi.12254

Éditeur(s) : HAL CCSD American Physical Society
Résumé : International audience
This is the second of two papers investigating the mechanical response of cemented granular materials by means of contact dynamics simulations. In this paper, a two-dimensional polydisperse sample with high void ratio is sheared in a load-controlled simple shear numerical device until the stress state of the sample reaches the yield stress. We first study the stress transmission properties of the granular material in terms of the fabric of different subsets of contacts characterized by the magnitude of their normal forces. This analysis highlights the existence of a peculiar force carrying structure in the cemented material, which is reminiscent of the bimodal stress transmission reported for cohesionless granular media. Then, the evolution of contact forces and torques is investigated trying to identify the micromechanical conditions that trigger macroscopic yielding. It is shown that global failure can be associated to the apparition of a group of particles whose contacts fulfill at least one of the local rupture conditions. In particular, these particles form a large region that percolates through the sample at the moment of failure, evidencing the relationship between macroscopic yielding and the emergence of large-scale correlations in the system.
ISSN: 1539-3755

hal-00523451
https://hal.archives-ouvertes.fr/hal-00523451
DOI : 10.1103/PhysRevE.82.011304