Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
BACKGROUND: Sampling design is a key issue when establishing species inventories and characterizing habitats within highly heterogeneous landscapes. Sampling efforts in such environments may be constrained and many field studies only rely on subjective and/or qualitative approaches to design collection strategy. The region of Cacao, in French Guiana, provides an excellent study site to understand the presence and abundance of Anopheles mosquitoes, their species dynamics and the transmission risk of malaria across various environments. We propose an objective methodology to define a stratified sampling design. Following thorough environmental characterization, a factorial analysis of mixed groups allows the data to be reduced and non-collinear principal components to be identified while balancing the influences of the different environmental factors. Such components defined new variables which could then be used in a robust k-means clustering procedure. Then, we identified five clusters that corresponded to our sampling strata and selected sampling sites in each stratum. RESULTS: We validated our method by comparing the species overlap of entomological collections from selected sites and the environmental similarities of the same sites. The Morisita index was significantly correlated (Pearson linear correlation) with environmental similarity based on i) the balanced environmental variable groups considered jointly (p = 0.001) and ii) land cover/use (p-value<0.001). The Jaccard index was significantly correlated with land cover/use-based environmental similarity (p-value = 0.001). CONCLUSIONS: The results validate our sampling approach. Land cover/use maps (based on high spatial resolution satellite images) were shown to be particularly useful when studying the presence, density and diversity of Anopheles mosquitoes at local scales and in very heterogeneous landscapes.
BMC Ecology

pasteur-00914104
https://hal-riip.archives-ouvertes.fr/pasteur-00914104
https://hal-riip.archives-ouvertes.fr/pasteur-00914104/document
DOI : 10.1186/1472-6785-13-45
PUBMED : 24289184

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : La présente étude a été menée dans les cantons de la préfecture de Doufelgou au Nord Togo. Sur la base de la beauté du paysage, des richesses naturelles et des enquêtes semi-structurées, le potentiel écotouristique de cette préfecture a été évalué. Le traitement des données spatiales collectées a permis de réaliser la carte écotouristique et de proposer un circuit touristique. Trois catégories de potentialités ont été répertoriées : les potentialités naturelles, les potentialités culturelles et les potentialités anthropiques. Ces potentialités peu valorisées subissent à des degrés variables diverses pressions susceptibles de les mettre en péril. Cet article présente ces diverses potentialités et analyse les opportunités socio-économique et environnementale d’un développement écotouristique dans cette zone.
This study was conducted in the cantons of Doufelgou prefecture in Northern Togo. On the basis of the beauty of the landscape, natural resources and semi-structured surveys, the potential ecotourism in this prefecture was evaluated. The treatment of spatial data collected helped make ecotourism map and to propose a tourist circuit. Three categories of potential have been identified: the natural potential, cultural potential and human potential. These potentialities are little valued and suffer to varying degrees various pressures which may put them at risk. This paper presents various potential and carries an analysis on socio-economic and environmental benefits of ecotourism development in this area.
Doufelgou
Togo

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.6326
http://journals.openedition.org/etudescaribeennes/6326

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Purpose The objective of this article was to estimate the social cost of respiratory cancer cases attributable to occupational risk factors in France in 2010. Methods According to the attributable fraction method and based on available epidemiological data from the lit- erature, we estimated the number of respiratory cancer cases due to each identified risk factor. We used the cost- of-illness method with a prevalence-based approach. We took into account the direct and indirect costs. We estimated the cost of production losses due to morbidity (absenteeism and presenteeism) and mortality costs (years of production losses) in the market and nonmarket spheres. Results The social cost of lung, larynx, sinonasal and mesothelioma cancer caused by exposure to asbestos, chromium, diesel engine exhaust, paint, crystalline silica, wood and leather dust in France in 2010 were estimated at between 917 and 2,181 million euros. Between 795 and 2,011 million euros (87-92 %) of total costs were due to lung cancer alone. Asbestos was by far the risk factor representing the greatest cost to French society in 2010 at between 531 and 1,538 million euros (58-71 %), ahead of diesel engine exhaust, representing an estimated social cost of between 233 and 336 million euros, and crystalline silica (119-229 million euros). Indirect costs represented about 66 % of total costs. Conclusion Our assessment shows the magnitude of the economic impact of occupational respiratory cancers. It allows comparisons between countries and provides valu- able information for policy-makers responsible for defining public health priorities.
ISSN: 1618-7598

halshs-00922838
https://halshs.archives-ouvertes.fr/halshs-00922838
DOI : 10.1007/s10198-013-0528-6
PUBMED : 23974964

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
Exposure to disturbance is rarely considered in marine protected area planning. Typically, representing and replicating the habitat types present within protected areas is used to spread the risk of protecting frequently disturbed sites. This was the approach used during the 2004 re-zoning of the Great Barrier Reef Marine Park (GBRMP) via the Representative Areas Program. Over 10 years later, we examine whether the risk was spread by mapping exposure of coral reefs in the GBRMP to four disturbances that cause coral mortality: bleaching, tropical cyclones, crown-of-thorns starfish outbreaks, and freshwater inundation. Our objectives were to: (1) assess whether no-take areas include a range of disturbance regimes, and (2) identify coral reef areas with lower relative exposure. At least 13% and an average of 31% of reef locations in each of 11 exposure classes are included within no-take areas. A greater proportion of low-exposure areas are within no-take areas than high-exposure areas (34.2% vs. 28.3%). The results demonstrate the value of risk spreading when exposure data are not available while also showing that regularly assessing exposure increases capacity for adaptive, resilience-based reef management.
ISSN: 1755-263X

Droits : http://creativecommons.org/licenses/by/
hal-01225201
https://hal-univ-perp.archives-ouvertes.fr/hal-01225201
https://hal-univ-perp.archives-ouvertes.fr/hal-01225201/document
https://hal-univ-perp.archives-ouvertes.fr/hal-01225201/file/Maynard_et_al-2015-Conservation_Letters.pdf
DOI : 10.1111/conl.12198

Éditeur(s) : HAL CCSD Institut de Géographie Alpine
Résumé : International audience
The international symposium on «Urban Growth and Natural Hazards, in particular in Developing Countries» was held in the University Blaise Pascal, Clermont-Ferrand (France) on December 2 and 3, 1994. This meeting brought together about 70 research people, Ph.D. students, and professionals from France and 12 countries, representing universities, research agencies, as well as government and private companies. The symposium aimed to gather specialized people who are engaged and acting in programmes on hazard appraisal, risk prevention and urban management in city environment. These people aimed to compare experiences acquired in two different fields: on the one hand urban growth and its consequences, and on the other hand, natural hazards and effects, in particular in Developing Countries.Half-way through the International Decade for Natural Hazard Disaster Reduction, we strove to reconcile two points of view usually distincts: nature-oriented research and society-oriented research on hazards. These convergent approaches should merge, not only to improve knowledge of natural hazards and risks, but also to cope with hazard and risk situation on a day-basis in a city. We also choose to study both approaches in Developing Countries (DC) because most of the large cities of the world already are or will be located there in near future. In addition, city location in DC coincides with tropical areas where natural hazards are most frequent threats to life, in particular in mountains, on seashores, and on active convergent plate margins. We stress the fact that the 3 following topics are often lacking in studies which have been carried out on natural hazard appraisal and management. 1) How should we include social and economical factors, and particularly a sound analysis of vulnerability of people and values at risk ? 2) How should we cope with hazard management in large cities of Developing Countries ? 3) What is the specific task of research people in hazard case studies engaged in urban environment and management?Three themes correspond to the three sessions of the symposium. (1) Natural hazards and environmental factors : inventory, diagnostic and classification, (2) Vulnerability of urban society and environment : concepts, approaches, and classification, (3) Tools for urban risk prevention and risk management in case of crisis and catastrophes.
Ce numéro de la Revue de Géographie Alpine reprend une dizaine parmi les 41 contributions exposées par des chercheurs français et étrangers lors du colloque international « Croissance urbaine et risques naturels dans les pays en développement » qui s'est déroulé à l'Université Blaise Pascal, Clermont-Ferrand, les 2 et 3 décembre 1994. L'objectif général du colloque était de rassembler les diverses compétences existant en France et à l'étranger dans le domaine de l'évaluation et de la gestion des risques naturels et de confronter les expériences acquises à l'interface entre les villes en croissance et le champ d'action des phénomènes naturels créateurs de risques. Le colloque a donc réuni des chercheurs, des doctorants et des praticiens français et leurs collègues étrangers chargés de prévention, de gestion des risques naturels et de gestion urbaine, principalement dans les grandes villes des pays en développement (P.E.D.).Parvenus à mi-chemin de la Décennie Internationale pour la Prévention des Catastrophes Naturelles, nous avons porté des regards croisés sur les approches naturalistes et sociologiques des risques naturels. Il est maintenant nécessaire de faire converger ces approches, non seulement dans la connaissance des menaces et des risques, mais dans la gestion du risque quotidien en milieu urbain. Nous avons concentré ces approches dans les pays en développement ; en effet, le site de leurs grandes villes coïncide souvent avec le champ d'action des phénomènes naturels générateurs de risques, notamment dans la zone intertropicale et en particulier dans les marges continent ales actives (par exemple autour du Pacifique).Nous avons porté l'accent sur 3 points principaux, qui semblent en partie faire défaut dans les études et les méthodes actuellement mises en oeuvre dans la gestion des risques naturels : 1) comment prendre en compte les aspects socio-économiques, en particulier les types d'analyse des vulnérabilités ? 2) comment aborder la gestion des risques en milieu urbain dans les P.E.D. ? 3) quel rôle doit jouer le chercheur en Sciences de l'Homme, de la Société et de la Terre dans les analyses, les expertises consacrées aux risques et surtout dans leur gestion globale, à la charnière des sociétés citadines précaires et des milieux « naturels » contraignants ?Les contributions ont été regroupées, exposées et discutées lors du colloque sous forme de 3 thèmes. (1) Les phénomènes naturels créateurs de dommages (= menaces) : diagnostic, inventaire et typologie, (2) Les vulnérabilités des sociétés et des espaces urbanisés : concepts, typologie et modes d'analyse, (3) Les outils d'aide à la prévention et à la gestion du risque en milieu urbain.
Colloque international : "Croissance urbaine et risques naturels dans les pays en développement"
Clermont-Ferrand, Université Blaise Pascal, France

ISBN : 0035-1121
hal-01165252
https://hal.archives-ouvertes.fr/hal-01165252

Éditeur(s) : HAL CCSD
Résumé : International audience
OBJECTIVE: Contemporary pesticides, such as triazines or organophosphates, possess immunotoxic properties. We aimed to determine whether prenatal environmental exposure to these current-use pesticides was associated with otitis media (OM) during the first 2 years of life among children from the PELAGIE mother-child cohort. METHODS: The PELAGIE cohort enrolled 3421 women at the beginning of pregnancy in Brittany (France). At the 2-year follow-up, 1505 families completed a self-administered questionnaire, including the domestic use of pesticides and consumption of organic diet during pregnancy and occurrences of OM in the child. Two health outcomes were considered: at least one OM and recurrent OM (at least three). Multivariate logistic regression models that adjusted for known risk factors of OM were performed. Metabolites of triazine herbicides and organophosphate insecticides measured in urine collected before the 19th week of gestation (248 mothers) were considered in a subgroup analysis. Multiple imputation was used to handle missing values for the covariates. RESULTS: Children whose mothers reported an organic diet during pregnancy had a reduced risk of OM (at least one episode, p trend=0.01). No association was found between any outcome and residential proximity to crops. The presence in maternal urine of dealkylated triazine metabolites (OR=2.12 (1.01 to 4.47)) was positively associated with recurrent OM. CONCLUSIONS: To the best of our knowledge, this is the first work to suggest a positive association between prenatal exposure to current-use pesticides and the occurrence of parent-reported OM in young children
Occupational and Environmental Medicine

hal-01201944
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01201944
DOI : 10.1136/oemed-2015-103039
PUBMED : 26347056

Éditeur(s) : HAL CCSD Lippincott, Williams & Wilkins
Résumé : International audience
BACKGROUND:Fever in infants younger than 3 months is generally a cause for concern because of the risk for a serious bacterial infection. The aim of this study was to describe clinical and biological features of Chikungunya infection in infants < 3 months of age hospitalized in Cayenne Hospital during the 2014-2015 outbreak.METHODS:We performed a preliminary retrospective study followed by a prospective study from March 2014 to February 2015. All infants younger than 3 months presenting with fever and hospitalized in Cayenne Hospital were included. The main diagnostic criteria were fever and positive Chikungunya PCR.RESULTS:One hundred and twenty infants were hospitalized with fever. The mean age was 46 days (SD± 22 days). The mean hospitalization duration was 7.4 days (SD± 6.1 days). Chikungunya infection was diagnosed in 26 children. The most important clinical findings were high (80.8% [77.5-84]) and prolonged fever (76.9%, [73.4-80.4]), irritability (96.2% [94.5-97.7]) and skin rash. (69.2%, [65.4-73]). Half of the infants presented edema of the extremities (hands and feet principally). However, in 15 %, Chikungunya infection was associated with a serious bacterial infection. Infants who presented with irritability, high fever and elevated PCT were at high risk for Chikungunya: OR 39, [9.2-243] (p < 0.001), with a specificity of 96.7 % and a negative predictive value of 89.4%. The area of the ROC curve was 0.96 CONCLUSIONS:: Our results confirm that Chikunguyna infection is a cause of high fever in infants younger than 3 months. Our data should be confirmed by larger studies.
ISSN: 0891-3668

inserm-01476019
http://www.hal.inserm.fr/inserm-01476019
http://www.hal.inserm.fr/inserm-01476019/document
http://www.hal.inserm.fr/inserm-01476019/file/2017%2C%20Elenga%20-%20Chikungunya%20Infection%20in%20hospitalized%20febrile%20infants.pdf
DOI : 10.1097/INF.0000000000001541

Résumé : The use of acoustical systems in various human activities in the ocean (industry, defence, science) raises the issue of their impact upon marine mammals populations. Several serious accidents linked to the use of naval sonars led the military, industrial and scientific communities to investigate the potential dangers of their own activity. This report aims at identifying the risks for the cetaceans linked to the use of acoustic and seismic systems currently used for oceanographic science. The analysis proposed here stays within the frame of bibliography synthesis and elementary modelling, and brings no new scientific elements on the topic. An overview of the status of cetacean populations is given first, with a summary of the possible acoustical threats. Risks are classified and described, insisting on the cases of massive stranding events. The present status of knowledge about auditory characteristics of cetaceans is summarised, and the definition of an objective threshold for acoustical risk is discussed ; the usually-admitted values are finally retained, despite of their evident limitations. The report presents also the emission characteristics of the various acoustic and seismic systems used in oceanographic, emphasising the ones operated by Ifremer; for the potentially harmful ones (according to the currently-used criteria) a model is proposed for the radiated acoustical intensity field, giving the extent of risk areas. This analysis concludes to the harmlessness of most systems, excepted heavy seismics and at a lesser degree low-frequency multibeam echosounders. Finally a variety of possible mitigation measures are presented and discussed; the regulations imposed by some countries are detailed. The report finally recommends both short-term measures aimed at limiting the potential risks, and longer-term actions for participating in the general effort of scientific and technological research in this field.
L'emploi des systèmes acoustiques dans les diverses activités humaines en milieu océanique (industrielles, de défense, scientifiques) pose le problème de leur impact sur les populations de mammifères marins. L'évidence de plusieurs événements graves liés à l'utilisation de sonars navals a amené les communautés militaires, industrielles et scientifiques à s'interroger sur les dangers potentiels de leurs propres activités. Le présent rapport tente de cerner les risques, pour les Cétacés, liés à l'emploi des systèmes acoustiques et sismiques couramment mis en oeuvre pour la recherche océanographique. L'analyse proposée ici reste à un niveau de synthèse bibliographique et de modélisation élémentaire, et n'offre pas d'éléments scientifiques nouveaux sur la question. On commence par donner un panorama de la situation des populations de cétacés et des agressions sonores qui les menacent. Les risques acoustiques sont répertoriés et décrits, en insistant sur les cas avérés d'échouages massifs. L'état actuel de connaissances sur les caractéristiques auditives des cétacés est résumé, et la définition d'un seuil objectif de risque acoustique est discutée ; on retient par défaut les valeurs de seuils généralement admises actuellement, en dépit de leurs limitations évidentes.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/2007/rapport-2390.pdf
http://archimer.ifremer.fr/doc/00000/2390/

Éditeur(s) : HAL CCSD
Résumé : International audience
The identification and economic valuation of ecosystem services (ES) are becoming important components of coral reef management. In many contexts, protection of human assets against coastal floods is one of the most important ES provided by coral reefs. The methods utilized to characterize this ES should be able to accommodate situations with low data availability, without sacrificing robustness. In this paper, we suggest such an approach that utilizes expert opinion and does not require copious amounts of data. Our primary objective is to find a balance between simple and complex models that can be used in a data scarce environment, to produce an economic valuation of the coral reef ES of protection against coastal floods. The approach has three steps: (i) identify geographic zones and assets at risk, (ii) identify the contributing role of coral reefs in the protection of coasts and, (iii) value the annual repair costs of assets through the avoided damage cost approach. The proposed method seems appropriate for advocacy with policy makers, but appears to be less effective for small scale approaches, such as those required for Payment for ES negotiations or marine spatial planning.
Ecosystem Services

hal-01359394
https://hal-univ-perp.archives-ouvertes.fr/hal-01359394
DOI : 10.1016/j.ecoser.2016.07.005

Éditeur(s) : HAL CCSD
Résumé : International audience
Early antifungal therapeutic strategies are proposed during invasive fungal infection (IFI), but antifungal stewardship programs should institute a systematic reevaluation of prescriptions, particularly in the context of empirical treatment. Here, we aimed to evaluate the performances and particularly the negative predictive value (NPV) of diagnostic strategies, including a whole blood panfungal quantitative PCR assay (PF-qPCR) in a high risk population for IFI. The first step was to standardize and optimize a new PF- rtPCR targeting ITS2 region. Then, this method was evaluated in a multicenter prospective study including 313 patients with suspected IFI for whom an early antifungal treatment was prescribed. All patients enrolled at day 0 of their treatment benefited from serum Aspergillus galactomannan (GM) antigen detection twice a week, weekly PF-qPCR assay, and when indicated and feasible, CT-scan and mycological sampling. In total, 125 of 313 patients were diagnosed with IFI: 68 invasive aspergillosis (eight proven, 48 probable and 12 possible), one fusariosis, 47 candidemia, three disseminated candidiasis and six cryptococcosis. Globally, the sensitivity of the PF-qPCR assay was only 40%, but the specificity, PPV and NPV were 96%, 88% and 69%, respectively. In the population of patients at high risk for invasive aspergillosis who also benefited from Aspergillus GM detection, the sensitivity and the NPV of the combined detection reached to 78% and 84%, respectively. Even higher NPV were obtained when combining negative PF-qPCR and CT scan (95%) as well as negative GM and CT scan (93%), thus allowing to rationalize and re-evaluate the prescription of empirical treatment in such highly selected population.
The Journal of Infection

hal-01146845
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01146845
DOI : 10.1016/j.jinf.2015.04.005
PUBMED : 25896093

Éditeur(s) : HAL CCSD
Résumé : International audience
The k-nearest neighbors (k-NN) classification rule is still an essential tool for computer vision applications, such as scene recognition. However, k-NN still features some major drawbacks, which mainly reside in the uniform voting among the nearest prototypes in the feature space. In this paper, we propose a new method that is able to learn the "relevance" of prototypes, thus classifying test data using a weighted k-NN rule. In particular, our algorithm, called Multi-class Leveraged k-nearest neighbor (MLNN), learns the prototype weights in a boosting framework, by minimizing a surrogate exponential risk over training data. We propose two main contributions for improving computational speed and accuracy. On the one hand, we implement learning in an inherently multiclass way, thus providing significant computation time reduction over one-versus-all approaches. Furthermore, the leveraging weights enable effective data selection, thus reducing the cost of k-NN search at classification time. On the other hand, we propose a kernel generalization of our approach to take into account real-valued similarities between data in the feature space, thus enabling more accurate estimation of the local class density. We tested MLNN on three datasets of natural images. Results show that MLNN significantly outperforms classic k-NN and weighted k-NN voting. Furthermore, using an adaptive Gaussian kernel provides significant performance improvement. Finally, the best results are obtained when using MLNN with an appropriate learned metric distance.
Proceedings of the 10th Asian Conference on Computer Vision, ACCV 2010, November 8-12, 2010, Queenstown, New Zealand
Queenstown, New Zealand

hal-00664606
https://hal.inria.fr/hal-00664606
https://hal.inria.fr/hal-00664606/document
https://hal.inria.fr/hal-00664606/file/mlnn_accvfinal.pdf

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
People are exposed to multiple pollutants, especially indoors, in particular through ingestion of indoor settled dust. In the perspective of a cumulative risk assessment, a multi-residue analytical method based on pressurized liquid extraction (PLE) and gas chromatography/tandem mass spectrometry (GC/MS/MS) was developed for the simultaneous analysis in indoor dust of several classes of semi-volatile organic compounds (SVOCs) of health concern, from trace to highly concentrated compounds, including musk fragrances, organochlorines (OCs), organophosphates (OPs), polycyclic aromatic hydrocarbons (PAHs), polybromodiphenylethers (PBDEs), polychlorobiphenyls (PCBs), phthalates and pyrethroids. The method was validated in terms of limits of quantification (LOQ), and accuracy and precision via spiking experiments on an inert material (Celite(®) 545) and replicate analysis of the standard reference material SRM 2585 supplied by the National Institute of Standards and Technology (NIST). Method LOQs for 200 mg samples of sieved dust were 26 ng g(-1) for PCBs and some OCs, 65 ng g(-1) for musks, OPs, PAHs, PBDEs, pyrethroids, other OCs and some phthalates, 132 ng g(-1) for butylbenzylphthalate (BBP), 197 ng g(-1) for tributylphosphate and 1579 ng g(-1) for other phthalates. Quadratic calibration curves were established for each compound by analyzing at least five calibration solutions and exhibited determination coefficients higher than 0.999. The method was successfully applied to the SRM 2585 and seven real indoor dust samples. The results obtained on SRM 2585 demonstrate both excellent reproducibility and agreement with the indicative, reference or certified values and provide, for the first time, indicative concentrations for chlorpyrifos, diazinon, diisononylphthalate (DiNP) and tetramethrin. The results obtained on real dust samples illustrate the ability of the proposed method to quantify a wide range of SVOCs in a single analysis, making it appropriate for environmental monitoring programs or large-scale studies with a large number of samples.
ISSN: 0021-9673

hal-00994493
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00994493
DOI : 10.1016/j.chroma.2014.02.004
PUBMED : 24598454

Éditeur(s) : HAL CCSD American Society of Clinical Oncology
Résumé : International audience
PURPOSE: Determining whether environmental estrogens are associated with the risk of prostate cancer may have important implications for our general understanding of this disease. The estrogenic insecticide chlordecone was used extensively in the French West Indies, contaminating the population for more than 30 years. We analyzed the relationship between exposure to chlordecone and the risk of prostate cancer. PATIENTS AND METHODS: We investigated 623 men with prostate cancer and 671 controls. Exposure was analyzed according to case-control status, using either current plasma concentration or a cumulative exposure index based on years of exposure. We genotyped two single-nucleotide polymorphisms (rs3829125 and rs17134592) in the gene encoding chlordecone reductase. RESULTS: We found a significant increase in the risk of prostate cancer with increasing plasma chlordecone concentration (odds ratio [OR], 1.77; 95% CI, 1.21 to 2.58 for the highest tertile of values above the limit of detection [LD]; P trend = .002) and for cumulative exposure index (OR, 1.73; 95% CI, 1.04 to 2.88 for the highest quartile; P trend = .004). Stronger associations were observed among those with a positive family history of prostate cancer and among those who had lived in a Western country. The rs3829125 and rs17134592 allele variants were in complete linkage disequilibrium and were found at low frequency (0.04). Among subjects with plasma chlordecone concentrations above the LD, carriers of the allele variants had a higher risk of prostate cancer (OR, 5.23; 95% CI, 0.82 to 33.32). CONCLUSION: These findings support the hypothesis that exposure to environmental estrogens increases the risk of prostate cancer.
ISSN: 0732-183X

inserm-00518099
http://www.hal.inserm.fr/inserm-00518099
DOI : 10.1200/JCO.2009.27.2153
PUBMED : 20566993

Éditeur(s) : HAL CCSD MDPI
Résumé : International audience
Hand disinfection with alcohols-based hand rubs (ABHRs) are known to be the most effective measure to prevent nosocomial infections in healthcare. ABHRs contain on average 70% by weight of one or more alcohols. During the hand rubbing procedure, users are exposed to these alcohols not only through dermal contact, but also via inhalation, due to the physical and chemical properties of alcohols volatilizing from alcoholic solutions or gels into the air. Ethanol ingestion is well known to increase risks of several diseases (affecting the pancreas, liver, cardiovascular system…), but there is a lack of knowledge about the effects of exposure to other alcohols (including n- or isopropanol) via inhalation and dermal contact, despite the worldwide use of ABHRs. This work aims at discussing possible health effects related to unintentional alcoholization (via inhalation and dermal contact) from professional ABHR usage to suggest the need for more research in this area (but not to question the value of ABHRs). Based upon an average of 30 hand rubbings per healthcare professional per day, it can be assumed that a healthcare worker may be exposed to a maximum 5,500 mg/m(3) per work shift, five times above the recommended occupational time weighted average limit. Thus, in order to answer the question posed in the title, studies on spatial and temporal variability of alcohol emission from ABHRs in real world situations and studies on certain high risk individuals are needed.
ISSN: 1660-4601

hal-01122305
https://hal.archives-ouvertes.fr/hal-01122305
PUBMED : 20948945
DOI : 10.3390/ijerph7083038
PUBMEDCENTRAL : PMC2954566

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
We show how to introduce the Value at Risk (VaR) concept in the analysis of the adaptation of the shape of a soft bed to a flow knowing the Probability Density Function (PDF) of the responses of the shape to flow perturbations (bed receptivity). Our aim is to quantify our confidence on simulation scenarios by an available morphodynamic model for the shape. The approach permits to perform this task at low complexity as it does not require any sampling of the bed receptivity parameter space. The paper goes beyond stationarity for the variability of the bed receptivity by linking its dynamics to the bottom morphodynamics through an original transport equation for the local bed receptivity standard deviation. The approach has been applied to the analysis of bed morphodynamics based on minimization principles. The results show the importance of including uncertainty information during the coupling and not only eventually through simple margins on the results.
ISSN: 0045-7930

hal-01054937
https://hal.archives-ouvertes.fr/hal-01054937
https://hal.archives-ouvertes.fr/hal-01054937/document
https://hal.archives-ouvertes.fr/hal-01054937/file/paper_var_litto.pdf
DOI : 10.1016/j.compfluid.2013.10.021

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
Background: Overweight in Guadeloupe is a public health matter affecting children and adults. In the present study we evaluated the metabolic profile, including serum ghrelin, leptin and adiponectin levels, in normal weight, overweight and obese school children and we analyzed the potential changes in anthropometric and metabolic risk factors after a 1-year lifestyle intervention program. Methods: Parameters were assessed at baseline and at 1 year. Three groups (G) were defined according the International Obesity Task Force reference values, G1: normal weight / G2: overweight / G3: obese. The lifestyle intervention included dietary counseling, regular physical activity and family support. Results: A total of 120 children (G1: n = 44, G2: n = 39, G3: n = 37), aged 11– 15 years and 59 % girls were enrolled. Obese children showed significant lower HDL-C, adiponectin and ghrelin concentrations, higher triglycerides, fasting blood glucose, insulin and leptin levels and also higher frequencies of abdominal obesity (G1: 2.3 %, G2: 28.2 %, G3: 73 %) and insulin resistance (GI: 39 %, G2: 72 %, G3: 89 %) than the other groups. In the overall sample, the linear regressions exploring the associations of ghrelin, adiponectin and leptin with age, gender, BMI z-score, HOMA-IR and tanner stage as independent variables showed strong associations of leptin levels with weight status and insulin resistance at baseline. The models accounted for 58 % of variability in leptin levels compared with 26 and 15 % for adiponectin and ghrelin levels respectively. In 83 children who completed the program, significant decreases in BMI z-score in overweight and obese children were noted. Leptin levels decreased significantly only in the obese group whereas adiponectin concentrations increased significantly in the three groups, In obese children, a significant correlation was found between changes in BMI Z-score, and changes in leptin levels (r = 0.39; P = 0.049) but not with changes in adiponectin levels. Conclusions: Abdominal obesity and insulin resistance were highly prevalent in obese children highlighting their risk of metabolic complications in adulthood. A 1-year long lifestyle intervention was associated with improvement in BMI z-score and metabolic parameters.
ISSN: 1743-7075

Droits : http://creativecommons.org/licenses/by/
hal-01231394
http://hal.upmc.fr/hal-01231394
http://hal.upmc.fr/hal-01231394/document
http://hal.upmc.fr/hal-01231394/file/art_10.1186_s12986-015-0039-9.pdf
DOI : 10.1186/s12986-015-0039-9

Éditeur(s) : Elsevier
Résumé : Uptake of waterborne Cd, Co, Mn and Zn was determined in laboratory experiments using radiotracer techniques (Cd-109, Co-57, Mn-54 and Zn-65). Labelled Zn was mainly accumulated in the digestive gland (65%) and Co in kidneys (81%); Cd and Mn were similarly distributed in digestive gland and gills. In a complementary field study, Ag, As, Cd, Co, Cr, Cu, Fe, Mn, Ni, and Zn were analysed in scallops collected at two stations showing different contamination levels. Digestive gland and kidneys displayed the highest concentrations. Ag, As, Cd, and Fe differed in soft tissues from the two stations, suggesting that Comptopallium radula could be a valuable local biomonitor species for these elements. Low Mn and Zn concentrations found in kidneys suggest that their content in calcium-phosphate concretions differs from the other pectinids. Preliminary risk considerations suggest that As would be the only element potentially leading to exposure of concern for seafood consumers. (c) 2007 Elsevier Ltd. All rights reserved.
Environmental Pollution (0269-7491) (Elsevier), 2008-04 , Vol. 152 , N. 3 , P. 543-552

Droits : 2007 Elsevier Ltd All rights reserved.
http://archimer.ifremer.fr/doc/2008/publication-6953.pdf
DOI:10.1016/j.envpol.2007.07.009
http://archimer.ifremer.fr/doc/00000/6953/

Éditeur(s) : HAL CCSD
Résumé : The functioning of ecosystems is based on the functional diversity, which is the complementto the species diversity. In the tropical rain forest, the saplings grow in the dense and stratifiedunderstorey. This thesis deals with the diversity of realisation of the support function by thesaplings in this context. The hypotheses are that the race through higher and so brighter levelsconstrains the mechanical security of the saplings with necessary biomass saving and need ofreorientation (gravitropism) and acclimation (mecanoperception and response) processes andthat diversity is thus structured by the species light-demand and affinity for the risk. Using awide sample of 16 species, at the Paracou station, relevant functional traits - risk of not-selfsupportingand gravitropic performance - are defined through adapted modellings whichcombine trunk shape, biomass distribution and wood properties. The traits values varybetween species and also with ontogeny and saplings environment. These variations are dueto elementary traits (shape, biomass, wood) with strong geometrical effects. The less selfsupportingspecies (low mechanical security) have the highest gravitropic performances andare also the most light-demanders. A species, Tachigali melinonii, distinguishes itself bystrong slendernesses and a frequent not-self-supporting habit letting suppose a strongadaptability to its mechanical environment. An experiment (growth response to staking),however, did not provide the expected results whereas the species with lower risks, Dicoryniaguianensis, reacted more.
Le fonctionnement des écosystèmes repose sur la diversité fonctionnelle, complément de ladiversité spécifique. En forêt tropicale humide, les jeunes arbres croissent en sous-bois denseet stratifié. Cette thèse porte sur la diversité de réalisation de la fonction biomécanique desoutien. Les hypothèses sont que la "course" vers les strates plus éclairées contraint lasécurité mécanique des jeunes arbres, avec de nécessaires économies de matière et recours àdes processus de réparation (gravitropisme) et d'acclimatation (mécanoperception et réponse),et que la diversité est donc structurée par le besoin en lumière et l'affinité pour le risque desespèces. Avec un échantillon de 16 espèces sur le dispositif de Paracou, des traits fonctionnelspertinents - risque de non-autoportance et performance gravitropique - sont définis au traversde modélisations adaptées qui combinent forme des troncs, répartition des masses etpropriétés du bois. Ces traits varient entre espèces mais aussi avec le développement etl'environnement des arbres. Ces variations sont dues aux variations des traits élémentaires(forme, masses, bois) avec de forts effets géométriques. Les espèces les moins autoportantes(faible sécurité) ont les plus fortes performances gravitropiques. Ce sont aussi les plusdemandeuses de lumière. Une espèce Tachigali melinonii se distingue par de fortsélancements et une fréquente non-autoportance laissant supposer une adaptabilité forte àl'environnement mécanique. Une expérimentation (réponse de croissance au tuteurage) n'acependant pas abouti aux résultats supposés puisque c'est au contraire l'espèce à faible risque,Dicorynia guianensis, qui s'est montrée plus réactive.
https://tel.archives-ouvertes.fr/tel-00272100

tel-00272100
https://tel.archives-ouvertes.fr/tel-00272100
https://tel.archives-ouvertes.fr/tel-00272100/document
https://tel.archives-ouvertes.fr/tel-00272100/file/TheseJaouen.pdf

Éditeur(s) : HAL CCSD
Résumé : International audience
Objective: The objective of this study was to identify the factors associated with presentation for care with CD4 cell count <200/mm3. Design: A Retrospective monocentric cohort study of the Guadeloupe section of French Hospital Database for HIV was conducted. Methods: Group 1 Cohort (CD4 <200/mm3, n=1076), Group 2 (CD4 200-500, n=973) and Group 3 (CD4 >≥ 500/ mm3, n=627) patients were included between 1 January 1988 and 31 December 2009. Factors associated with late presentation (CD4 count <200 cells/μL) were assessed using descriptive statistics and ordered multivariable logistic regression. Results: At the time of diagnosis, 40.21% of patients had than less 200 CD4 lymphocytes/mm3. Age older than 30 years OR: 1.55[1.14-2.10], p=0.005, male gender OR: 1.83[1.58-2.12], p<0.0001, access to care before 1992 OR: 1.56[1.03-2.02], p=0.038 and alcohol use OR: 8.80[2.26-34.36], p=0.002 were independently associated with a low CD4 cell count. Conclusion: The findings of this study (underline the need to expand HIV testing beyond the usual facilities) may be of value in helping to achieve earlier access to treatment in HIV-infected patients in order to minimize the individual risk of morbidity and mortality.
J AIDS Clinic Res

inserm-00915176
http://www.hal.inserm.fr/inserm-00915176
http://www.hal.inserm.fr/inserm-00915176/document
http://www.hal.inserm.fr/inserm-00915176/file/2012_Elenga_-_Risk_Factors_for_Late_Presentation_for_Care_among_HIV-Infected_Patients_in_guadeloupe_1988_2009.pdf
DOI : 10.4172/2155-6113.1000166

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
Background: Despite intensive research over several decades, the etiology of multiple sclerosis (MS) remains poorly understood, although environmental factors are supposedly implicated. Our goal was to identify spatial clusters of MS incident cases at the small-area level to provide clues to local environmental risk factors that might cause or trigger the disease. Methods: A population-based and multi-stage study was performed in the French Brittany region to accurately ascertain the clinical onset of disease during the 2000-2004 period. The municipality of residence at the time of clinical onset was geocoded. To test for the presence of MS incidence clusters and to identify their approximate locations, we used a spatial scan statistic. We adjusted for socioeconomic deprivation, known to be strongly associated with increased MS incident rates, and scanned simultaneously for areas with either high or low rates. Sensitivity analyses (focusing on relapsing-remitting forms and/or places of residence available within the year following clinical onset) were performed. Results: A total of 848 incident cases of MS were registered in Brittany, corresponding to a crude annual incidence rate of 5.8 per 100,000 inhabitants. The spatial scan statistic did not find a significant cluster of MS incidence in either the primary analysis (p value >= 0.56) or in the sensitivity analyses (p value >= 0.16). Conclusion: The findings of this study indicate that MS incidence is not markedly affected across space, suggesting that in the years preceding the first clinical expression of the disease, no environmental trigger is operative at the small-area population level in the French Brittany region.
ISSN: 1476-072X

hal-01616063
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01616063
DOI : 10.1186/s12942-017-0108-6
PUBMED : 28934989