Éditeur(s) : HAL CCSD
Résumé : International audience
Despite their dynamic nature, certain chromatin marks must be maintained over the long term. This is particulary true for histone 3 lysine 9 (H3K9) trimethylation, that is involved in the maintenance of healthy differentiated cellular states by preventing inappropriate gene expression, and has been recently identified as the most efficient barrier to cellular reprogramming in nuclear transfer experiments. We propose that the capacity of the enzymes SUV39H1/2 to rebind to a minor fraction of their products, either directly or via HP1α/β, contributes to the solidity of this mark through (i) a positive feedback involved in its establishment by the mutual enforcement of H3K9me3 and SUV39H1/2 and then (ii) a negative feedback sufficient to strongly stabilize H3K9me3 heterochromatin in post-mitotic cells by generating local enzyme concentrations capable of counteracting transient bursts of demethylation. This model does not require direct molecular interactions with adjacent nucleosomes and is favoured by a series of additional mechanisms including (i) the protection of chromatin-bound SUV39H1/2 from the turnovers of soluble proteins, which can explain the uncoupling between the cellular contents in SUV39H1 mRNA and protein; (ii) the cooperative dependence on the local density of the H3K9me3 of HP1α/β-dependent heterochomatin condensation and, dispensably (iii) restricted enzyme exchanges with chromocenters confining the reactive bursts of SUV39H1/2 in heterochromatin. This mechanism illustrates how seemingly static epigenetic states can be firmly maintained by dynamic and reversible modifications. © 2016 Elsevier B.V.
Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

hal-01467548
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01467548
DOI : 10.1016/j.bbagrm.2016.11.006
PUBMED : 27876670

Éditeur(s) : HAL CCSD Wiley-Blackwell
Résumé : International audience
We mainly study a system of two coupled nonlinear Schrödinger equations where one equation includes gain and the other one includes losses. This model constitutes a generalization of the model of pulse propagation in bire-fringent optical fibers. We answered partially to a question of some authors in [8], that in the Manakov case, the solution stays in L 2 (0, T ; H 1), that means that the solution can not blow up in finite time. More precisely, the bound that is provided in this paper does not seem to be optimal but different than those that has been given from a previous study [8]. Thanks to the way we treat the a priori estimate, we obtain a sharp bound in L 2 (0, T ; H 1), which would be difficult to reach from the study of other authors [8]. The result is illustrated by numerical results which have been obtained with a finite element solver well adapted for that purpose.
ISSN: 0022-2526

Droits : http://creativecommons.org/licenses/by/
hal-01270459
https://hal.archives-ouvertes.fr/hal-01270459
https://hal.archives-ouvertes.fr/hal-01270459/document
https://hal.archives-ouvertes.fr/hal-01270459/file/paperver2.pdf

Éditeur(s) : HAL CCSD Trans Tech Publications Inc.
Résumé : Two, high purity, Al-0.1 and 0.3wt%Mn alloys have been cold deformed in plane strain compression to strains of order 1.8 and the kinetics of subsequent recovery by sub-grain coarsening during annealing at 150-300°C measured by high resolution FEG-SEM EBSD. Accurate sub-grain size and misorientation distributions and their evolution with time and temperature have been determined. The average growth rates are then used to estimate the sub-grain boundary mobilities. Growth is analyzed by two well-known growth laws for the average sub-grain size δ (t): i) the standard relation for grain growth: where the exponent n takes values of 2-8 and ii) the relation proposed by Nes for dislocation climb in sub-grain walls: It is shown that the latter relation gives a better fit with the data in terms of the time and temperature dependence of the sub-grain sizes. In particular the activation energies for the logarithmic law are much closer to the values expected for solute-controlled movement of sub-boundaries.
Materials Science Forum

hal-00795441
https://hal.archives-ouvertes.fr/hal-00795441
DOI : 10.4028/www.scientific.net/MSF.715-716.725

Éditeur(s) : HAL CCSD American Chemical Society
Résumé : International audience
The 90-kDa heat shock protein (Hsp90) is a highly flexible dimer able to self-associate in the presence of divalent cations or under heat shock. This study investigated the relationship between Hsp90 oligomers and the Hsp90 cochaperone Aha1 (activator of Hsp90 ATPase). The interactions of Aha1 with Hsp90 dimers and oligomers were evaluated by ultracentrifugation, size-exclusion chromatography coupled to multiangle laser light scattering and high-mass matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Hsp90 dimer was able to bind up to four Aha1 molecules, and Hsp90 oligomers are also able to interact with Aha1. The binding of Aha1 did not interfere with the Hsp90 oligomerization process. Except for Hsp90 dimer, the stoichiometry of the interaction remained constant, at 2 Aha1 molecules per Hsp90 dimer, regardless of the degree of Hsp90 oligomerization. Moreover, Aha1 predominantly bound to Hsp90 oligomers. Thus, the ability of Hsp90 oligomers to bind the Aha1 ATPase activator reinforces their role within the Hsp90 chaperone machineries
ISSN: 0003-2700

hal-01175535
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01175535
DOI : 10.1021/acs.analchem.5b00051
PUBMED : 26076190

Éditeur(s) : Université Européenne de Bretagne
Résumé : The southwest Pacific results from the fragmentation of Gondwanaland since the Cretaceous time. The purpose of the current PhD work is to deepen our understanding of the history of the New Caledonia and Fairway basins, located west of New Caledonia, in order to better constrain the geodynamical evolution of the SW Pacific from Cretaceous to Oligocene. The analysis of new geophysical data has led to distinguish 3 main phases of this fragmentation: 1 Mid Cretaceous formation of the Fairway-Aotea Basin in a continental intra-arc position. The formation of this basin reflects the initial stage of continental fragmentation of the Eastern Gondwana margin. The causes of this fragmentation are to be searched for in a major change of the dynamics of the peri-Pacific subduction zone. 2 Latest late Eocene local deformation of the Northern NCB, synchronously with the New Caledonian obduction. We suggest that as the ophiolitic nappe was being obducted onto New Caledonia, the NC Basin subsided under the effect of the loading and underthrusted to accommodate the compressional deformation as a foreland flexural basin. 3 Regional Eocene Oligocene subsidence of the structures linking NC to New Zealand. The morphostructural style of this deformation leads us to suggest that detachment of the lower crust is the cause of subsidence. We therefore propose a model in which the renewal of the Australia-Pacific convergent plate boundary around 45 Ma would have driven the lithosphere to thicken, leading to a root instability and to its detachment in the mantle. These new results have regional petroleum implications, which are discussed in the PhD.
Le Sud-Ouest Pacifique est le résultat de la fragmentation de la marge Est du Gondwana depuis le Crétacé. L'objet du présent travail de thèse est d'approfondir la connaissance des bassins de Nouvelle-Calédonie et de Fairway, situés à l'Ouest de la NC, afin de préciser l'évolution géodynamique du SO Pacifique du Crétacé à l'Oligocène. L'analyse de nouvelles données géophysiques a permis de dégager 3 étapes de cette fragmentation: 1 Formation du Bassin de Fairway-Aotea au Crétacé moyen en position intra-arc continental. La formation de ce bassin reflète les prémices de la déchirure continentale de la marge Est Gondwanienne dont la cause est à rechercher dans un changement de la dynamique de la subduction. 2 Déformation locale de la partie Nord du BNC à l'Eocène terminal synchrone à l'obduction Néo Calédonienne. Nous proposons ainsi un modèle selon lequel le BNC aurait subsidé et réagi comme un bassin flexural d'avant-pays suivant un processus de sous-charriage, au fur et à mesure que la nappe progressait sur le bâti Calédonien. 3 Subsidence Eocène Oligocène régionale affectant les structures reliant la Nouvelle-Zélande à la NC. Les traits morphostructuraux de cette déformation nous permettent d'émettre l'hypothèse que l'ablation d'une partie de la croûte inférieure de ce système serait responsable de la subsidence. Nous proposons ainsi un modèle dans lequel la reprise de la convergence vers 45 Ma entre les plaques Australienne et Pacifique aurait entraîné un épaississement crustal de l'ensemble aboutissant à une instabilité gravitaire de sa racine et provoquant son détachement dans le manteau. Ces nouveaux résultats ont des implications pour le potentiel pétrolier régional.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/2009/these-6520.pdf
http://archimer.ifremer.fr/doc/2009/sup-6520.pdf
http://archimer.ifremer.fr/doc/00000/6520/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Fault affecting silicoclastic sediments are commonly enriched in clay minerals. Clays are sensitive to fluid–rock interactions and deformation mechanisms; in this paper, they are used as proxy for fault activity and behavior. The present study focuses on clay mineral assemblages from the Point Vert normal fault zone located in the Annot sandstones, a Priabonian-Rupelian turbidite succession of the Alpine foredeep in SE France. In this area, the Annot sandstones were buried around 6–8 km below the front of Alpine nappes soon after their deposition and exhumed during the middle-late Miocene. The fault affects arkosic sandstone beds alternating with pelitic layers, and displays throw of about thirty meters. The fault core zone comprises intensely foliated sandstones bounding a corridor of gouge about 20 cm thick. The foliated sandstones display clay concentration along S–C structures characterized by dissolution of K-feldspar and their replacement by mica, associated with quartz pressure solution, intense microfracturation and quartz vein precipitation. The gouge is formed by a clayey matrix containing fragments of foliated sandstones and pelites. However, a detailed petrographical investigation suggests complex polyphase deformation processes. Optical and SEM observations show that the clay minerals fraction of all studied rocks (pelites and sandstones from the damage and core zones of the fault) is dominated by white micas and chlorite. These minerals have two different origins: detrital and newly-formed. Detrital micas are identified by their larger shape and their chemical composition with a lower Fe–Mg content than the newly-formed white micas. In the foliated sandstones, newly-formed white micas are concentrated along S–C structures or replace K-feldspar. Both types of newly formed micas display the same chemical composition confirmed microstructural observations suggesting that they formed in the same conditions. They have the following structural formulas: Na0.05 K0.86 (Al 1.77 Fe0.08 Mg0.15) (Si3.22 Al0.78) O10 (OH)2. They are enriched in Fe and Mg compared to the detrital micas. Newly-formed chlorites are associated with micas along the shear planes. According to microprobe analyses, they present the following structural formula: (Al1,48 Fe2,50 Mg1,84) (Si2,82 Al1,18) O10 (OH)8. All these data suggest that these clay minerals are synkinematic and registered the fault activity. In the gouge samples, illite and chlorite are the major clay minerals; smectite is locally present in some samples.In the foliated sandstones, Kubler Index (KI) ((001) XRD peak width at half height) data and thermodynamic calculations from synkinematic chlorite chemistry suggest that the main fault deformation occurred under temperatures around 220 °C (diagenesis to anchizone boundary). KI measured on pelites and sandstones from the hanging and footwall, display similar values coherent with the maximal burial temperature of the Annot sandstones in this area. The gouge samples have a higher KI index, which could be explained by a reactivation of the fault at lower temperatures during the exhumation of the Annot sandstones formation
ISSN: 0191-8141

hal-01172423
https://hal.archives-ouvertes.fr/hal-01172423
DOI : 10.1016/j.jsg.2015.03.012

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
We study if the multilevel algorithm introduced by Debussche, T. Dubois and R. Temam [Theoret. Comput. Fluid Dynam. 7 (1995), no. 4, 279-315; Zbl 838.76060] and Dubois, F. Jauberteau and Temam [J. Sci. Comput. 8 (1993), no. 2, 167-194; MR1242960 (94f:65098)] for the 2D Navier-Stokes equations with periodic boundary conditions and spectral discretization can be generalized to more general boundary conditions and to finite elements. We first show that a direct generalization, as in [C. Calgaro, J. Laminie and R. Temam, Appl. Numer. Math. 23 (1997), no. 4, 403-442; MR1453424 (98d:76124)], for the Burgers equation, would not be very efficient. We then propose a new approach where the domain of integration is decomposed into subdomains. This enables us to define localized small-scale components and we show that, in this context, there is a good separation of scales. We conclude that all the ingredients necessary for the implementation of the multilevel algorithm are present.
ISSN: 0271-2091

hal-00730709
https://hal.archives-ouvertes.fr/hal-00730709

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
The Iberian Massif is the best exposed segment of the European Variscan Belt. It includes relatively well preserved terranes that were accreted by transpression along time and resulted in a number of geotectonic units that formed part of the Late Paleozoic assembly of the Pangaea Supercontinent. In SW Iberia, these units are the Central Iberian Zone (CIZ), Ossa Morena Zone (OMZ), and the South Portuguese Zone (SPZ). A 210 km long NE-SW magnetotelluric profile was carried out through the CIZ, from the OMZ-CIZ boundary toward the north, reaching the Tagus (Cenozoic) basin. Data dimensionality analysis resulted in a suitable 2-D electrical resistivity structure, allowing a 2-D inversion of the data set. Complementary available geophysical data (deep seismic, gravity and aeromagnetic) and a comparison with a detailed geological cross section led us to constrain the interpretation of the 2-D electrical resistivity structure of the CIZ crust. The results show, for the upper crust, the existence of diverse conductive/resistive bodies that correlate well with known geological features (sedimentary basins, faults, granitic plutons, mineralized systems). A mild but steady conductive band is located along the middle and lower crust that is interpreted as a mafic granulite basement. The upper section of this band connects with several elongated shallow conductors, providing further evidence for the existence, in the Central Iberian Zone, of a complex decollement system where the major faults are rooted. Such a crustal architecture is viewed as the northward continuation of the Variscan large-scale structures previously recognized in the southern sectors (OMZ and SPZ).
ISSN: 0148-0227

hal-00671036
https://hal.archives-ouvertes.fr/hal-00671036
DOI : 10.1029/2010JB007538

Éditeur(s) : Elsevier
Résumé : We present results from multibeam bathymetric data acquired during 2005 and 2006, in the region of maximum slip of the 26 Dec. 2004 earthquake (Mw 9.2). These data provide high-resolution images of seafloor morphology of the entire NW Sumatra forearc from the Sunda trench to the submarine volcanic arc just north of Sumatra. A slope gradient analysis of the combined dataset accurately highlights those portions of the seafloor shaped by active tectonic, depositional and/or erosional processes. The greatest slope gradients are located in the frontal 30 km of the forearc, at the toe of the accretionary wedge. This suggests that long-term deformation rates are highest here and that probably only minor amounts of slip are accommodated by other thrust faults further landward. Obvious N-S oriented lineaments observed on the incoming oceanic plate are aligned sub-parallel to the fracture zones associated with the Wharton fossil spreading center. Active strike-slip motion is suggested by recent deformation with up to 20-30 m of vertical offset. The intersection of these N-S elongated bathymetric scarps with the accretionary wedge partly controls the geometry of thrust anticlines and the location of erosional features (e.g. slide scars, canyons) at the wedge toe. Our interpretation suggests that these N-S lineaments have a significant impact on the oceanic plate, the toe of the wedge and further landward in the wedge. Finally, the bathymetric data indicate that folding at the front of the accretionary wedge occurs primarily along landward-vergent (seaward-dipping) thrusts, all unusual style in accretionary wedges worldwide. The N-S elongated lineaments locally act as boundaries between zones with predominant seaward versus landward vergence.
Earth and Planetary Science Letters (0012-821X) (Elsevier), 2008-11 , Vol. 275 , N. 3-4 , P. 201-210

Droits : 2008 Elsevier B.V. All rights reserved.
http://archimer.ifremer.fr/doc/2008/publication-5166.pdf
DOI:10.1016/j.epsl.2008.04.053
http://archimer.ifremer.fr/doc/00000/5166/

Éditeur(s) : HAL CCSD AGU and the Geochemical Society
Résumé : International audience
The transition between the small melt lens observed on top of fast spreading ridge magma chambers and the overlying sheeted dike complex marks the interface between magma and the hydrothermal convective system. It is therefore critical to our understanding of fast spreading ridge accretion processes. We present maps of two areas of the Oman ophiolite where this transition zone is observed as continuous outcrops. Our observations, which include the base of the sheeted dike being crosscut by gabbros, are consistent with episodic dike injections in a steady state model but also suggest that the root of these dikes is commonly erased by vertical movements of the top of the melt lens. Dike assimilation is a possible mechanism for incorporating hydrated phases, which result from hydrothermal alteration, to the melt lens during upward migrations of its upper boundary. Upward migrations are also responsible for a granoblastic overprint of the root of the dikes that is also observed in the stoped diabase xenoliths. This granoblastic overprint attests to reheating of previously hydrothermally altered lithologies which can even trigger hydrous partial melting due to the lowering of the solidus of mafic lithologies by the presence of a water activity. Clinopyroxenes present in these granoblastic lithologies are typically low in Ti and Al content, thus strongly contrasting with corresponding magmatic clinopyroxene. This may attest to the recrystallization of clinopyroxenes after amphiboles under the peculiar conditions present at the root zone of the sheeted dike complex. Downward migrations of the top of the melt lens result in the crystallization of the isotropic gabbros at its roof, which represent the partly fossilized melt lens. Melt lens fossilization eventually occurs when magma supply is stopped or at the melt lens margins where the thermal conditions become cooler. Melt lens migration, recrystallization of hydrothermally altered sheeted dikes during reheating stages, and assimilation processes observed in the Oman ophiolite are consistent with the observations made in IODP Hole 1256D. We propose a general dynamic model in which the melt lens at fast spreading ridges undergoes upward and downward movements as a result of either eruption/replenishment stages or variations in the hydrothermal/magmatic fluxes.
ISSN: 1525-2027

hal-00445249
https://hal.archives-ouvertes.fr/hal-00445249
DOI : 10.1029/2009GC002652

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
In the mid-afternoon of 15 July 2007, during the Convective and Orographically induced Precipitation Study (COPS), in a very warm and dry environment, an isolated, short-lived, deep convective system developed over the southern Black Forest. Most of the high-resolution, convection-permitting models involved in COPS were unable to capture this event whereas the Meso-NH forecast was quite skilful. To assess the Meso-NH performance further, the model results were carefully checked against the various and numerous COPS observations. In full agreement with clear-air radar observations, model results underlined the triggering role of a low-level convergence line that developed in the lee of the Feldberg. The main departure from the observations was found to be in the low-level moisture fields, which appeared significantly moister in the model than in the observations and also slightly moister than in the other models. Sensitivity studies showed that this departure from the observations was strongly controlled by the initial surface moisture conditions. When the surface moisture was reduced by 20% or replaced by the value derived from a different analysis, the evolution of the planetary boundary layer was more accurately represented while the storm evolution was still correctly captured. These results demonstrate that the quality of the initial forecast cannot be ascribed to the moist bias of the model. It could therefore be hypothesized that the key parameters for a satisfactory forecast of this event lie more in the ability of the model to reproduce the dynamical forcing accurately than in the characteristics of the air-mass instability.
ISSN: 0035-9009

hal-00554400
https://hal.archives-ouvertes.fr/hal-00554400
DOI : 10.1002/qj.710

Éditeur(s) : American Geophysical Union
Résumé : The Fairway Ridge is a buried continental structure that separates the Fairway Basin from the New Caledonia Basin. The proposed Cretaceous age of the Fairway Basin has remained highly hypothetical to date. Deep offshore petroleum exploration wells revealed well-dated Mesozoic carbonaceous sedimentary rocks in the Taranaki Basin at the southern end of the Aotea Basin. In this paper we use geophysical data to confirm the continuity of the 2000 km long Fairway-Aotea Basin connecting New Caledonia to New Zealand and prove its early Late Cretaceous age. Analysis of seismic reflection profiles together with newly compiled gravity and magnetic maps reveals Late Cretaceous NE–SW trending lineaments projecting northeastward from major Tasman Sea fracture zones and the Bellona Trough, which demonstrate that the opening of the Fairway-Aotea Basin predates the opening of the Tasman Sea. This result combined with observations of the Mesozoic regional geology suggests that the Lord Howe, Fairway, and Norfolk ridges are part of a remnant late Early Cretaceous continental arc, which was fragmented into three pieces by the late Early to early Late Cretaceous. This event might be contemporaneous with a plate motion change between the Gondwana and Pacific plates and/or the arrival of the Hikurangi plateau in the subduction zone around 105 Ma, which caused the cessation of subduction along this plate boundary. We interpret either of those two events as being possible trigger events for the post–Early Cretaceous fragmentation of the eastern Gondwana margin in a slab retreat process.
Geochemistry Geophysics Geosystems - G3 (1525-2027) (American Geophysical Union), 2009-12 , Vol. 10 , N. 12 , P. 1-24

Droits : 2009 American Geophysical Union
http://archimer.ifremer.fr/doc/2009/publication-7322.pdf
DOI:10.1029/2009GC002612
http://archimer.ifremer.fr/doc/00000/7322/

Éditeur(s) : HAL CCSD
Résumé : International audience
Some research on written production has focused on the role of the syllable as a processing unit. However, the precise nature of this syllable unit has yet to be elucidated. The present study examined whether the nature of this processing unit is orthographic (i.e., the ortho-syllable) or phonological. Thirty-two native French speakers were asked to copy adjectives on a digitizer, successively adding a plural and a feminine one-letter morpheme to the same adjective. The adjective agreement could modify the structure of both phonological and orthographic syllables, only ortho-syllabic structure, or leave both unchanged. When the change modified only the orthographic syllable structure, there was an increase in duration at the letter before the syllable boundary. By contrast, when adding a letter changed both orthographic and phonological structures, an increase in the duration of the inter-letter interval was observed. Importantly, the increase in duration cannot be explained exclusively by the addition of a letter because the addition of a plural inflection did not significantly influence the dynamics of handwritten production. These results are consistent with the idea that ortho-syllables serve as a processing unit during handwriting, and that this type of syllable is specific to the written code.
17th Biennial Conference of the International Graphonomics Society
Pointe-à-Pitre, Guadeloupe

hal-01165879
https://hal.univ-antilles.fr/hal-01165879
https://hal.univ-antilles.fr/hal-01165879/document
https://hal.univ-antilles.fr/hal-01165879/file/IGS_2015_submission_14.pdf

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : We study the Africa-Iberia plate boundary in the vicinity of Gibraltar. Numerous models have been proposed for that region throughout the last decades, proposing mechanisms that range widely from continental delamination, convective removal, to subduction of oceanic lithosphere. To better constrain upper-mantle structure under the region, we study waveforms of P-waves that traverse the Alboran Sea region between Spain and Morocco. These show dispersive behavior, which, together with early arrival times, confirms the presence of an anomalous upper mantle structure under the Alboran Sea. The dispersion is consistent with that expected from subducted lithosphere. Waveforms of body waves therefore provide a way to better constrain the elusive mantle structure and dynamics of the Alboran Sea region
ISSN: 0094-8276

hal-00407670
https://hal.archives-ouvertes.fr/hal-00407670
DOI : 10.1029/2007GL030964

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
We investigate upper mantle anisotropy beneath the Pyrenean range along three N-S profiles across the mountain belt. The results of a first profile that operated in 1993 in the central part of the belt have been presented elsewhere. We present the results of two other profiles that ran in 1995-1996 and 1996-1997 in the eastern and western part of the belt, respectively and propose an interpretation of the whole results. Teleseismic shear waves (SKS, SKKS, and PKS) are used to determine splitting parameters: the fast polarization direction φ and the delay time δt. Teleseismic shear wave splitting in the eastern Pyrenees displays homogeneous φ values trending N100°E and δt values in the range 1.1 to 1.5 s. A station located in the southern Massif Central, 100 km north of the range, is characterized by different splitting parameters (φ = N70°E, δt = 0.7 s). In the western part of the belt, anisotropy parameters are similar across the whole belt (φ = N110°E and δt = 1.3 to 1.5 s). Most of the measured delay times, including those obtained in the central part of the range, are above the global average of the SKS splitting (around 1 s). At the belt scale, φ is generally poorly correlated with recent estimations of the absolute plate motion, which predicts a fast direction ranging between N50°E and N80°E. Instead, the orientation of φ (N100°E) is parallel to the trend of the Pyrenean belt but also to Hercynian preexisting structures. This parallelism supports an anisotropy primarily related to frozen or active lithospheric structures. We show that a signature related to the Pyrenean orogeny is likely for the stations located in the internal domains of the belt. By contrast, the anisotropy measured at the stations located on the external parts of the belt could reflect a pre-Pyrenean (Hercynian) deformation. We suggest that a late Hercynian strike-slip deformation is responsible for this frozen upper mantle anisotropy and that the Pyrenean tectonic fabric developped parallel to this preexisting fabric. Finally, no particularly strong splitting is related to the North Pyrenean Fault, commonly believed to represent the plate boundary between Iberia and Eurasia.
ISSN: 2169-9313

hal-01388841
http://hal.univ-reunion.fr/hal-01388841
http://hal.univ-reunion.fr/hal-01388841/document
http://hal.univ-reunion.fr/hal-01388841/file/Barruol_Aniso_Pyr_JGR1998.pdf
DOI : 10.1029/98JB02790

Éditeur(s) : HAL CCSD
Résumé : International audience
Astrocytes send out long processes that are terminated by endfeet at the vascular surface and regulate vascular functions as well as homeostasis at the vascular interface. To date, the astroglial mechanisms underlying these functions have been poorly addressed. Here we demonstrate that a subset of messenger RNAs is distributed in astrocyte endfeet. We identified, among this transcriptome, a pool of messenger RNAs bound to ribosomes, the endfeetome, that primarily encodes for secreted and membrane proteins. We detected nascent protein synthesis in astrocyte endfeet. Finally, we determined the presence of smooth and rough endoplasmic reticulum and the Golgi apparatus in astrocyte perivascular processes and endfeet, suggesting for local maturation of membrane and secreted proteins. These results demonstrate for the first time that protein synthesis occurs in astrocyte perivascular distal processes that may sustain their structural and functional polarization at the vascular interface.
Cell Discovery

hal-01545319
https://hal.archives-ouvertes.fr/hal-01545319
DOI : 10.1038/celldisc.2017.5

Éditeur(s) : HAL CCSD
Résumé : International audience
This paper aims to demonstrate that the use of a modern tool, the GPS (Global PositioningSystem), can significantly improve our understanding of active faults and their seismic cycle. We focus on theNorth-Caribbean plate boundary, specifically in the Dominican Republic, and present some quantificationsof velocities that result from measurements that have been made possible by the instrumentation of the areaby a consortium of researchers from France, the USA and the Dominican Republic, since 1994. Then, wediscuss the velocities in terms of seismic potential of the regional major faults.
Cet article présente comment l'utilisation d'un outil moderne, le GPS (Global Positioning System) peut apporter des éléments significatifs dans la connaissance des failles actives et de leur cycle sismique. Nous nous intéressons ici à la frontière de plaque Nord-Caraibe, en République Dominicaine, et présentons des quantifications de vitesses de déplacement obtenues grâce à l'instrumentation de la zone depuis 1994 par un groupe de chercheurs français, états-uniens et dominicains. Les résultats sont ensuite discutés en termes d'aléas sismologiques des failles majeures.
ISSN: 2551-6116

hal-01537725
https://hal.univ-antilles.fr/hal-01537725
https://hal.univ-antilles.fr/hal-01537725/document
https://hal.univ-antilles.fr/hal-01537725/file/Mazabraud-et-Forissier-2007.pdf

Éditeur(s) : HAL CCSD Elsevier
Résumé : Hot collisional orogens are characterized by abundant syn-kinematic granitic magmatism that profoundly affects their tectono-thermal evolutions. Voluminous granitic magmas, emplaced between 360 and 270 Ma, played a visibly important role in the evolution of the Variscan Orogen. In the Limousin region (western Massif Central, France), syntectonic granite plutons are spatially associated with major strike-slip shear zones that merge to the northwest with the South Armorican Shear Zone. This region allowed us to assess the role of magmatism in a hot transpressional orogen. Microstructural data and U/Pb zircon and monazite ages from a mylonitic leucogranite indicate synkinematic emplacement in a dextral transpressional shear zone at 313 +/- 4 Ma. Leucogranites are coeval with cordierite-bearing migmatitic gneisses and vertical lenses of leucosome in strike-slip shear zones. We interpret U/Pb monazite ages of 315 +/- 4 Ma for the gneisses and 316 +/- 2 Ma for the leucosomes as the minimum age of high-grade metamorphism and migmatization respectively. These data suggest a spatial and temporal relationship between transpression, crustal melting, rapid exhumation and magma ascent, and cooling of high-grade metamorphic rocks.;Some granites emplaced in the strike-slip shear zone are bounded at their roof by low dip normal faults that strike N-S, perpendicular to the E-W trend of the belt. The abundant crustal magmatism provided a low-viscosity zone that enhanced Variscan orogenic collapse during continued transpression, inducing the development of normal faults in the transpression zone and thrust faults at the front of the collapsed orogen.
ISSN: 0040-1951

hal-00445260
https://hal.archives-ouvertes.fr/hal-00445260
DOI : 10.1016/j.tecto.2009.03.022

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
The Hedgehog (Hh) family of secreted proteins act as morphogens to control embryonic patterning and development in a variety of organ systems. Post-translational covalent attachment of cholesterol and palmitate to Hh proteins are critical for multimerization and long range signaling potency. However, the biological impact of lipid modifications on Hh ligand distribution and signal reception in humans remains unclear. In the present study, we report a unique case of autosomal recessive syndromic 46,XY Disorder of Sex Development (DSD) with testicular dysgenesis and chondrodysplasia resulting from a homozygous G287V missense mutation in the hedgehog acyl-transferase (HHAT) gene. This mutation occurred in the conserved membrane bound O-acyltransferase (MBOAT) domain and experimentally disrupted the ability of HHAT to palmitoylate Hh proteins such as DHH and SHH. Consistent with the patient phenotype, HHAT was found to be expressed in the somatic cells of both XX and XY gonads at the time of sex determination, and Hhat loss of function in mice recapitulates most of the testicular, skeletal, neuronal and growth defects observed in humans. In the developing testis, HHAT is not required for Sertoli cell commitment but plays a role in proper testis cord formation and the differentiation of fetal Leydig cells. Altogether, these results shed new light on the mechanisms of action of Hh proteins. Furthermore, they provide the first clinical evidence of the essential role played by lipid modification of Hh proteins in human testicular organogenesis and embryonic development.
ISSN: 1553-7390

hal-01063929
https://hal.archives-ouvertes.fr/hal-01063929
DOI : 10.1371/journal.pgen.1004340
PUBMED : 24784881

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
Large earthquakes nucleate at tectonic plate boundaries, and their occurrence within a plate's interior remains rare and poorly documented, especially offshore. The two large earthquakes that struck the northeastern Indian Ocean on 11 April 2012 are an exception: they are the largest strike-slip events reported in historical times1, 2 and triggered large aftershocks worldwide3. Yet they occurred within an intra-oceanic setting along the fossil fabric of the extinct Wharton basin, rather than on a discrete plate boundary4, 5, 6, 7, 8. Here we show that the 11 April 2012 twin earthquakes are part of a continuing boost of the intraplate deformation between India and Australia that followed the Aceh 2004 and Nias 2005 megathrust earthquakes, subsequent to a stress transfer process recognized at other subduction zones9, 10. Using Coulomb stress change calculations, we show that the coseismic slips of the Aceh and Nias earthquakes can promote oceanic left-lateral strike-slip earthquakes on pre-existing meridian-aligned fault planes. We further show that persistent viscous relaxation in the asthenospheric mantle several years after the Aceh megathrust explains the time lag between the 2004 megathrust and the 2012 intraplate events. On a short timescale, the 2012 events provide new evidence for the interplay between megathrusts at the subduction interface and intraplate deformation offshore. On a longer geological timescale, the Australian plate, driven by slab-pull forces at the Sunda trench, is detaching from the Indian plate, which is subjected to resisting forces at the Himalayan front6, 8, 11.
ISSN: 0028-0836

hal-00767569
https://hal.archives-ouvertes.fr/hal-00767569
DOI : 10.1038/nature11520