Résumé : With the histological techniques used to study Heteropod 13, 14 larvae, the histological structures of planktonic larvae are described at a stage close to metamorphosis; species are chosen among families of Mesogastropods (Lamellariidae, Eratoidae, Cypraeidae, Naticidae) whose phylogeny is close to the Atlantacea superfamily (= Heteropoda) according to the Taylor and Sohl15 classification. The mantle, mantle cavity, foot and digestive tract are described in depth.
Avec les techniques histologiques utilisées pour l'étude des larves d'Hétéropodes 13, 14, les structures histologiques des larves planctoniques sont décrites au stade proche de la métamorphose ; les espèces sont choisies parmi les familles de Mésogastropodes (Lamellariidae, Eratoidae, Cypraeidae, Naticidae) dont la lignée phylogénique est proche de la superfamille des Atlantacea (= Heteropoda) d'après la classification de Taylor et Sohl15. Le manteau, la cavité palléale, le pied et le tube digestif sont plus particulièrement décrits. [OCR NON CONTRÔLE]
Thalassia Jugoslavica, 1974 , Vol. 10 , N. 1/2 , P. 379-399

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/1974/publication-5073.pdf
http://archimer.ifremer.fr/doc/00000/5073/

Éditeur(s) : HAL CCSD John Libbey Eurotext
Résumé : International audience
Chemical risk assessment is a tool used in decision-making processes concerning situations of scientific uncertainty. Approaches to risk assessment in occupational and environmental health share the same objective of risk prevention. Nevertheless, the methods for both differ depending on whether the goal is to enforce regulations or conduct expert assessments and studies. These differences are stronger in occupational health, for which regulations require risk assessments at the work station, to classify and prioritize exposure situations to implement occupational risk prevention strategies. Risk assessment thus has somewhat different meanings in occupational and environmental health. This article attempts to clarify the different terms used in the different contexts and to describe the similarities and differences of the two approaches.
ISSN: 1635-0421

hal-00936256
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00936256
DOI : 10.1684/ers.2013.0646

Éditeur(s) : HAL CCSD IWA Publishing
Résumé : International audience
This study proposes a new approach for improving resource quality management, monitoring and treatment plant management, whatever the environmental and climatic stressors. First trend analysis of water quality at a river basin scale, based on historical water quality data and multivariate exploitation (principal component analysis, PCA), led to a classification of the monitoring stations with regard to the main pressures (land use, urbanization and hydroclimatic impacts). This method was applied to the Vilaine's watershed, the largest river basin in Brittany, western France, and one which is under agricultural and urban pressure. A complementary research using a UV index was proposed for the evaluation of spatial and temporal variations of water quality. This approach may be considered as a useful and relevant tool to quickly assess the variation of water quality and the main explanatory factors. It also points out monitoring stations under specific stressors considered as outliers regarding UV parameters. Finally, PCA and UV index give complementary results. PCA allows factors influencing drinking water resource to be highlighted and the UV index allows global water quality under specific times and impacts to be reflected.
Water Science and Technology: Water Supply

hal-00878159
https://hal.archives-ouvertes.fr/hal-00878159
DOI : 10.2166/ws.2012.047

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : 44 pages, 14 figures
International audience
With any non necessarily orientable unpunctured marked surface (S,M) we associate a commutative algebra, called quasi-cluster algebra, equipped with a distinguished set of generators, called quasi-cluster variables, in bijection with the set of arcs and one-sided simple closed curves in (S,M). Quasi-cluster variables are naturally gathered into possibly overlapping sets of fixed cardinality, called quasi-clusters, corresponding to maximal non-intersecting families of arcs and one-sided simple closed curves in (S,M). If the surface S is orientable, then the quasi-cluster algebra is the cluster algebra associated with the marked surface (S,M) in the sense of Fomin, Shapiro and Thurston. We classify quasi-cluster algebras with finitely many quasi-cluster variables and prove that for these quasi-cluster algebras, quasi-cluster monomials form a linear basis. Finally, we attach to (S,M) a family of discrete integrable systems satisfied by quasi-cluster variables associated to arcs in the quasi-cluster algebra and we prove that solutions of these systems can be expressed in terms of cluster variables of type A.
ISSN: 0925-9899

hal-00821878
https://hal.archives-ouvertes.fr/hal-00821878
ARXIV : 1105.1560
DOI : 10.1007/s10801-015-0586-1

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Given a graph, its hyperbolicity is a measure of how close its distance distribution is to the one of a tree. This parameter has gained recent attention in the analysis of some graph algorithms and the classification of complex networks. We study on practical improvements for the computation of hyperbolicity in large graphs. Precisely, we investigate on relations between the hyperbolicity of a graph G and the hyperbolicity of its atoms, that are the subgraphs output by the clique-decomposition invented by Tarjan [51, 65]. We prove that the maximum hyperbolicity taken over the atoms is at most one unit off from the hyperbol-icity of G and the bound is sharp. We also give an algorithm to slightly modify the atoms, called the " substitution method " , which is at no extra cost than computing the clique-decomposition, and so that the maximum hyperbolicity taken over the resulting graphs is exactly the hyperbolicity of the input graph G. An experimental evaluation of our method for computing the hyperbolicity of a given graph from its atoms is provided for collaboration networks and biological networks. Finally, on a more theoretical side, we deduce from our results the first linear-time algorithm for computing the hyperbolicity of an outerplanar graph.
ISSN: 0304-3975

hal-01540756
https://hal.inria.fr/hal-01540756
https://hal.inria.fr/hal-01540756/document
https://hal.inria.fr/hal-01540756/file/CCDL-2017.pdf
DOI : 10.1016/j.tcs.2017.06.001

Éditeur(s) : HAL CCSD
Résumé : International audience
It is an admitted fact that mainstream boosting algorithms like AdaBoost do not perform well to estimate class conditional probabilities. In this paper, we analyze, in the light of this problem, a recent algorithm, unn, which leverages nearest neighbors while minimizing a convex loss. Our contribution is threefold. First, we show that there exists a subclass of surrogate losses, elsewhere called balanced, whose minimization brings simple and statistically efficient estimators for Bayes posteriors. Second, we show explicit convergence rates towards these estimators for unn, for any such surrogate loss, under a Weak Learning Assumption which parallels that of classical boosting results. Third and last, we provide experiments and comparisons on synthetic and real datasets, including the challenging SUN computer vision database. Results clearly display that boosting nearest neighbors may provide highly accurate estimators, sometimes more than a hundred times more accurate than those of other contenders like support vector machines.
European Conference on Machine Learning and Principles and Practice of Knowledge Discovery in Databases (ECML PKDD)
Bristol, United Kingdom

hal-00702771
https://hal.archives-ouvertes.fr/hal-00702771
https://hal.archives-ouvertes.fr/hal-00702771/document
https://hal.archives-ouvertes.fr/hal-00702771/file/ecml12-dnbnb-sub.pdf

Éditeur(s) : HAL CCSD
Résumé : This thesis has been conducted on a fractured crystalline basement located in Ploemeur (South of Brittany, France). The detailed study of this basement requires a good understanding of their internal structures, namely their intrinsic properties, flow mode, density and fractures distribution. This work is focused on the petrophysical characterization of the granitic formations. Physical properties were determined from downhole geophysical measurements and images, and petrophysical measurements with thin sections made for each mini-core in the laboratory. Fresh-altered schist and fresh-altered granite separated by a normal angle fault are the main lithology of the Ploemeur crystalline basement. The results showed that the petrophysical properties were function of both porosity variation and degree of alteration and that the pore-space topology was found to be porositydependent. This thesis introduces a new formula between electrical resistivity and porosity. In addition, the laboratory measurements of Ploemeur revealed that seismic wave velocity was a function not only of porosity, but also of the predominant pore type. In general, the pore aspect ratio inverted from velocity measurements were classified roughly into crack shape. In the Ploemeur crystalline basement, the downhole geophysical measurements and images were used to measure changes in physical and chemical properties in the borehole fluid and the bedrock surrounding the boreholes. The effective integration of different geophysical methods, hydrogeological tests and lithological description was the best way to characterize the fractures in the crystalline basement, and is critical for a suitable estimation of fluid circulation.
Le socle cristallin fracturé, situé à Ploemeur (Bretagne sud, France) est l'objet de ce travail de thèse. L'étude détaillée du socle nécessite une bonne compréhension de la structure interne, à savoir les propriétés intrinsèques, le mode d'écoulement, la densité et la distribution des fractures. Ce travail de thèse est consacré à la caractérisation pétrophysique des formations granitiques. Les propriétés physiques ont été déterminées à partir de l'interprétation des données de mesures de géophysique en forage, des images de paroi du puits et des mesures pétrophysiques réalisées sur carottes en laboratoire. Afin de replacer les mesures dans leur contexte lithologique, une lame mince a été analysée pour chaque mini-carotte. Les formations lithologiques rencontrées dans le socle cristallin de Ploemeur sont des schistes et granites sains et altérés, ces deux lithologies étant séparées par une zone de faille. Les résultats ont montré que les propriétés pétrophysiques des roches étaient fonction à la fois de la variation de la porosité et du degré d'altération des roches et que la topologie de l'espace poreux était fortement dépendante de la porosité. Cette thèse introduit une nouvelle formule entre la résistivité électrique et la porosité. De plus, les mesures en laboratoire sur les échantillons de Ploemeur révèlent que les vitesses sismiques ne sont pas seulement fonction de la quantité de porosité, mais aussi fonction de facteur de forme. Ce dernier a été calculé sur les échantillons du socle de Ploemeur à partir des vitesses acoustiques. Les résultats ont montré que la porosité est de forme fissurale. L'intégration des données issues des images optiques et acoustiques, des mesures de géophysique en forage, et de la description des carottes a permis d'étudier de façon détaillée la géologie et l'hydrodynamique du socle de Ploemeur. L'intégration effective de ces différentes méthodes avec les tests hydrogéologiques ressort comme la meilleure façon de caractériser les fractures et les circulations en eau dans le socle.
https://tel.archives-ouvertes.fr/tel-00444175

Droits : info:eu-repo/semantics/OpenAccess
tel-00444175
https://tel.archives-ouvertes.fr/tel-00444175
https://tel.archives-ouvertes.fr/tel-00444175/document
https://tel.archives-ouvertes.fr/tel-00444175/file/thesebelghoul.pdf

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
Introduction In order to study social health inequalities, contextual (or ecologic) data may constitute an appropriate alternative to individual socioeconomic characteristics. Indices can be used to summarize the multiple dimensions of the neighborhood socioeconomic status. This work proposes a statistical procedure to create a neighborhood socioeconomic index. Methods The study setting is composed of three French urban areas. Socioeconomic data at the census block scale come from the 1999 census. Successive principal components analyses are used to select variables and create the index. Both metropolitan area-specific and global indices are tested and compared. Socioeconomic categories are drawn with hierarchical clustering as a reference to determine "optimal" thresholds able to create categories along a one-dimensional index. Results Among the twenty variables finally selected in the index, 15 are common to the three metropolitan areas. The index explains at least 57% of the variance of these variables in each metropolitan area, with a contribution of more than 80% of the 15 common variables. Conclusions The proposed procedure is statistically justified and robust. It can be applied to multiple geographical areas or socioeconomic variables and provides meaningful information to public health bodies. We highlight the importance of the classification method. We propose an R package in order to use this procedure.
International Journal for Equity in Health

hal-00854028
https://hal.archives-ouvertes.fr/hal-00854028
https://hal.archives-ouvertes.fr/hal-00854028/document
DOI : 10.1186/1475-9276-12-21

Éditeur(s) : HAL CCSD Springer International Publishing
Résumé : International audience
Understanding the formation processes of maritime archaeological sites and the maritime landscape in the French West Indies is a new challenge in underwater archaeology. This chapter presents an analysis of formation and conservation processes of maritime archaeological sites in Guadeloupe using evidence from both historical and archaeological research. Formation parameters include contemporary events associated with maritime loss and the in situ geophysical regime. Questions considered include: what natural and/or anthropogenic parameters best classify maritime sites in the context of the French West Indies landscape? And: how do these parameters vary by site location? Field-tested case studies are used to assess the archaeological potential for submerged shipwreck sites for three locational typologies within the landscape: submerged, coastal, and micro-island. Geomorphic parameters, including erosion, sea level evolution, and tectonic activity, are evaluated with regard to the formation of coastal Amerindian and colonial sites. The location of shipwrecks are primarily determined by historic patterns in commercial trade and by topographical constraints associated with accessibility, risk, and the presence of natural harbors, parameters important in the Caribbean. A unique feature of Guadeloupe is the high variability of the structure of the coastline through time. The recent discovery of numerous underwater prehistoric artifacts confirms that several islands, coastal areas, and their archaeological sites have been completely submerged or eroded since their formation. The characterization of these formation processes provides both academically interesting and practical information valuable in assessing the impact of development and urbanization in Guadeloupe’s maritime landscape.
Formation Processes of Maritime Archaeological Landscapes

hal-01448703
https://hal.archives-ouvertes.fr/hal-01448703

Éditeur(s) : HAL CCSD
Résumé : International audience
Background: Everyone is subject to environmental exposures from various sources, with negative health impacts (air, water and soil contamination, noise...) or with positive effects (e.g. green space). Studies considering such complex environmental settings in a global manner are rare.Aims: We propose to use data mining techniques to create a composite exposure index with a data-driven approach, in view to assess the environmental burden experienced by populations. We illustrate this approach on a large French metropolitan area.Methods: The study was carried out in the Great Lyon area (France, 1,260,348 inhabitants in 2007, 527 km²) at the census block group (BG) scale. Indicators on NO2 annual concentrations, noise levels, proximity to green spaces and to industrial plants, and road traffic were synthetized using Multiple Factor Analysis (MFA), which allows to explore the relations between exposures and BGs without a priori knowledge, and to synthetize indicators of different types. Hierarchical clustering was then used to create BG classes. Results: The four first components of the MFA explained respectively 23, 14, 13 and 12% of the total variance. Clustering in 3 classes group: 1) BGs far from industries, greener and with less noise and air pollution than the average; 2) BGs close to industries with less green spaces and air pollution than the average; and 3)BGs far from industries but with higher levels of noise, air pollution and traffic. Greater numbers of classes were tested in order to assess a variety of clustering.Conclusions: We present a data driven approach using data mining techniques, which seem overlooked for cumulative exposure assessment in complex environmental settings. Although it cannot be applied directly for risk or health effect assessment, the resulting index can help to identify hot spots of cumulative exposure, to prioritize urban policies or to compare the environmental burden across study areas in an epidemiological framework.
Environment and Health – Bridging South, North, East and West. Conference of ISEE, ISES and ISIAQ.
Basel, Switzerland

hal-01432884
https://hal.archives-ouvertes.fr/hal-01432884
https://hal.archives-ouvertes.fr/hal-01432884/document
https://hal.archives-ouvertes.fr/hal-01432884/file/Poster_2013_ISEE_20130711.pdf

Éditeur(s) : ISTPM
Résumé : The 1951 cruise of the "Président-Théodore-Tissier" was conducted from February 13th to June 30th, 1951. During these four and a half months, the vessel, which departed from Brest, stopped successively in Madeira, the French Caribbean, the Bermudas, Woods Hole, Halifax, on the banks of Newfoundland, the Azores Islands, Saint-Jean-de-Luz, and then sailed back to Brest after 13,000 miles in the Northern Atlantic Ocean. The North-Western Atlantic and the Caribbean Pycnogonida have been the focus in 1948 of a very comprehensive and documented review by J. W. Hedgpeth followed by a catalogue of the stations of the different expeditions which worked in the Northern Atlantic Ocean and the studied species. Moreover, the work of Marcus (1940) on the South-American Pycnogonida is an excellent basis for the study of the tropical Atlantic Pycnogonida. Recently, J.-H. Stock (1954 a) published a preliminary study on Pycnogonida collected at small depths in the Caribbean. During the 1951 cruise of the "Président-Théodore-Tissier", 15 species of Pycnogonida were collected at 16 stations which can be classified, from a biogeographic point of view, in five groups of unequal importance: the floating sargassum (8 stations), the Little Caribbean (5 stations), the Bermudas (1 station), the surroundings of Wood Hole (1 station), the banks of Newfoundland (1 station).
La croisière 1951 du « Président-Théodore-Tissier» a duré du 13 février au 30 juin 1951. Pendant ces quatre mois et demi, le navire, parti de Brest, s'est rendu successivement à Madère, aux Antilles française, aux Bermudes, à Woods Hole, à Halifax, sur les Bancs de Terre-Neuve, aux Açores, à Saint-Jean-de-Luz, et est rentré à Brest après avoir parcouru plus de 13.000 milles dan l'Atlantique Nord. Les Pycnogonides de l'Atlantique Nord-Ouest et des Antilles ont fait l'objet en 1948 d'une révision très complète et documentée de J. W. Hedgpeth suivie d'un catalogue des stations des différentes expéditions ayant travaillé dans l'Atlantique Nord et des espèces récoltées. Par ailleurs, le travail de Marcus (1940) sur les Pycnogonides sud-américains constitue une excellente base pour l'étude des Pycnogonides de l'Atlantique tropical. Enfin, tout récemment J.-H. Stock (1954 a) a publié une étude préliminaire des Pycnogonides récoltés à faible profondeur dans les Antilles. Au cour de la campagne 1951 du «Président-Théodore-Tissier », 15 espèces de Pycnogonides ont été recueillies en 16 stations qui peuvent, au point de vue biogéographie, être classés en cinq groupes d'importance très inégale: les sargasses flottantes (8 stations), les petites Antilles (5 stations), les Bermudes (1 station), les environs de Wood Hole (1 station), les Bans de Terre-Neuve (1 station). ATTENTION : Ce texte a été extrait du document par un processus automatique, non contrôlé, de reconnaissance optique de caractères (OCR). Il est donc susceptible de comporter des erreurs. En cas de doute, consultez le fichier PDF.
Revue des Travaux de l'Institut des Pêches Maritimes (0035-2276) (ISTPM), 1955-12 , Vol. 19 , N. 4 , P. 581-609

Droits : Ifremer
http://archimer.ifremer.fr/doc/1955/publication-6612.pdf
http://archimer.ifremer.fr/doc/00000/6612/

Éditeur(s) : HAL CCSD Coastal Education and Research Foundation
Résumé : Nearshore bars are generally present on sandy coasts and play a significant role in wave breaking and sediment exchange between beach and shoreface. The study area is located on the Languedoc-Roussillon coast in the Gulf of Lions (southern part of the French Mediterranean coast). This microtidal environment is classified as a wave-dominated coast. The sand coast displays different bar systems (single or multiple; straight or crescentic). The alongshore variability of bar morphology in the nearshore zone was investigated in August 2009 during one week, using a topo-bathymetric LIDAR data set (300 km(2)). LIDAR makes it possible to cover a large area in a very short time with a high resolution. The topo-bathymetric LIDAR offers the added benefit of morphological information about the beach-sea transition in very shallow water (below I in), data often difficult if not impossible to obtain with traditional techniques. The purpose of this paper is 1) to depict the distribution of bars and their characteristics along the 180 km coast of the Gulf of Lions; 2) to update the classifications of sand bars typologies in Languedoc-Roussillon; 3) to pay particular attention to the description of the intricate inner system. Globally, cross-shore distribution of subtidal morphologies is characterized by both an outer and an inner system. The outer system is crescent-shaped in the south and straight in the northern part with a distinctive regional delimitation. The inner system comprises an inner bar and, near the coast, a complex fluctuating bar called Low Bar Beach (LBB). Several intermediate states were identified and added to the new classification proposed in this paper. These results clearly emphasize the importance of LIDAR technology for a better understanding of bar behaviour and single and/or multi-bar beach organisation.
ISSN: 0749-0208

hal-00783187
https://hal.archives-ouvertes.fr/hal-00783187

Éditeur(s) : HAL CCSD
Résumé : International audience
We present the principle and the main steps of a new method for the visuo-spatial analysis of geometrical sketches recorded online. Visuo-spatial analysis is a necessary step for multi-level analysis. Multi-level analysis simultaneously allows classification, comparison or clustering of the constituent parts of a pattern according to their visuo-spatial properties, their procedural strategies, their structural or temporal parameters, or any combination of two or more of those parameters. The first results provided by this method concern the comparison of sketches to some perfect patterns of simple geometrical figures and the measure of dissimilarity between real sketches. The mean rates of good decision higher than 95% obtained are promising in both cases.
Proceedings of the 2010 International Conference on Image Processing, Computer Vision, & Pattern Recognition

Droits : info:eu-repo/semantics/OpenAccess
hal-00514929
https://hal.archives-ouvertes.fr/hal-00514929
https://hal.archives-ouvertes.fr/hal-00514929/document
https://hal.archives-ouvertes.fr/hal-00514929/file/IPCV2010_-_RRP.pdf
ARXIV : 1305.1520

Éditeur(s) : HAL CCSD Lippincott, Williams & Wilkins
Résumé : International audience
Objectives: Lung cancer risk associated with occupational cleaning activities has been investigated in the population-based case-control study ICARE. Methods: Occupational history was collected by standardized interviews. Jobs were first defined according to the International Standard Classification of Occupations (ISCO) codes and then categorized according to activity sectors. Adjusted odds ratios (ORs) were estimated by unconditional logistic regression, separately for women (619 cases and 760 controls) and men (2265 and 2780). Results: Thirty percent of women and 2.3% of men controls ever held a cleaner or care job. Women who worked as housemaids longer than 7 years showed an OR of 1.76 [95% confidence interval (95% CI) 1.09 to 2.87] with respect to controls. Women employed in domestic service sector for a long time had an OR of 2.06 (95% CI 1.15 to 3.66). Conclusion: We confirmed and redefined the association of lung cancer with occupational cleaning, which concerns a considerable proportion of women workers.
ISSN: 1076-2752

hal-01359564
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01359564
DOI : 10.1097/JOM.0000000000000722
PUBMED : 27206119

Éditeur(s) : HAL CCSD Springer Verlag (Germany) Springer Verlag
Résumé : International audience
Apoptosis has emerged as a fundamental process important in tissue homeostasis, immune response, and during development. CD95 (also known as Fas), a member of the tumor necrosis factor receptor (TNF-R) superfamily, has been initially cloned as a death receptor. Its cognate ligand, CD95L, is mainly found at the plasma membrane of activated T-lymphocytes and natural killer cells where it contributes to the elimination of transformed and infected cells. According to its implication in the immune homeostasis and immune surveillance, and since several malignant cells of various histological origins exhibit loss-of-function mutations, which cause resistance towards the CD95-mediated apoptotic signal, CD95 has been classified as a tumor suppressor gene. Nevertheless, this assumption has been recently challenged, as in certain pathophysiological contexts, CD95 engagement transmits non-apoptotic signals that promote inflammation, carcinogenesis or liver/peripheral nerve regeneration. The focus of this review is to discuss these apparent contradictions of the known function(s) of CD95.
ISSN: 1420-682X

hal-00682466
https://hal.archives-ouvertes.fr/hal-00682466
DOI : 10.1007/s00018-011-0866-4
PUBMED : 22042271

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
ISSN: 0378-1127

hal-01087219
https://hal-agroparistech.archives-ouvertes.fr/hal-01087219
DOI : 10.1016/j.foreco.2008.09.010

Éditeur(s) : HAL CCSD
Résumé : Macrophages (MΦ), well-known to play a key role in immune response, also respond to environmental toxic chemicals such as diesel exhaust particles (DEP), an air pollutant recently classified as carcinogenic to humans. MΦ are heterogeneous and plastic cells which activate according to their microenvironment into either an M1 subtype (so called classically activated or pro-inflammatory) under IFNγ and LPS stimulation or an M2 subtype (so called alternatively activated or anti-inflammatory) under IL-4 and/or IL-13 stimulation. However, potential effects of DEPs on M1/M2 MΦ polarization remain poorly documented. First, we characterized the expression marker of in vitro M-CSF-differentiated MΦ from human monocytes and activated into the M1 or M2 subtypes. Our main results show that M-CSF-generated MΦ considered as anti-inflammatory are actually able to switch to an M1 phenotype after IFNγ/LPS stimulation. Furthermore, the markers identified in this study were used to assess the impact of organic extracts of DEP (DEPe) on MΦ polarization and more generally on their physiology. DEPe alter some M1 and M2 markers expressed by polarized MΦ, without causing the overall inhibition of the M1 and M2 polarization process or the switch to a different phenotype. This phenotype alteration is associated with a decrease in the LPS-dependent inflammatory response in M1 MΦ and the chemotactic capacities in M2 MΦ. DEPe decrease the secretion of some cytokines and chemokines such as IL-6, IL-12p40 and CCL18 via AhR and/or Nrf2 activation. At the same time, we show that M1 and M2 MΦ in response to DEPe are able to secrete a sufficient level of a pro-fibrotic growth factor, the platelet derived growth factor B (PDGF-B) via AhR activation, leading to stimulation of lung fibroblast proliferation. Finally, these works show that DEPe have immunotoxic properties with regards to the physiology of human in vitro polarized MΦ. This immunotoxicity may then contribute to the deleterious effects of these urban environmental contaminants on human health.
Les macrophages (MΦ), des cellules clefs de la réponse immunitaire peuvent répondre à des contaminants environnementaux comme les particules diesel (DEP), des polluants atmosphériques récemment classés cancérigènes pour l'Homme. Les MΦ sont des cellules hétérogènes et plastiques qui s'activent en fonction de leur microenvironnement soit en MΦ M1 (dits classiquement activés ou pro-inflammatoires) sous l'effet de l'INFγ et du LPS soit en MΦ M2 (dits alternativement activés ou réparateurs) sous l'effet de l'IL-4 et/ou de l'IL-13. Les effets des DEP sur la polarisation M1/M2 des MΦ restent peu documentés. Nous avons dans un premier temps caractérisé l'expression des marqueurs des MΦ différenciés in vitro en présence de M-CSF à partir de monocytes humains et polarisés en sous-type M1 ou M2. Nos principaux résultats montrent que les MΦ différenciés au M-CSF considérés comme des MΦ anti-inflammatoires, sont en réalité capables de s'activer vers un phénotype M1 après une stimulation au LPS/IFNγ. De plus, les marqueurs mis en évidence au cours de ce travail ont permis d'évaluer l'impact d'extraits organiques de DEP (DEPe) sur la polarisation des MΦ et plus généralement sur leur physiologie. Les DEPe altèrent l'expression de certains marqueurs M1 et M2 des MΦ, sans toutefois provoquer d'inhibition globale des processus de polarisation M1 et M2 ou de transition d'un phénotype vers un autre. Cette altération du phénotype est associée à une diminution de la réponse inflammatoire LPS-dépendante dans les MΦ M1 et des capacités chimiotactiques des MΦ M2. Les DEPe diminuent la sécrétion de certaines cytokines et chimiokines comme l'IL-6, l'IL-12p40 et le CCL18 via l'activation d'AhR et/ou de Nrf2. Parallèlement, nous montrons que les MΦ M1 et M2 exposés aux DEPe sécrètent le platelet deried growth factor B (PDGF-B), un facteur de croissance profibrosant, via l'activation d'AhR en quantité suffisante pour stimuler la prolifération de fibroblastes pulmonaires. Au total, ces travaux démontrent que les DEP possèdent des propriétés immunotoxiques vis-à-vis de la physiologie des macrophages humains polarisés in vitro. Cette immunotoxicité pourrait participer aux effets délétères de ces contaminants environnementaux urbains sur la santé humaine.
https://tel.archives-ouvertes.fr/tel-01188679

NNT : 2015REN1S011
tel-01188679
https://tel.archives-ouvertes.fr/tel-01188679
https://tel.archives-ouvertes.fr/tel-01188679/document
https://tel.archives-ouvertes.fr/tel-01188679/file/JAGUIN_Marie.pdf

Éditeur(s) : HAL CCSD
Résumé : National audience
We propose a method to solve the problem of clustering individuals described by mixed variables structured in blocks. It is a hierarchical method with two levels similar to Hierarchical Principal Component Analysis presented by Wold, based on the mixed topology maps (MTM). The first step consists in establishing, for each block of mixed variables, a clustering representing a synthesis of local individuals at the block level. The second step is to re-apply MTM on the weighted results of the first level. We obtain a global clustering of individuals, consensus among the partitions from level 1. The proposed method is illustrated on data from the national survey in the French housing stock carried out in 2003-2005 by the Observatory for Indoor Air Quality (OQAI).
Fouille de Données Complexes, complexité liée aux données multiples et massives (FDC)
bordeaux, France

hal-00748841
https://hal.archives-ouvertes.fr/hal-00748841
https://hal.archives-ouvertes.fr/hal-00748841/document

Éditeur(s) : HAL CCSD The Royal Society of Chemistry
Résumé : International audience
This review is devoted to the description of synthetic strategies for glycodendrimers synthesis. Dendrimers can be classified into three categories: carbohydrate-coated, carbohydrate-centered and carbohydrate-based dendrimer. In this paper we will focus on the third one, in which the core unit is originated from a monosaccharide. Compare to classical Pamam, Boltorn cores, carbohydrate units add much more three dimension information, coded in the chirality in almost each carbon. Various coupling chemistry have been developed and are presented here: glycosylation, amide bound formation, and click chemistry (thiol-ene reaction, epoxide - thiol reaction).
Carbohydrate Chemistry: Volume 40

ISBN : 978-1-84973-965-8
hal-01362709
https://hal.archives-ouvertes.fr/hal-01362709
DOI : 10.1039/9781849739986-00257

Éditeur(s) : HAL CCSD
Résumé : International audience
We propose in this article a color image segmentation technique based on an optimization of the Mean Shift method. It consists in classifying clusters of data points of a digital image, it does not require any preliminary designation of the number of classes and of their centers. The Mean Shift method applied to a digital color image creates a new image made up of aggregates of points belonging to a finished number of color classes. The complexity of this method based on a global approach of the image is in O(NxN), N being the number of pixels of the image. Our idea consists in applying a change of scale to the image to be segmented, to reduce the quantity of information and, in using a median filter to decrease the number of colors to minimize the complexity of the latter. The comparative study which we present shows that the optimization which we proposed gives better, reliable results than the classic use of the Mean Shift method.
Complex, Intelligent and Software Intensive Systems, International Conference
Cracovie, Poland

hal-00508427
https://hal.archives-ouvertes.fr/hal-00508427
DOI : 10.1109/CISIS.2010.62